Protein Alignment Mi-2 and SMARCA5

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 1114
• Identity: 325/1114 - (29%)
• Similarity: 493/1114 - (44%)
• Gaps: 256/1114 - (22%)

  Fly   634 KWRELPYDKSTWEEE-----GDDIQGLRQAIDYYQDLRAVCTSETTQSRSK------KSKKGRKS 687
            |.:|:.....|:||:     .:..:.|.:..:.:.........:|..|..|      :.||..|.
Human    69 KQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQ 133

  Fly   688 KL---------KVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLR 743
            .|         :.|.:||..:.    ......|::..::||.|::::..  :|..||:.|:|||.
Human   134 NLLSVGDYRHRRTEQEEDEELL----TESSKATNVCTRFEDSPSYVKWG--KLRDYQVRGLNWLI 192

  Fly   744 YSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYC 808
            ..:..||:.|||||||||||:||::.|..:....:..||.:|.||.|||.||..||:.|.|....
Human   193 SLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRS 257

  Fly   809 ITYIGDKDSRAV-IRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAV 872
            :..||||:.||. :|:..|..|                  ::|.:||||::..:.:.....:|..
Human   258 VCLIGDKEQRAAFVRDVLLPGE------------------WDVCVTSYEMLIKEKSVFKKFNWRY 304

  Fly   873 LVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEF 937
            ||:|||||:|:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|
Human   305 LVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWF 369

  Fly   938 AD---VSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEA 999
            ..   :..::.|:|||.:|.|.:|||:|.||.|::|.|.|..:.|.||.||:::|..||.|:.:.
Human   370 DTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDI 434

  Fly  1000 LNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEIN-SLTKAAGKLVLLSKMLK 1063
            |||........|:||:|.|:|||||||||..|      ..|..|..: .|...:||:|:|.|:|.
Human   435 LNSAGKMDKMRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDMHLVTNSGKMVVLDKLLP 493

  Fly  1064 QLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLS 1128
            :||.|..|||||||||::||||||:.....|:|.|:||......||::|:.:|.|.:.:|||:||
Human   494 KLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLS 558

  Fly  1129 TRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKR 1193
            ||||||||||||||.||:|||||||..|:||..|||||||...|.::||:|.|:||||:.:.|:.
Human   559 TRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEM 623

  Fly  1194 KMMLTHLVVRPG-MGGKGAN-FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRG 1256
            |:.|..:|::.| :..:..| ..|.|:..::|.|...:|...:.|    ..|:.:..:|:|.
Human   624 KLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESE----ITDEDIDGILERG--- 681

  Fly  1257 IEEKESWANEYLSSFKVAS------------YATKEEEEEEETEII----------KQDAENSDP 1299
             .:|.:..||.||....:|            |..:.|:..|:.:|.          ::.|..:..
Human   682 -AKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKANYAVD 745

  Fly  1300 AYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTD-------------------GGVVAADTTR 1345
            ||:.:.||....:        ..|..|..||.|..|                   ...:.....|
Human   746 AYFREALRVSEPK--------APKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPR 802

  Fly  1346 DDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVL 1410
            :        .|..:...|..:|....|:.:..|..|.:.|.:|..:
Human   803 N--------PELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQ------------------- 840

  Fly  1411 GF---NARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAE 1472
            ||   |.|....|:.|            |.:|                           |.|:.|
Human   841 GFTNWNKRDFNQFIKA------------NEKW---------------------------GRDDIE 866

  Fly  1473 TFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALE 1537
            ..|..|  ||.:.:.|:....|......::|:.|.|.......|..::....::.||...:...:
Human   867 NIAREV--EGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYK 929

  Fly  1538 AP------PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDK-----------DKDSEKE--- 1582
            ||      ..|.|..|:.|                    :.||:           ||::..:
Human   930 APFHQLRISYGTNKGKNYT--------------------EEEDRFLICMLHKLGFDKENVYDELR 974

  Fly  1583 ---------------KDKTSAEKSE--------VKQEQEAEEDKKPGDVKQENPVEEAAGDTKPS 1624
                           |.:|:.|...        :::|....|:|:..:.|:..|        |||
Human   975 QCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGP--------KPS 1031

  Fly  1625 DAEVKTEVA 1633
            ..:.|.:.|
Human  1032 TQKRKMDGA 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	6/34 (18%)
		PLN03142	720..>1234	CDD:215601	226/520 (43%)
		DUF1087	<1292..1334	CDD:461922	10/41 (24%)
		CHDII_SANT-like	1380..1517	CDD:461920	23/139 (17%)
		CHDCT2	1757..1902	CDD:462358
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		4/13 (31%)
		PLN03142	69..1012	CDD:215601	315/1076 (29%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		9/34 (26%)