Protein Alignment Mi-2 and smarcad1b

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_005155692.3
• Gene: smarcad1b / 563175
• ZFINID: ZDB-GENE-091113-61
• Length: 955
• Species: Danio rerio
• Alignment Length: 1119
• Identity: 306/1119 - (27%)
• Similarity: 464/1119 - (41%)
• Gaps: 286/1119 - (25%)

  Fly   208 QARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPT 272
            ::.||..:.||..|.|.||        ...|:.:.:.:.:.|      .||        |..:|.
Zfish    19 ESDSVIPETPETKRPSGSS--------LSTAISDSDSDSDSE------ISG--------SSMMPV 61

  Fly   273 LKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNS-APAAQDD 336
            .|::   .|||.:      ||.|.|.....|.|.::.|:      |..|..|:...| :..||
Zfish    62 RKLR---PRKRKA------ASSADEYSVSDEEEEIVVKT------KRRPTHSRTTRSTSQQAQ-- 109

  Fly   337 GSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQ-----GGEIILCDTC 396
                |..:|.::|.  ......:.||.:.........:...|..|...|:     ||.:...|
Zfish   110 ----PAHQKASETV--TDIAHPSPLKTSGMAAADSVQQRRRQQMCGSSQESDSRKGGRVSAAD-- 166

  Fly   397 PRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDE-----HQEFCRVCKDGGELLCCDSC 456
                         |...||:.|             :|.:.     .::|..:.|
Zfish   167 -------------DSEEEGQRS-------------KDQERMLRKLQRKFPHLNK----------- 194

  Fly   457 PSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRW----AQRSNDDGPSTSKGSKNS 517
                     |...|.:.:.||...           :.:.|.|.    ...|.||...||..:|::
Zfish   195 ---------NELRDVLQEHDWLID-----------DALETLRMFSDLVVESEDDSSQTSTPAKHT 239

  Fly   518 NSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEES--LDEADT---- 576
            . ||              .|..|:.|:.              .:..|||.:.|  ||...|
Zfish   240 R-RV--------------AETRPQAQVT--------------KLSSPPKPKPSRPLDGTRTSQRI 275

  Fly   577 -------RYKRIQRHKDKVGMKA-------NDDAEVLEERFYKNGVKPEWL--IVQRVINHRTAR 625
                   :|..:...::....:|       :.|::..||...|  :|.|.|  .....::..|..
Zfish   276 AKQPILAKYTYVSSEEECSDSEASVVNGLLDSDSDQSEETLSK--LKTEILCFFQSASVDELTLI 338

  Fly   626 DGSTMYLV-KWREL-PYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSK 688
            .|.::... |..|| |:  .||::..|   .:|:......:|.|.|....   :.::..||..|
Zfish   339 AGCSLKKAQKITELRPF--KTWKDLDD---AMRRRNGLSAELLAGCREVL---KEREVVKGLMS- 394

  Fly   689 LKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTI 753
             |.|:...:.::..|...:|....:     .||..|..| .||.|||:.|:|||.......:..|
Zfish   395 -KCEEISVKLIQDVTQVMDKGPGSM-----TQPEILSST-FQLKPYQLIGLNWLVLLHQNKLSGI 452

  Fly   754 LADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSR 818
            ||||||||||||.::||..||:||: .||.|:.||.|||.||.||..||.|.|..:.|.|..|.|
Zfish   453 LADEMGLGKTIQAISFLAHLYQEGN-HGPHLITVPASTLDNWVRELNLWCPSFKVLVYYGSADDR 516

  Fly   819 AVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELI---SMDAA--CLGSIDWAVLVVDEA 878
            ..:|...|:              :..:|  |:::::|.|.   |.|.:  |...:::||.  ||.
Zfish   517 KYMRYEILN--------------QIVEY--NIIVSTYNLAIGNSSDRSLFCKLKLEYAVF--DEG 563

  Fly   879 HRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKF-NDLQAFQGEFADVSK 942
            |.||:..|..:|.|.:....|:||||||||||||.||..||||:..:.| :........|:..|.
Zfish   564 HLLKNMNSLRYRHLMAINAKYRLLLTGTPLQNNLLELMSLLNFIMPNMFSSSTSQIAKMFSMKSS 628

  Fly   943 EEQ-------VKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEAL 1000
            |||       :.....::.|.:|||:|::|||.:|:|.|.:....:|..|::.|..:|.|    |
Zfish   629 EEQSSFERDRITHAKLIMKPFILRRVKSEVLKQLPAKEEQVEFCAMSERQQELYSALLHK----L 689

  Fly  1001 NSKSGGGSCSLINIMMDLKKCCNHPYLF--------------------------PSAAEEATTAA 1039
            ...|.|....|.|:||.|:|..|||.|.                          |:..:|.....
Zfish   690 KHSSNGEKRELTNVMMQLRKMSNHPLLHRQFYTTEKLKAMSKLMLKEPSHRDADPALIKEDMEVL 754

  Fly  1040 GGL--------------YEINS-LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFL 1089
            ...              |::|: :...:|||.||:::|..||.:..||::|||.|.||||||.||
Zfish   755 SDFELHRLCQQYSALHEYQLNTDVLLDSGKLSLLTQLLNSLKEKGDRVVLFSQFTMMLDILEVFL 819

  Fly  1090 EGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPH 1154
            ...:::|.|:||....:.|...||:||. ....||||||||||||||||.:|:.||::|.|.||:
Zfish   820 RHHKHRYNRLDGSTPMSDRIGLIDQFNT-DQDIFVFLLSTRAGGLGINLTSANVVILHDIDCNPY 883

  Fly  1155 NDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELD 1219
            ||.||..|.||:||...|.:.:.::::|:|:.:.::.:||:.|                 :||:
Zfish   884 NDKQAEGRCHRVGQTKTVKVIKLISKDSIEDTMLRIGERKLKL-----------------EQEM- 930

  Fly  1220 DILRFGTEDLFKED 1233
            ...:.|.||...:|
Zfish   931 TATQDGEEDTLPDD 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367	30/145 (21%)
		PHD1_CHD_II	380..422	CDD:277006	9/46 (20%)
		PHD2_CHD_II	440..482	CDD:277007	6/41 (15%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	13/73 (18%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	12/57 (21%)
		PLN03142	720..>1234	CDD:215601	204/568 (36%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
smarcad1b	XP_005155692.3	CUE	179..215	CDD:270465	6/66 (9%)
		ComEA	<329..377	CDD:441164	11/52 (21%)
		HepA	<429..926	CDD:440319	193/520 (37%)