Protein Alignment CG5618 and HDC

DIOPT Version :10

• Sequence 1: NP_649211.1
• Gene: CG5618 / 40241
• FlyBaseID: FBgn0036975
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Alignment Length: 420
• Identity: 99/420 - (23%)
• Similarity: 172/420 - (40%)
• Gaps: 80/420 - (19%)

  Fly    47 KQKIVPFLQPDKLKELINLKVRE---TENCSLAEIEELCQQ-VIHYSVKTSHGRFHNQLFGQLDP 107
            ::::.|.:||..|:..:.....|   :.:....:||.:... |:|:.....|.     .:..|..
Human    27 ERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHA-----YYPALTS 86

  Fly   108 F-GLAGALVTEAMNGSTYTYEVAPVFSLIETEVIATICKLAGYKE----------GDGIFAPGGS 161
            : .|.|.::.:|:|...:|:..:|..:.:|..|:..:.|:.|..|          |.|:.....|
Human    87 WPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVS 151

  Fly   162 TSNMYGMVLARYKIAPEVKTSGMFGMRP----------LVLFTSDESHYSFVKAANWLGLGSYNC 216
            .|.:..::.||.....|:|||     .|          ||.:.||::| |.|:.|..:.|.....
Human   152 ESTLIALLAARKNKILEMKTS-----EPDADESCLNARLVAYASDQAH-SSVEKAGLISLVKMKF 210

  Fly   217 VSVRTN--ERGQMLLDDLEAKIAEAKARGGEPFFVNCTAGTTVLGAFDDINGAADVTERH----- 274
            :.|..|  .||:.    |:..|.|.|.||..|.||..|.|||.:.|||.::....:::.|
Human   211 LPVDDNFSLRGEA----LQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPISKAHHPCSP 271

  Fly   275 ------------------------------GLWLHVDACLGGAALLSAKNRSLIAGLERANSFSW 309
                                          |||||:||...|.|.|..:.|..:.|:|.|:||::
Human   272 PLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTF 336

  Fly   310 NPHKTIGAPLQCSLFLTRESGRLLERCNSTEAHYLFQQDKFYDVSYDTGNKSVQCGRKIDAFKFW 374
            ||.|.:.....|:.|..::..: |::..|....||...:.  .|:.|..:..:...|:..:.|.|
Human   337 NPSKWMMVHFDCTGFWVKDKYK-LQQTFSVNPIYLRHANS--GVATDFMHWQIPLSRRFRSVKLW 398

  Fly   375 LMLKARGYGKYGLMVDHAIHIARLLEGKLR 404
            .::::.|.......|.|...:|:..|..:|
Human   399 FVIRSFGVKNLQAHVRHGTEMAKYFESLVR 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	GadA	56..507	CDD:439846	97/411 (24%)
HDC	XP_016877583.1	Pyridoxal_deC	36..449	CDD:395219	97/411 (24%)