DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gogo and Thsd1

DIOPT Version :9

Sequence 1:	NP_649200.2	Gene:	gogo / 40225	FlyBaseID:	FBgn0052227	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_062522.1	Gene:	Thsd1 / 56229	MGIID:	1929096	Length:	851	Species:	Mus musculus

Alignment Length:	1038	Identity:	210/1038 - (20%)
Similarity:	329/1038 - (31%)	Gaps:	327/1038 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SSIMLLLLSGTSHVLAVRKGRLMSPSTFTALSGDLHVQIQFNGNEMSSQAEEEHTIGGGPSNEEP 100
            |:::|::|  ..:||...:..|:......||| |..|.:.|:                      .
Mouse     9 SNLLLVVL--CDYVLGEAEYLLLQEPVHVALS-DRTVSVGFH----------------------Y 48

  Fly   101 LSSSDGLKSRNNTIMSTLVISKIIDEVESPLEKGLTPGPEVTNTSQVVLHRKRKEVVQNIPLFPD 165
            ||..:| ..||.::|..          |:...:.||....:||.:|..|.
Mouse    49 LSDVNG-TLRNVSVMLW----------EANTNRTLTTKYLLTNQAQGTLQ--------------- 87

  Fly   166 PRFNVTQVTVPCQTFLIGGRYEMQVVSNLKSVNRSEVTT--TLVPAQDERLHQTLDVRWP----- 223
                     ..|..|...|.|...::        .|||.  |.||..::...  |.|.||
Mouse    88 ---------FECFYFKEAGDYWFVMI--------PEVTDNGTQVPLWEKSAF--LKVEWPVFHID 133

  Fly   224 ---SAEMIVSPVRLKTYPKHPVEVTLRFPEVNCNQSGSLALPEFWLELIYCGKDRSCNRNITPTS 285
               :|:......::..:...|:   ..||         :..|:..:::|:..:......::....
Mouse   134 LNRTAKAAEGTFQVGVFTTQPL---CLFP---------VDKPDMLVDVIFTDRLPEARASLGQPL 186

  Fly   286 VLFAEQIRGFPKNKSLHLGCELFGLAGNYAVQLRPMIPAQNVPTTRRLLSVDWSDEFVFNVYARS 350
            .:.|.:.....:.:.:..||...|:.....|.||.:.....:.:|.   .:|.:.:|.:.:....
Mouse   187 EIRASKRTKLTQGQWVEFGCAPVGVEAYVTVMLRLLGQDSVIASTG---PIDLAQKFGYKLMMAP 248

  Fly   351 IFPCDPHTGIGVLYEYPGCILEQGDRVRLYARLRADVASLKPPTSLHYVSEQRVVKSQHSLYFAC 415
            ...|:....:.||  .|.|:..|| .:.:|..     |..:|......|:|.|:...:....|.|
Mouse   249 EVTCESVLEVMVL--PPPCVFVQG-VLAVYKE-----APKRPEERTFQVAENRLPLGERRTVFNC 305

  Fly   416 EHFSEKYVEYCFVY--VSQAISGAVADVRMDCVPTLPVSDSDTGGWGPWSEWTPCSTNCLGGTRN 478
            ..|.....:|||.:  |.:....|     .:|:  |...:.:|  ||||..|:||||.|....|.
Mouse   306 TLFDVGKNKYCFNFGIVKKGHFSA-----KECM--LIQRNIET--WGPWQPWSPCSTTCGDAVRE 361

  Fly   479 RYRFC-DSPPPRYGAKFCEGPSVETQKCGKSIADTWDCIYETSGTVITKENSTEVSQEIGPGCRC 542
            |.|.| .|.|.|   ..|.|.|.||..|...     :|      .|......:.||.:
Mouse   362 RRRLCVTSFPSR---PSCSGMSSETSPCSLE-----EC------AVFRPPGPSPVSPQ------- 405

  Fly   543 GCIVHLGSSKPKRIIAGATQSCPGRSFWLIQVDGEESISLALSFLRLP-CATQYIKVRDGPSLSS 606
                  ...|...::     :..|.|..|..:.....|:|...|.|.| |:|   .||.. |:.|
Mouse   406 ------DPVKSNNVV-----TVTGISLCLFIIFATVLITLWRRFGRAPKCST---PVRHN-SIHS 455

  Fly   607 TLLVELNGGGLILKGAGVPVVVDSTGGQLLVEFS--------AGDGPAGNATQEASPACTG---- 659
                              |....::..:.:.|.|        |||||.|      ||..||
Mouse   456 ------------------PGFRKNSDEENICELSEPRGSFSDAGDGPRG------SPGDTGIPLT 496

  Fly   660 -----------------GFMANVQQ--------RLATRS----SNSSITLVAATRLSGKTRSVVH 695
                             .|.:|.|:        |||.:.    ....:|         :|..|.|
Mouse   497 YRCSASAPPEDEASGSESFQSNAQKIIPPLFSYRLAQQQLKEMKKKGLT---------ETTKVYH 552

  Fly   696 KSMSRLRFTLVHLSAM----------IFASIIIIISSLL---GAQYVVRYRKYHLAVARRQDEGS 747
            .|.|.|..|:|..:|.          ..||...|.|..|   ||                 ..|.
Mouse   553 VSQSPLTDTVVDATASPPLDLECPEEAAASKFRIKSPFLDQPGA-----------------GTGE 600

  Fly   748 RLHTPRASLSSLQGPPSRAMSTTTLLSEVIYMVKMR---------PKHHLRHSILRESVDAENLT 803
            |   |.:.|..:..||..|:|.:..|   |...::|         .:.|.|.|:.|.:.......
Mouse   601 R---PPSRLDGIVPPPGCAVSPSQTL---IRKSQIRSTGGRDGSSERCHSRSSLFRRTASFHETK 659

  Fly   804 KETEFKESDSQGMLAKCAEIKELGS-----------------SASMVTLRNER-------SSPAR 844
            :...|:|.....:..:  ::....|                 |..::..|.|.       |||..
Mouse   660 QSRPFRERSLSALTPR--QVPAYSSRMRTWDQMEDRCRPPSRSTHLLPERPEHFQGAGRTSSPLG 722

  Fly   845 SLDTGSIIG------SPSSAEAELAAVHSRSE----------SKDSPSDEPIEPPSCKDSARDSE 893
            .|.....:|      .|...:|.|.|...:.|          |..|.|.:...|...|||.:...
Mouse   723 PLSKSYTVGHPRRKPDPGDRQAGLVAGAEKMEPHRAHRGPSPSHRSASRKQSSPIFLKDSYQKVS 787

  Fly   894 SIISSGM-SSLCNSPPMN---------SKRLSKYSDRYDAVTLKLLSSRLDESLQDASSLLSV 946
            .:..|.. ...|.|.|::         |.||::...|...:.....|:..||:    :|.|||
Mouse   788 QLSPSHFRKDKCQSFPIHPEFAFYDNTSFRLTEAEQRMLDLPGYFGSNEEDET----TSTLSV 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gogo	NP_649200.2	TSP1	459..505	CDD:214559	22/46 (48%)
		CUB	<570..640	CDD:294042	14/70 (20%)
		AKAP2_C	1049..>1146	CDD:291950
Thsd1	NP_062522.1	PTZ00441	<289..>406	CDD:240420	41/152 (27%)
		TSP1	342..391	CDD:214559	23/56 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..516		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..646		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..777		17/94 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100