Protein Alignment Mi-2 and Hel89B

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 172/549 - (31%)
• Similarity: 259/549 - (47%)
• Gaps: 79/549 - (14%)

  Fly   729 MQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRG----PFLVAVPL 789
            ::|..||..|||||.:.....:..||.|:||||||:||:..|...:.......    |.||..|.
  Fly  1348 VELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPP 1412

  Fly   790 STLVNWEREFELWAPDFYCITYIGDKDSRAVIRE-NELSFEEGAIRGSKVSRLRT-TQYKFNVLL 852
            :...:|..|.|.:.            |..:|:|. :...|..|.      .:||: ...|.|:::
  Fly  1413 TLTGHWVYEVEKFL------------DQGSVLRPLHYYGFPVGR------EKLRSDIGTKCNLVV 1459

  Fly   853 TSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFH 917
            .||:.:..|......|.:...|:||.|.:|:.::|..:.:......::|:|:|||:|||:.||:.
  Fly  1460 ASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWS 1524

  Fly   918 LLNFLSRDKFNDLQAFQGEF---------ADVSKEEQ------VKRLHEMLGPHMLRRLKTDVLK 967
            |.:||........:.|...|         |..|.:||      ::.||..:.|.:|||:|.||||
  Fly  1525 LFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLK 1589

  Fly   968 NMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCS------------LINIMMDLKK 1020
            ::|.|....:..|||.:|.:.|:....|:.:....|.|..|.:            :...:..|:.
  Fly  1590 DLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQN 1654

  Fly  1021 CCNHPYLFPSAAEEATTAAGGLYEINSL---TKAAGKLVLLSKML-------KQLKAQNHRVLIF 1075
            .||||.|....:||.|.....|...||.   .:.:.||..|.::|       :......||.|||
  Fly  1655 VCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIF 1719

  Fly  1076 SQMTKMLDILE-DFLEGE--QYKYERIDGGITGTLRQEAIDRFNA-PGAQQFVFLLSTRAGGLGI 1136
            .|:..||||:| |.|...  ...|.|:||.:..:.||:.::.||: |...  |.||:|..||||:
  Fly  1720 CQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMVGGLGL 1782

  Fly  1137 NLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLV 1201
            ||..|||||..:.||||..|:||..|||||||...|.:||.:||||:||::..:.|.|::..:.|
  Fly  1783 NLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTV 1847

  Fly  1202 VRPGMGGKGANFTKQELDDILRFGTEDLF 1230
            |      ...|.:.|.:      ||..:|
  Fly  1848 V------SAENASLQTM------GTSQIF 1864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309
		PLN03142	720..>1234	CDD:215601	172/549 (31%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	167/526 (32%)