Protein Alignment Mi-2 and ATRX

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001184937.1
• Gene: ATRX / 837382
• AraportID: AT1G08600
• Length: 1479
• Species: Arabidopsis thaliana
• Alignment Length: 1566
• Identity: 341/1566 - (21%)
• Similarity: 561/1566 - (35%)
• Gaps: 486/1566 - (31%)

  Fly     4 EEENDDNFQEEEEAQE--DNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKK------GKKR 60
            ||.|:...|::||.|:  ..:.:::.::|.|..:...::||.|...|.......:      ..:.
plant    61 EENNNQGEQKDEEMQDASSRSESSDFNSDEDEQILSRRDDELDLEKPLSEEEIDELISDLLAVES 125

  Fly    61 KTRKGEEKGRKKKKRKKNESEEDSDFVQH------DEEV---------EYPSTSKRGRKRKEEKQ 110
            |..:.:| ..:|:...|.|||...:..|.      ||.|         |:.:|  ......|...
plant   126 KAAEAQE-ALEKESLSKVESEVREELAQALRGDELDEAVAAEMMTFKDEWEAT--LDELETESAT 187

  Fly   111 AAKEKESASSGMPSVEDV--CSAFSVCNVE----------IEYSEEELQSLTTYKAFMHHVRPIL 163
            ..::.:.|...:|.:.::  ..|.:.|..|          .:.::|.::||...:.|:|..||:.
plant   188 LLEQLDGAGIELPKLYEMIESQAPNGCYTEAWKQRAHWVGTQVTKETVESLANAERFLHTHRPVR 252

  Fly   164 QKENP-----------------------------------KIAAPK---LVMLVAAKWRE-FCES 189
            ::...                                   |:.:.|   .|...:.:|.. :..|
plant   253 KRHGKLLEEGASGFLEKKLADGAVKESLAGTSELDWSSLNKVFSEKRDESVSFGSKQWASVYLAS 317

  Fly   190 NPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEE----EEEEEK 250
            .||     .||..|........|  :|.||..:|.:      |....:|::.|.|    ||::..
plant   318 TPH-----QAAAMGLEFPGVNEV--EEIEEIDASLA------DPFLADAIDNERELALTEEQKTN 369

  Fly   251 KPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSA 315
            ..|.|........|       .|:::|..||::..|.:....:..:..|..:..:......:.:.
plant   370 YIRVKEEDDITCDR-------VLQLRLKRKRRKKRSKQVIRCAAENMDDDSVYLDGNNTTPNFAK 427

  Fly   316 DEKEAP-VSSKADNSAPAAQDDG--SGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEH 377
            |:.::| .|::..||....:::|  |.:.|.:....|.|....|:.:......||
plant   428 DQVKSPETSTQVHNSEVNIEENGNFSNSDVDKMTPSTHINVDAKRDDSQNPANNF---------- 482

  Fly   378 QDYCEVCQQGG---------EIILCDTCPRAYHLVCLE---PELDEPPEGKWSCPHCEADGGAAE 430
              .|..|.:..         |:|:|..|.|:     :|   .::|:..|     .|||..|..|:
plant   483 --RCTACNKVAVEVHSHPLLEVIVCMDCKRS-----IEDRVSKVDDSLE-----RHCEWCGHIAD 535

  Fly   431 EEDDDEHQEFCRVCKDGGELLCCDSC-----PSAYHTFCLNPPLDTIPDGDWRCPRCSCPP---- 486
            ..|       ||.|    |.|.|.||     ...|        :.......|.|  |.|.|
plant   536 LID-------CRTC----EKLFCASCIKRNIGEEY--------MSEAQSSGWDC--CCCSPIPLQ 579

  Fly   487 -LTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPL 550
             ||.:.||.:..:.:...:.|..|.|....||                      .:...||:..:
plant   580 RLTLELEKAMRDKKSIELSSDSSSDSSSDNNS----------------------VDTDADVNVTI 622

  Fly   551 MIRSFQRKYDMEEPPKFEESLDEA----DTRYK-RIQRHKDKVGMKANDDAEVLEERFYKNGVKP 610
            ..:...:|       |....:|:|    |||.| .|::.:              :||...
plant   623 SSKKKSKK-------KIRRIIDDAELGKDTRTKIAIEKAR--------------QERLRS----- 661

  Fly   611 EWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQ 675
                :|....::|.   |:|..||  .:|        ||.:::.|..|...|    .|.......
plant   662 ----LQFSARYKTI---SSMGDVK--SIP--------EGAEVEVLGDAHSGY----IVNVVREIG 705

  Fly   676 SRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGIN 740
            ..:.:..:...:||||                                          :|:.||
plant   706 EEAVRVPRSISAKLKV------------------------------------------HQVTGI- 727

