Protein Alignment polo and CDC5

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_013714.1
• Gene: CDC5 / 855013
• SGDID: S000004603
• Length: 705
• Species: Saccharomyces cerevisiae
• Alignment Length: 633
• Identity: 194/633 - (30%)
• Similarity: 318/633 - (50%)
• Gaps: 101/633 - (15%)

  Fly    23 KTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVK 87
            |.|.|..|.|:||||:|::|.| ::.::||.|.|:|..:.....::|...||.||:|::|||||:
Yeast    80 KDYHRGHFLGEGGFARCFQIKD-DSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQ 143

  Fly    88 FHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLG 152
            |.:.|||..|:||:||:|...|:|||.||||.:||.|.|::..||...:||:|..|:||||||||
Yeast   144 FIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLG 208

  Fly   153 NLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKK--GHSFEVDIWSIGCVMYT 215
            |:|.:...::||||||||..:..|.|||.|:||||||||||:|..|  ||||||||||:|.::|.
Yeast   209 NIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYA 273

  Fly   216 LLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAAD----MVIAMLQPNPESRPAIGQLLNFEF 276
            ||:|:|||:.:.:...|.:||..::..|.  .||.:|    ::..:|..:|..||::.:::::.:
Yeast   274 LLIGKPPFQARDVNTIYERIKCRDFSFPR--DKPISDEGKILIRDILSLDPIERPSLTEIMDYVW 336

  Fly   277 LKGSKVPMFLPSSCLTMAPRI------------------------------------------GS 299
            .:|: .|..:||:.::.||..                                          .|
Yeast   337 FRGT-FPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQKRDYISSIKSS 400

  Fly   300 NDTIEDSMHRKPLMEMNGIRPDDT--------------RLESTFLKANLHDA---------ITAS 341
            .|.:|:....:|.:. :.:.|..|              ||.....:|.:..|         |..|
Yeast   401 IDKLEEYHQNRPFLP-HSLSPGGTKQKYKEVVDIEAQRRLNDLAREARIRRAQQAVLRKELIATS 464

  Fly   342 AQVCRHSEDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGY 406
            ..|.:.....|......:..|..::..:.:...|.|..........|:. ::||||||:|:||.|
Yeast   465 TNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLPKSRLPKIKHPMI-VTKWVDYSNKHGFSY 528

  Fly   407 QLCDEGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTT----TDYCKSLDKKMKLLSYFKRYM 467
            ||..|.|||:||:.|.::.|.:.....:|..|.:|.::.:    ::..:.|.:.::::.:|.:||
Yeast   529 QLSTEDIGVLFNNGTTVLRLADAEEFWYISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYM 593

  Fly   468 IEHLVKAGANNVN------IESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLNFSDHMKLILCPR 526
                 ||..:.|:      ...|.:    .|..:.|....|:..|::|:.|.||.||.|:.:...
Yeast   594 -----KANLSRVSTFGREEYHKDDV----FLRRYTRYKPFVMFELSDGTFQFNFKDHHKMAISDG 649

  Fly   527 MSAITYMDQEKNFRTYRFSTIVENG-----VSKDLYQKIRYAQEKLRK 569
            ...:||:.......||....:::.|     ...:..:|:...:|.|::
Yeast   650 GKLVTYISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQ 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	120/259 (46%)
		POLO_box_1	388..475	CDD:240561	29/90 (32%)
		POLO_box_2	490..570	CDD:240560	19/85 (22%)
CDC5	NP_013714.1	STKc_PLK	80..337	CDD:271001	120/259 (46%)
		POLO_box_1	510..601	CDD:240561	30/96 (31%)
		POLO_box_2	613..698	CDD:240560	19/89 (21%)