Protein Alignment Mi-2 and FUN30

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_009383.1
• Gene: FUN30 / 851214
• SGDID: S000000017
• Length: 1131
• Species: Saccharomyces cerevisiae
• Alignment Length: 1363
• Identity: 322/1363 - (23%)
• Similarity: 512/1363 - (37%)
• Gaps: 463/1363 - (33%)

  Fly    90 DEEVEYPSTSK-------------------------RGR---KRKEEKQAAKEKESASSGMPSVE 126
            |:.|:.|.||.                         |.|   |..:..:.|...:...||.|.|
Yeast    10 DDVVQVPETSSPTKVASSSPLKPTSPTVPDASVASLRSRFTFKPSDPSEGAHTSKPLPSGSPEV- 73

  Fly   127 DVCSAFSVCNVEIE---YSEEELQSLTTYKAF-MHHVRPIL-----QKEN---PKIAAPKLVMLV 179
                  ::.|:..|   :|:..:|::....:| :...|..|     |::|   .|.|:||.
Yeast    74 ------ALVNLAREFPDFSQTLVQAVFKSNSFNLQSARERLTRLRQQRQNWTWNKNASPKK---- 128

  Fly   180 AAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSR----NEKPD--DIYEEA 238
                   .|:.|.:::....|    :.|:..|:.|:     .:::||:    .:|..  |.|...
Yeast   129 -------SETPPPVKKSLPLA----NTGRLSSIHGN-----INNKSSKITVAKQKTSIFDRYSNV 177

  Fly   239 VEEEE-----------EEEEEEKKP----RRKRSGR------GKKGRRPSGKVPTLKIKLLGKRK 282
            :.:::           :.|...|.|    :::|..|      ||.....:.::.:.:.|||..||
Yeast   178 INQKQYTFELPTNLNIDSEALSKLPVNYNKKRRLVRADQHPIGKSYESSATQLGSAREKLLANRK 242

  Fly   283 -----RDSSDEEQ--------DASGASERDSDLEF---ERMLQKSDDSADEKEAPVSSKADNSAP 331
                 .|:.:||:        ||||....:|..:.   |::||..:||   ....:|..:|.:..
Yeast   243 YGRHANDNDEEEEESMMTDDDDASGDDYTESTPQINLDEQVLQFINDS---DIVDLSDLSDTTMH 304

  Fly   332 AAQDDGSGAPVVRKKA--KTKIGNKFKKKNKLKKTKNFPEGEDGEHEH---------------QD 379
            .||...|..|.....|  .|...:|..::|...|.|........|.|.               :.
Yeast   305 KAQLIASHRPYSSLNAFVNTNFNDKDTEENASNKRKRRAAASANESERLLDKITQSIRGYNAIES 369

  Fly   380 YCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAE-------EEDDDEH 437
            ..:.|...|:::....                   .||.   .:.:|..:|       |:|||:
Yeast   370 VIKKCSSYGDLVTSQM-------------------KKWG---VQVEGDNSELDLMNLGEDDDDD- 411

  Fly   438 QEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQR 502
                                                                             
Yeast   412 ----------------------------------------------------------------- 411

  Fly   503 SNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKF 567
             ||||.:.:..|.|:|:...:...|                                :.|:....
Yeast   412 -NDDGNNDNNNSNNNNTAGADATSK--------------------------------EKEDTKAV 443

  Fly   568 EESLDEAD----------------------TRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKP 610
            .|..||..                      |:.|.::...|.|.::|.||
Yeast   444 VEGFDETSAEPTPAPAPAPVERETKRIRNTTKPKVVEDEDDDVDLEAIDD--------------- 493

  Fly   611 EWLIVQRVINHRTARDGSTMYLVKWRELP---YDKSTWEEEGDDIQGLRQAIDY-------YQDL 665
                                      |||   ::...:|||.:|.....:.::|       ..|.
Yeast   494 --------------------------ELPQSEHEDDDYEEEDEDYNDEEEDVEYDDGDDDDDDDD 532

