DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5618 and Gadl1

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001382689.1	Gene:	Gadl1 / 73748	MGIID:	1920998	Length:	522	Species:	Mus musculus

Alignment Length:	513	Identity:	241/513 - (46%)
Similarity:	340/513 - (66%)	Gaps:	36/513 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VDGAETVDQIRDGLMDDWK------------ILENVFHLLRKEDTFCVDPQKWDKQKIVPFLQPD 57
            |||.     :.:|...|.|            |:|.|  :|:..|.         .:|:..:..|:
Mouse    31 VDGV-----VLNGPQTDVKAGEKFVEEACRLIMEEV--VLKATDV---------NEKVCEWQPPE 79

  Fly    58 KLKELINLKVRETENCSLAEIEELCQQVIHYSVKTSHGRFHNQLFGQLDPFGLAGALVTEAMNGS 122
            :|::|::|::|:|.. |..::.:|||.|||:||||:|.||.|||:..||.:.||..::|||:|.|
Mouse    80 QLRQLLDLEMRDTGE-SQDKLLKLCQDVIHFSVKTNHPRFFNQLYAGLDYYSLAARIITEALNPS 143

  Fly   123 TYTYEVAPVFSLIETEVIATICKLAGYKEGDGIFAPGGSTSNMYGMVLARYKIAPEVKTSGMFGM 187
            .|||||:|||.|:|..|:..:.:..|:|||||||.||||.|||..|.||||:..|::|..|:.|:
Mouse   144 IYTYEVSPVFLLVEEAVLKKMIECVGWKEGDGIFNPGGSVSNMCAMNLARYRHCPDIKEKGLSGL 208

  Fly   188 RPLVLFTSDESHYSFVKAANWLGLGSYNCVSVRTNERGQMLLDDLEAKIAEAKARGGEPFFVNCT 252
            ..|:||||.|.|||..|||::||:|:.|...|.|:.||:|:.:|||.:|.:|:..|..||.|..|
Mouse   209 PRLILFTSAECHYSMKKAASFLGIGTQNVYFVETDGRGKMIPEDLEKQIWQARQEGAVPFLVCAT 273

  Fly   253 AGTTVLGAFDDINGAADVTERHGLWLHVDACLGGAALLSAKNRSLIAGLERANSFSWNPHKTIGA 317
            :|||||||||.::..|:|.|||||||||||..||:||:|.|:|.|:.|:.||:|.:|||||.:.|
Mouse   274 SGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMA 338

  Fly   318 PLQCSLFLTRESGRLLERCNSTEAHYLFQQDKFYDVSYDTGNKSVQCGRKIDAFKFWLMLKARGY 382
            .:|||..|.::...||::|.|.:|.||||||||||||||||:||:||.|:.||||||:..||.|.
Mouse   339 GIQCSALLVKDKSDLLKKCYSAKATYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGT 403

  Fly   383 GKYGLMVDHAIHIARLLEGKLRQRGDRFRLVIPEHEYSNVCFWFIPKAMRVSSEEETPEWWSRLY 447
            ......|:.|..::|.|..::::| :.|:|:: |.||:|||||:||.::|  ..||.||:|.:|.
Mouse   404 SGLEERVNRAFALSRYLVDEIKKR-EGFKLLM-EPEYTNVCFWYIPPSLR--EMEEGPEFWRKLS 464

  Fly   448 TVAPKIKEQMAHSGTLMIGYSPLKAKNLGNFFRMVFTCFPILKSKELDFILDEIERLG 505
            .|||.|||:|...|:||:||.|.:.|  .||||.| ...|.:..:::||:||||:.||
Mouse   465 LVAPAIKEKMMKKGSLMLGYQPHRGK--VNFFRQV-VISPQVSREDMDFLLDEIDSLG 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	208/406 (51%)
Gadl1	NP_001382689.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3597
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	O	PTHR45677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.780