Protein Alignment Mi-2 and rapA

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_414601.1
• Gene: rapA / 948523
• ECOCYCID: EG11083
• Length: 968
• Species: Escherichia coli
• Alignment Length: 798
• Identity: 169/798 - (21%)
• Similarity: 280/798 - (35%)
• Gaps: 227/798 - (28%)

  Fly   600 EERFYKNGVKPEWLIVQRVI----NHRTARDGSTMYLVKWRE----LPYDKSTWEEEGDDIQGLR 656
            |.|.|.....|    |.||:    :..|:.||..|.:.:.:|    |.|..:..:.|...: .||
E. coli    39 ENRLYARSDSP----VTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGV-ALR 98

  Fly   657 QAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQP 721
            :.   :.|.:.|.        ||...:....::   |..||....|.          .:||..:.
E. coli    99 EV---FLDSKLVF--------SKPQDRLFAGQI---DRMDRFALRYR----------ARKYSSEQ 139

  Fly   722 -----AFLEGTGMQLHPYQIEGINWLRYSWGQ--GIDTILADEMGLGKTIQTVTFLYSLYKEGHC 779
                 :.|.|....|.|:|:.    :.:..|:  ....:||||:||||||:....|:.....|..
E. coli   140 FRMPYSGLRGQRTSLIPHQLN----IAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAA 200

  Fly   780 RGPFLVAVPLST----LVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSR 840
            . ..|:.||.:.    ||...|.|.|                |..:.::|              |
E. coli   201 E-RVLIIVPETLQHQWLVEMLRRFNL----------------RFALFDDE--------------R 234

  Fly   841 LRTTQY-KFNVLLTSYELI-SMDAA--------CLGSIDWAVLVVDEAHRL---KSNQSKFFRIL 892
            ....|: .:|...|...:| |:|.|        .|...:|.:|||||||.|   :...|:.::.:
E. coli   235 YAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAI 299

  Fly   893 NSYT--IAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAF---QGEFADVS----------- 941
            ....  :...||||.||.|..:|..|..|..|..::|:|...|   |..:..|:
E. coli   300 EQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNK 364

  Fly   942 -KEEQVKRLHEMLGPH----MLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALN 1001
             ..:::..|.||:|..    :|:...:|......::.|.:..:    |.:.....:|.:|  ..|
E. coli   365 LSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSML----MDRHGTSRVLFRN--TRN 423

  Fly  1002 SKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLK 1066
            ...|.....|..|.:.|          |:..:.|...:|.:....|....|..::...::.::.:
E. coli   424 GVKGFPKRELHTIKLPL----------PTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFE 478

  Fly  1067 AQN-------------------HR----VLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLR 1108
            ..|                   ||    ::|.::....|.:       ||...||  .||...:.
E. coli   479 GDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQL-------EQVLRER--EGIRAAVF 534

  Fly  1109 QEAI-----DRFNA------PGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSR 1162
            .|.:     ||..|      .|||   .||.:..|..|.|...|..::::|..:||....|...|
E. coli   535 HEGMSIIERDRAAAWFAEEDTGAQ---VLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGR 596

  Fly  1163 AHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGG------KGANFTKQELDDI 1221
            ..|||||:.:.|:           |..:.|....:.......|:..      .|........:|:
E. coli   597 LDRIGQAHDIQIH-----------VPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDL 650

  Fly  1222 LRF--------GTEDLFKE-DDKEEAIHYDDKAVAE-----LLDRTNRGIEEKESWANEYLSSFK 1272
            :.:        |.:||.|. .::.||:    ||..|     ||:..:.|.|             |
E. coli   651 INYLASPDQTEGFDDLIKNCREQHEAL----KAQLEQGRDRLLEIHSNGGE-------------K 698

  Fly  1273 VASYATKEEEEEEETEII 1290
            ..:.|...||::::|.:|
E. coli   699 AQALAESIEEQDDDTNLI 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	14/61 (23%)
		PLN03142	720..>1234	CDD:215601	127/607 (21%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
rapA	NP_414601.1	PRK04914	2..966	CDD:235319	169/798 (21%)