  Fly   666 RAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQ 730
            ..|.|.:.|...|..|:.|||                         .:.|.::.:|..| ...:.
Yeast   533 EFVATRKNTHVISTTSRNGRK-------------------------PIVKFFKGKPRLL-SPEIS 571

  Fly   731 LHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNW 795
            |..||..|||||...:...:..||||:||||||.|.::| ::..|:.:..||.||.||.|||.||
Yeast   572 LKDYQQTGINWLNLLYQNKMSCILADDMGLGKTCQVISF-FAYLKQINEPGPHLVVVPSSTLENW 635

  Fly   796 EREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELIS- 859
            .|||:.:||......|.|....|..:|:                .|.....|::|::|:|.|.:
Yeast   636 LREFQKFAPALKIEPYYGSLQEREELRD----------------ILERNAGKYDVIVTTYNLAAG 684

  Fly   860 --MDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFL 922
              .|.:.|.:.::.|:|.||.|.||::.|:.|..|......::||||||||||||:||..||.|:
Yeast   685 NKYDVSFLKNRNFNVVVYDEGHMLKNSTSERFAKLMKIRANFRLLLTGTPLQNNLKELMSLLEFI 749

  Fly   923 SRDKF-NDLQAFQGEFADVSK-------------EEQVKRLHEMLGPHMLRRLKTDVLKNMPSKS 973
            ..:.| :..::|...|...:|             :|.:.|...|:.|.:|||.|..|||::|.|.
Yeast   750 MPNLFISKKESFDAIFKQRAKTTDDNKNHNPLLAQEAITRAKTMMKPFILRRRKDQVLKHLPPKH 814

  Fly   974 EFIVRVELSAMQKKFY-KFI--------LTKNYEA---LNSKSGGGSCSLINIMMDLKKCCNHPY 1026
            ..|...||:|:|||.| |.|        :.|:.|.   ...||...|.|..|::|.|:|...||.
Yeast   815 THIQYCELNAIQKKIYDKEIQIVLEHKRMIKDGELPKDAKEKSKLQSSSSKNLIMALRKASLHPL 879

  Fly  1027 LF-------------PSAAEEATTAAGG----------------LYEI-----NSLTK------- 1050
            ||             .:..:|...|..|                |:::     |:|:|
Yeast   880 LFRNIYNDKIITKMSDAILDEPAYAENGNKEYIKEDMSYMTDFELHKLCCNFPNTLSKYQLHNDE 944

  Fly  1051 --AAGKLVLLSKMLKQLKA-QNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAI 1112
              .:||:..|.|:||.:.. :..:|||||..|::|||||..|....||:.|:||......||..|
Yeast   945 WMQSGKIDALKKLLKTIIVDKQEKVLIFSLFTQVLDILEMVLSTLDYKFLRLDGSTQVNDRQLLI 1009

  Fly  1113 DRF----NAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVM 1173
            |:|    :.|     :|:|||:|||.||||..|:.|||:|..:|||:|.||..||||:||..:|.
Yeast  1010 DKFYEDKDIP-----IFILSTKAGGFGINLVCANNVIIFDQSFNPHDDRQAADRAHRVGQTKEVN 1069

  Fly  1174 IYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKEDDKE 1236
            |...:|::|:||::.|:||.|:.|...:   ....|..:..:.::.|:|    ||:..:::.:
Yeast  1070 ITTLITKDSIEEKIHQLAKNKLALDSYI---SEDKKSQDVLESKVSDML----EDIIYDENSK 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	13/64 (20%)
		TNG2	<282..422	CDD:227367	32/172 (19%)
		PHD1_CHD_II	380..422	CDD:277006	4/41 (10%)
		PHD2_CHD_II	440..482	CDD:277007	0/41 (0%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	8/69 (12%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	8/63 (13%)
		PLN03142	720..>1234	CDD:215601	199/590 (34%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
FUN30	NP_009383.1	HepA	<571..1093	CDD:440319	191/543 (35%)