DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grasp65 and SPAC1D4.02c

DIOPT Version :9

Sequence 1:	NP_649160.1	Gene:	Grasp65 / 40177	FlyBaseID:	FBgn0036919	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_593015.1	Gene:	SPAC1D4.02c / 2542452	PomBaseID:	SPAC1D4.02c	Length:	345	Species:	Schizosaccharomyces pombe

Alignment Length:	365	Identity:	106/365 - (29%)
Similarity:	171/365 - (46%)	Gaps:	63/365 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IHVPGGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDKPVRLTV 71
            ||.....:.|:.||||:::|....|.:|:::|||.|:.|..|:.|..|...|||.: ...|.|.|
pombe    19 IHRESDESCGFRVLKVENDSKAYNARIESYYDFITAVNGILLNGDPSMFMALLRDS-SPEVTLEV 82

  Fly    72 YSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLRAYSDYV 136
            :|.|.|..|::.:..:::    ..:|:.:::.|...|.:::||||.|..:||...|.|..|.||:
pombe    83 FSLKGQITRKVNIKINSD----EKIGMVLQWASIAPAVDAIWHILNVIDDSPVARASLVPYEDYI 143

  Fly   137 IGA-DAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIGFGYLH 200
            :|. :.:......|..|||:|..:||::|:||...|:.|:|||.||..|||.||:|||:|.|.||
pombe   144 VGTPEGMMTGEKALSDLIESHLNRPLRLYIYNHYRDSTRQVTIVPNRHWGGNGAIGCGVGHGVLH 208

  Fly   201 RIPVQAEPVTSSSAAVPAAAAAESTAPLLTAGGAAPAGAQVAQVVS--PTLPYIPPLANTFGSTN 263
            |:|.   |:   |...|.......:.|:|  ||.....:|.::..:  || |..|.:|:....::
pombe   209 RLPA---PL---SGPPPQPGDIVFSNPML--GGPDHKVSQPSETENFLPT-PEPPKIASANAGSS 264

  Fly   264 AEVRPPTIEPPAQ--------SLFKTYFNPDE--------ATDALTAALESQATIAEPVSVPAPP 312
            .|:..|..:...:        |..::|.:.:|        .|...::..:||.|
pombe   265 NEISIPHYQRHKKSHKGAIQDSSIQSYLDEEEKLSRELDHKTKDASSTNDSQTT----------- 318

  Fly   313 AVADVSVAQPQVQVPAPAQPLPPPANIFIPGVFDPSTQQN 352
                               |||||..:.:....|.|..||
pombe   319 -------------------PLPPPPPVAVNSTNDESAPQN 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grasp65	NP_649160.1	PDZ	<14..100	CDD:294084	27/85 (32%)
Grasp65	NP_649160.1	GRASP55_65	69..205	CDD:282364	53/136 (39%)
SPAC1D4.02c	NP_593015.1	GRH1	1..345	CDD:227558	106/365 (29%)
		PDZ	<19..82	CDD:294084	23/63 (37%)
		GRASP55_65	80..213	CDD:282364	53/139 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	106	1.000	Domainoid score	I1680
eggNOG	1	0.900	-	-		E1_COG5233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I1358
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002082
OrthoInspector	1	1.000	-	-		oto100456
orthoMCL	1	0.900	-	-		OOG6_102404
Panther	1	1.100	-	-	LDO	PTHR12893
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1703
SonicParanoid	1	1.000	-	-		X1377
TreeFam	1	0.960	-	-
	12	11.850