Protein Alignment Mi-2 and RGD3

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001190085.1
• Gene: RGD3 / 824595
• AraportID: AT3G54280
• Length: 2129
• Species: Arabidopsis thaliana
• Alignment Length: 991
• Identity: 256/991 - (25%)
• Similarity: 409/991 - (41%)
• Gaps: 224/991 - (22%)

  Fly   442 RVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAE-KIITWRWAQRSND 505
            ::.|:...|.|.|  ||......:...:|.:.|.|:...|.:    |||.: |::......||..
plant  1178 KLIKNICSLTCMD--PSETPQASIISSMDIVDDMDFLSSRSN----TGKQKAKVVLASGEDRSKV 1236

  Fly   506 DGPSTSKGSKNSNSRVREYFIKWHNMSY------WHC---EWVPEVQLDVHHPLMIRSFQRKYDM 561
            :|..|.:||:.:   ::...:|:....:      |.|   ..|||:..|          |:|.|:
plant  1237 EGFITRRGSELA---LKHLSLKFGGSLFDKLPKLWECLTEVLVPEIPSD----------QQKIDL 1288

  Fly   562 EEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWL----IVQRVINH- 621
            :     .||:.:.......||        .....|.|:||.     :||..|    .:.:.:.|
plant  1289 K-----IESISDPQVLINNIQ--------VVRSIAPVMEET-----LKPRLLSLLPCIFKCVRHS 1335

  Fly   622 ----RTARDGSTMYLVKWRELPYDKSTWEEE----GD----------------DIQGLRQAIDYY 662
                |.|.....|.:.|........:..|..    ||                .:|||...:..|
plant  1336 HVAVRLAASRCVMTMAKSMTTDVMAAVVESAIPMLGDLTCISGRQGAGMLIGLLVQGLGVELVPY 1400

  Fly   663 QDLRAV----CTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAF 723
            ..|..|    |.|:...|..:...:...:.:.:     .|:....|||...:.||....|| ..|
plant  1401 SPLLVVPLLRCMSDVDSSVRQSVTRSFAALVPM-----LPLARGVPPPVGLSKDLSSNAED-AKF 1459

  Fly   724 LE---------------GTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSL 773
            ||               ...:||..||.||||||.:.....:..||.|:||||||:|....:.|.
plant  1460 LEQLLDNSHIDDYKLCTELKVQLRRYQQEGINWLGFLKRFKLHGILCDDMGLGKTLQASAIVASD 1524

  Fly   774 YKEGHCRG--------PFLVAVPLSTLV-NWEREFELWAPDFYCIT---YIGDKDSRAVIRENEL 826
            ..|.  ||        |.::..| |||| :|..|.|.:. |...::   |:|....|..:||
plant  1525 AAER--RGSTDELDVFPSIIVCP-STLVGHWAFEIEKYI-DLSLLSVLQYVGSAQDRVSLRE--- 1582

  Fly   827 SFEEGAIRGSKVSRLRTTQY-KFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFR 890
                              |: ..||::|||:::..|...|....|...::||.|.:|:.:||...
plant  1583 ------------------QFNNHNVIITSYDVVRKDVDYLTQFSWNYCILDEGHIIKNAKSKITA 1629

  Fly   891 ILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD----------VSKEEQ 945
            .:......::|:|:|||:|||:.||:.|.:||........:.||..:..          .:|:.:
plant  1630 AVKQLKAQHRLILSGTPIQNNIMELWSLFDFLMPGFLGTERQFQASYGKPLLAARDPKCSAKDAE 1694

  Fly   946 -----VKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVR---VELSAMQKKFY-KFILTKNYEALN 1001
                 ::.||:.:.|.:|||.|.:||.::|.|   |::   .:||.:|.|.| :|..:...:.::
plant  1695 AGVLAMEALHKQVMPFLLRRTKEEVLSDLPEK---IIQDRYCDLSPVQLKLYEQFSGSSAKQEIS 1756

  Fly  1002 S--------KSGG-------GSCSLINIMMDLKKCCNHPYLF-------PSAAEEATTAAGGLYE 1044
            |        .||.       .|..:...:..|.|.|:||.|.       |.|::.|....|....
plant  1757 SIIKVDGSADSGNADVAPTKASTHVFQALQYLLKLCSHPLLVLGDKVTEPVASDLAAMINGCSDI 1821

  Fly  1045 INSLTKA--AGKLVLLSKMLKQ-------------LKAQNHRVLIFSQMTKMLDILEDFLEGEQY 1094
            |..|.|.  :.|||.|.::|::             |....||||||:|...:|||:|..|.....
plant  1822 ITELHKVQHSPKLVALQEILEECGIGSDASSSDGTLSVGQHRVLIFAQHKALLDIIEKDLFQAHM 1886

  Fly  1095 K---YERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHND 1156
            |   |.|:||.:....|.|.:..||:..... |.||:|..||||:||.:|||::..:.||||..|
plant  1887 KSVTYMRLDGSVVPEKRFEIVKAFNSDPTID-VLLLTTHVGGLGLNLTSADTLVFMEHDWNPMRD 1950

  Fly  1157 IQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDI 1221
            .||..||||:||...|.::|.:.|.::||:|..:.|.|:.:.:.|:    ..:.|:......|.:
plant  1951 HQAMDRAHRLGQKRVVNVHRLIMRGTLEEKVMSLQKFKVSVANTVI----NAENASMKTMNTDQL 2011

  Fly  1222 LRFGTEDLFKEDDKEEAIHYDDKAVAELLDR---TNRGIEE-----KESW-ANEYLSSFKVASYA 1277
            |     |||...:..:......|..:|..|:   |.:|::.     :|.| .::|...:.::.:.
plant  2012 L-----DLFASAETSKKGGGSSKKGSEDNDQIAGTGKGMKAILGNLEELWDQSQYTEEYNLSQFL 2071

  Fly  1278 TK----EEEEEEETEI 1289
            ||    |.|:.|..:|
plant  2072 TKLNGGENEKREVDDI 2087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007	9/39 (23%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	17/79 (22%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	14/82 (17%)
		PLN03142	720..>1234	CDD:215601	176/600 (29%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
RGD3	NP_001190085.1	HEAT repeat	9..34	CDD:293787
		HEAT repeat	46..73	CDD:293787
		HEAT repeat	541..566	CDD:293787
		HEAT repeat	579..607	CDD:293787
		HEAT repeat	619..668	CDD:293787
		HEAT repeat	677..724	CDD:293787
		HEAT repeat	735..764	CDD:293787
		DUF3535	813..1270	CDD:463447	22/100 (22%)
		HepA	1378..1996	CDD:440319	186/652 (29%)