  Fly   741 WLRYSW-------------GQGIDTILADEMGLGKTIQTVTFLYSLYKEGHC----RGPFLVAVP 788
              |:.|             .:|:..|||..||||||.|.:.|||:..:   |    ....|:..|
plant   728 --RFMWENIIQSISRVKSGDKGLGCILAHTMGLGKTFQVIAFLYTAMR---CVDLGLKTALIVTP 787

  Fly   789 LSTLVNWEREFELWAPDF---YCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNV 850
            ::.|.||..|||.|.|..   ..|..:||     |.||.....            |...:.|..|
plant   788 VNVLHNWRSEFEKWMPSEVKPLRIFMLGD-----VSRERRFDL------------LTKWRKKGGV 835

  Fly   851 LLTSY-------------ELISMDAACLGSIDWA-VLVVDEAHRLKSNQSKFFRILNSYTIAYKL 901
            .|..|             :|.:....|....|.. :||.||||.:|:.::...:.|.......::
plant   836 FLMGYTNFRNLSLGRGVKDLNAARGICNALRDGPDILVCDEAHIIKNTKADTTQALKQVKCQRRI 900

  Fly   902 LLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADV--------SKEEQVK-------RLHE 951
            .|||:||||||.|.:.:::|:..........|:..|.:.        |..|.||       .|:|
plant   901 ALTGSPLQNNLMEYYCMVDFVREGFLGSSPEFRNRFQNPIENGQHMNSTAEDVKIMNQRSHILYE 965

  Fly   952 MLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFY-KFI-------------LTKN----YE 998
            .|...:.|.....|.|::|.|:.|::.|:||.:|:..| :|:             :.||    |:
plant   966 QLKGFVQRMDMNVVKKDLPPKTVFVISVKLSPLQRILYQRFLELYGFSDGRTDERMRKNFFAAYQ 1030

  Fly   999 AL---------------NSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEAT------TAAGGL 1042
            .|               :||:|... |:::|..|.....|..|...:..::.|      ...|.|
plant  1031 VLAQILNHPGIPQLRSEDSKNGRRG-SIVDIPDDCSSDENIDYNMVTGEKQRTMNDLQDKVDGYL 1094

  Fly  1043 -------------YEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFL----- 1089
                         |:::..   :||::||..:|........:.|:|||....||::|.:|
plant  1095 QKDWWVDLLQKNNYKVSDF---SGKMILLLDILSMSADVGDKALVFSQSIPTLDLIELYLSRVPR 1156

  Fly  1090 EGEQYKY-------ERIDGGITGTLRQEAIDRFNAPGAQQF-VFLLSTRAGGLGINLATADTVII 1146
            .|:|.|:       .||||....:.||:.:||||.|..::. ..|:|||||.|||||..|:.|||
plant  1157 HGKQGKFWKKGKDWYRIDGKTESSERQKLVDRFNEPDNKRVKCTLISTRAGSLGINLYAANRVII 1221

  Fly  1147 YDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGA 1211
            .|..|||..|:||..||.|.||...|..||.:.|.::||:   :.||:      |.:.|:..:..
plant  1222 VDGSWNPTYDLQAIFRAWRYGQKKPVFAYRLMARGTIEEK---IYKRQ------VTKEGLAARVV 1277

  Fly  1212 N-------FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRG----IEEKESWAN 1265
            :       .:|:|:..:..|       :||.|::     :||.|:..:...|    :|:...|..
plant  1278 DRQQVHRTISKEEMLHLFEF-------DDDDEKS-----EAVTEISKQNEAGHSNLVEQAILWTK 1330

  Fly  1266 E----------------------YLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRH 1308
            :                      ::|||.......:|.|||..|:      |..|.|:.|.....
plant  1331 KATLSRVGGDKLMENLLQRHGPNWISSFHEHETLLQENEEERLTK------EEKDMAWEVYRRAL 1389

  Fly  1309 HYEQHQ 1314
            .:|:.|
plant  1390 EWEEVQ 1395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	13/101 (13%)
		TNG2	<282..422	CDD:227367	25/154 (16%)
		PHD1_CHD_II	380..422	CDD:277006	10/53 (19%)
		PHD2_CHD_II	440..482	CDD:277007	11/46 (24%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	11/69 (16%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	12/53 (23%)
		PLN03142	720..>1234	CDD:215601	167/634 (26%)
		DUF1087	<1292..1334	CDD:461922	6/23 (26%)
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
ATRX	NP_001184937.1	PRK02224	<1..>195	CDD:179385	27/136 (20%)
		ADDz_ATRX	481..575	CDD:277252	31/136 (23%)
		HepA	<701..1278	CDD:440319	168/654 (26%)
		DEXHc_ARIP4	719..959	CDD:350827	72/304 (24%)