Protein Alignment Mtr3 and EXOSC4

DIOPT Version :10

• Sequence 1: NP_649157.1
• Gene: Mtr3 / 40173
• FlyBaseID: FBgn0036916
• Length: 326
• Species: Drosophila melanogaster
• Sequence 2: NP_061910.1
• Gene: EXOSC4 / 54512
• HGNCID: 18189
• Length: 245
• Species: Homo sapiens
• Alignment Length: 230
• Identity: 62/230 - (26%)
• Similarity: 99/230 - (43%)
• Gaps: 23/230 - (10%)

  Fly    53 RAGVLTTVRGSAYMEYGNTKVLAIVAPPKELIRASARRM-NMGVLNCYVNFAAFSTGDLDSVPER 116
            |.||.....||||:|.||||.||:|..|.|:..:.||.: :..::||..:.|.||||:....|..
Human    28 RMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRPHG 92

  Fly   117 ERHLSSM---LTKAMEPVVCRTEFLNFQLDIRVLILDDDGCLLSTAINCCGVALVECGISTYDLI 178
            :|....|   |.:..|..:........|:||.|.:|..||...:..:|...:|:::.||...|.:
Human    93 DRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFV 157

  Fly   179 TASTACIYRDHVFLNPSAKVEELLWKHRNSSTDSTTSPSSAQEHGLIITASMDTFEQIAQCQQCG 243
            .|.:|. :.|...|...:.|||           :...|..|       .|.:....|||..:...
Human   158 CACSAG-FVDGTALADLSHVEE-----------AAGGPQLA-------LALLPASGQIALLEMDA 203

  Fly   244 YLSPATYVKLLDYTLAINKSLRELVKGVLTKRVKE 278
            .|......::|:......:.:..|:..|:.:.|:|
Human   204 RLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVRE 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr3	NP_649157.1	RNase_PH	47..274	CDD:446015	60/224 (27%)
EXOSC4	NP_061910.1	RNase_PH_RRP41	11..237	CDD:206775	60/227 (26%)