Protein Alignment Mi-2 and smarcad1a

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001018610.2
• Gene: smarcad1a / 557875
• ZFINID: ZDB-GENE-050522-499
• Length: 972
• Species: Danio rerio
• Alignment Length: 1265
• Identity: 312/1265 - (24%)
• Similarity: 482/1265 - (38%)
• Gaps: 412/1265 - (32%)

  Fly    88 QHDEEVEYPSTSKRG-RKRKEEKQAAKEKESAS--SGMPS---VEDVCSAFSVCNVEIEYSEEEL 146
            |.|..|.....|..| ...||.|||.:.|....  ||..|   :|||.|...|..:..: |..:|
Zfish    12 QRDNAVGIHRKSPDGSNSDKENKQAHQRKADGQFPSGKTSRQVLEDVSSDDEVVRMGKD-SASDL 75

  Fly   147 QSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWR----EFCESNPHI-------------Q 194
            |         .|:...::   .||.  ||:.:...|.:    |..|:...:             :
Zfish    76 Q---------QHINKDME---DKII--KLLEIFPQKSKKDLLEVIENTSTLDGAVAHCLMIYGDE 126

  Fly   195 QEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGR 259
            ..||....||     ||...|:|::.|..:.|.:.:.:|       |:.|:||.|:..|.|:...
Zfish   127 DSGGRKDKGG-----RSDDDDQPKKKRKIQRSDSSESED-------EDSEDEESEEPSREKQEAL 179

  Fly   260 GKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASG-----ASERDSDLEFERMLQKSDDS-ADEK 318
            .||.:|   |:|.::.::|....::...:.::|.|     :|...|..|.::..|||..| :.||
Zfish   180 LKKLKR---KLPDIEKEVLRDILKEHDWDYENALGSLLVFSSTDTSSPEDQKSKQKSKSSHSKEK 241

  Fly   319 EAPVSSKADNSAPAAQ---DDGSGAPVVR-----KKAKTKIGNKFKKKNKLKKTKNFPEGEDGEH 375
            ...::.:...|:..::   ...|..|.|.     |..|:.:.....|.:..|:
Zfish   242 TDKITQRPSGSSSLSRWLTAASSHVPEVSSMSALKTQKSALSKSTSKNSSFKR------------ 294

  Fly   376 EHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEF 440
                     ::|.|:.|.|......     |.|:|.           :.|..:.:::.:||
Zfish   295 ---------KRGDEMPLNDVSASED-----EDEIDS-----------DVDSMSDDQDSEDE---- 330

  Fly   441 CRVCKDGGELLCCDSCPSAYH----TFCLNPPLDTIP--DGDWRCPRCSCPPLTGKAEKIITWRW 499
                         ||......    .|..:..||.:.  .|      ||..    ||:|||:.|
Zfish   331 -------------DSISGTLQDKIIQFLQDASLDELALISG------CSIK----KAQKIISLR- 371

  Fly   500 AQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEP 564
                          ..|:...|:|.|.|.:.:|           :|:.|
Zfish   372 --------------PFNTWKDVKEQFFKDNGLS-----------IDLVH---------------- 395

  Fly   565 PKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGST 629
                                    |.|.     ||:||             |.|:
Zfish   396 ------------------------GCKV-----VLKER-------------QVVL---------- 408

  Fly   630 MYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDD 694
                                              ||                 .||..|:
Zfish   409 ----------------------------------DL-----------------MGRCEKI----- 417

  Fly   695 EDRPVKHYTPPPEKPTTDLKKKYE------DQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTI 753
                       .:|.|.|:.:..|      .||..| .:.::|..||:.|:.||.......:..|
Zfish   418 -----------AQKMTKDVTQVIEAGMGSIKQPKVL-NSNLKLQAYQLIGLKWLILLHQHKLSGI 470

  Fly   754 LADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSR 818
            ||||||||||||.:.||..||::| .:||.|:.||.|||.||.||..||.|....:.|.|..:.|
Zfish   471 LADEMGLGKTIQAIAFLAHLYEKG-IKGPHLITVPSSTLDNWVRELGLWCPSLKVLIYYGSVEDR 534

  Fly   819 AVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELI---SMDAACLGSIDWAVLVVDEAHR 880
            ..:|::.|:   |.|             .||:::::|.|.   ..|.:....:.....|.||.|.
Zfish   535 KYLRQDILT---GLI-------------DFNIIVSTYNLTIGNDHDRSLFRKLKLKYAVFDEGHM 583

  Fly   881 LKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQ 945
            ||:..|..:|.|.:....::||||||||||||.||..||||:....|:...:...:.......|:
Zfish   584 LKNMNSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSSEE 648

  Fly   946 VKRLHE--------MLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNS 1002
            ....|:        ::.|.:|||:|::|||.:|.|.|.|....:|..|.|.|..:    ::.|..
Zfish   649 ESSFHKDRIAQARLIMKPFILRRVKSEVLKELPPKMEKIEMCPMSDAQHKLYDIL----FKRLKK 709

  Fly  1003 KSGGGSCSLINIMMDLKKCCNHPYLF--------------------------PSAAEEATTAAGG 1041
            ...|....|.|:||.|:|..|||.|.                          |:..:|.......
Zfish   710 TPNGDKRELCNVMMQLRKMANHPLLHRQYYTSDKLAAMSKAMLKEPTHYDADPALIQEDMEVMSD 774

  Fly  1042 LYEINSLTKA----------------AGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLE 1090
             :|:::|.:.                :||..||:|.|.:||.:..||::|||.|.||||:|..|:
Zfish   775 -FELHNLCREYSSISGFQLEKALILDSGKFALLTKTLAKLKEKGDRVVLFSQFTMMLDIVEILLK 838

  Fly  1091 GEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHN 1155
            ...::|.|:||......|...||::|. ..:.|||||||||||.|||||:|:|||::|.|.||.|
Zfish   839 HLDHQYVRLDGSTPMAERIGLIDKYNT-NPEIFVFLLSTRAGGQGINLASANTVILHDIDCNPFN 902

  Fly  1156 DIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDD 1220
            |.||..|.||:||...|.:.:.::::|:|:.:.:|.:.|:.|
Zfish   903 DKQAEDRCHRMGQTRTVQVIKLISKDSIEDCMLRVGQEKLKL----------------------- 944

  Fly  1221 ILRFGTEDLFKEDDKEEAIHYDDKAVAELL 1250
                 .:|:..::.::.||   .:.:||||
Zfish   945 -----EQDMTTDEGEDGAI---TEQMAELL 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	11/56 (20%)
		TNG2	<282..422	CDD:227367	26/153 (17%)
		PHD1_CHD_II	380..422	CDD:277006	7/41 (17%)
		PHD2_CHD_II	440..482	CDD:277007	6/47 (13%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	14/69 (20%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	2/53 (4%)
		PLN03142	720..>1234	CDD:215601	184/566 (33%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
smarcad1a	NP_001018610.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..76		18/61 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	125..177		18/63 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..333		28/169 (17%)
		ComEA	<348..>381	CDD:441164	13/57 (23%)
		HepA	<439..944	CDD:440319	181/528 (34%)
		DEGH box	579..582		2/2 (100%)