DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5618 and GAD2

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000809.1	Gene:	GAD2 / 2572	HGNCID:	4093	Length:	585	Species:	Homo sapiens

Alignment Length:	499	Identity:	214/499 - (42%)
Similarity:	317/499 - (63%)	Gaps:	21/499 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DGLMDDWKILENVFHLLRKEDTFCVDPQKWDKQ-KIVPFLQPDKLKELINLKVRETENCSLAEIE 79
            ||.......|::|.::|.:   :.|  :.:|:. |::.|..|::|.:..|.::.:... :|.||.
Human   102 DGERPTLAFLQDVMNILLQ---YVV--KSFDRSTKVIDFHYPNELLQEYNWELADQPQ-NLEEIL 160

  Fly    80 ELCQQVIHYSVKTSHGRFHNQLFGQLDPFGLAGALVTEAMNGSTYTYEVAPVFSLIETEVIATIC 144
            ..||..:.|::||.|.|:.|||...||..|||...:|...|.:.:|||:||||.|:|...:..:.
Human   161 MHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMR 225

  Fly   145 KLAGYK--EGDGIFAPGGSTSNMYGMVLARYKIAPEVKTSGMFGMRPLVLFTSDESHYSFVKAAN 207
            ::.|:.  .|||||:|||:.||||.|::||:|:.||||..||..:..|:.|||:.||:|..|.|.
Human   226 EIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAA 290

  Fly   208 WLGLGSYNCVSVRTNERGQMLLDDLEAKIAEAKARGGEPFFVNCTAGTTVLGAFDDINGAADVTE 272
            .||:|:.:.:.::.:|||:|:..|||.:|.|||.:|..||.|:.||||||.||||.:...||:.:
Human   291 ALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICK 355

  Fly   273 RHGLWLHVDACLGGAALLSAKNRSLIAGLERANSFSWNPHKTIGAPLQCSLFLTRESGRLLERCN 337
            ::.:|:||||..||..|:|.|::..::|:|||||.:|||||.:|.|||||..|.||.| |::.||
Human   356 KYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEG-LMQNCN 419

  Fly   338 STEAHYLFQQDKFYDVSYDTGNKSVQCGRKIDAFKFWLMLKARGYGKYGLMVDHAIHIARLLEGK 402
            ...|.|||||||.||:|||||:|::||||.:|.||.|||.:|:|...:...||..:.:|..|...
Human   420 QMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNI 484

  Fly   403 LRQRGDRFRLVI---PEHEYSNVCFWFIPKAMRVSSEEETPEWWSRLYTVAPKIKEQMAHSGTLM 464
            ::.| :.:.:|.   |:|  :|||||:||.::|...:.|  |..|||..|||.||.:|...||.|
Human   485 IKNR-EGYEMVFDGKPQH--TNVCFWYIPPSLRTLEDNE--ERMSRLSKVAPVIKARMMEYGTTM 544

  Fly   465 IGYSPLKAKNLGNFFRMVFTCFPILKSKELDFILDEIERLGEKI 508
            :.|.||..|  .||||||.: .|....:::||:::||||||:.:
Human   545 VSYQPLGDK--VNFFRMVIS-NPAATHQDIDFLIEEIERLGQDL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	189/411 (46%)
GAD2	NP_000809.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Pyridoxal_deC	138..509	CDD:278699	169/375 (45%)
		Substrate binding	181..183		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730