Protein Alignment Mi-2 and smarca4a

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_853634.1
• Gene: smarca4a / 353295
• ZFINID: ZDB-GENE-030605-1
• Length: 1627
• Species: Danio rerio
• Alignment Length: 1691
• Identity: 412/1691 - (24%)
• Similarity: 648/1691 - (38%)
• Gaps: 557/1691 - (32%)

  Fly    59 KRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMP 123
            :|.|........|..||.|.:|..::...   |::|.....::.|||:::.|
Zfish   443 RRDTALETALNAKAYKRSKRQSLREARIT---EKLEKQQKIEQERKRRQKHQ------------- 491

  Fly   124 SVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCE 188
                            ||....||....:|.:...:...:||....:|.
Zfish   492 ----------------EYLNSILQHAKDFKEYHRSITAKMQKLTKAVAT---------------- 524

  Fly   189 SNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEE--EKK 251
                                                          |....|.|:::|.|  ||:
Zfish   525 ----------------------------------------------YHANTEREQKKENERIEKE 543

  Fly   252 PRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSAD 316
            ..|:.....::|.|          ||:.::|                  |.....:||::|:...
Zfish   544 RMRRLMAEDEEGYR----------KLIDQKK------------------DKRLAYLLQQTDEYVA 580

  Fly   317 EKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYC 381
            .....|  :|..:|.|.:|                     ||.|.||.|  ||..:|
Zfish   581 NLTELV--RAHKAAQALKD---------------------KKKKKKKKK--PENAEG-------- 612

  Fly   382 EVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKD 446
                                                ..|....||...:|...........:..|
Zfish   613 ------------------------------------GAPALGPDGEPLDETSQMSDLPVKVIHVD 641

  Fly   447 GGELLCCDSCPSA--YHTFC-LNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGP 508
            .|::|.....|.|  ..|:. :||..:..|..|                          |.|.|
Zfish   642 SGKILTGMDAPKAGQLDTWLEMNPGYEVAPRSD--------------------------SEDSG- 679

  Fly   509 STSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDE 573
                                                         |.:.:.|.|||..     .:
Zfish   680 ---------------------------------------------SDEEEDDEEEPQP-----SQ 694

  Fly   574 ADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWREL 638
            |.|..|::....|...:...|...::|..  |..|..|:              |::.:
Zfish   695 APTEEKKVIPDPDSEDVSEVDARHIIEHA--KQDVDDEY--------------GNSAF------- 736

  Fly   639 PYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYT 703
                         |:||:   .||....||
Zfish   737 -------------IRGLQ---SYYAVAHAV----------------------------------- 750

  Fly   704 PPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVT 768
                      .:|.|.|.:.|  ...||..|||:|:.||...:...::.||||||||||||||:.
Zfish   751 ----------TEKVEKQSSLL--VNGQLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIA 803

  Fly   769 FLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAI 833
            .:..|.:.....||||:.||||||.||..||:.|||....::|.|..                |.
Zfish   804 LITYLMEFKRLNGPFLIIVPLSTLSNWVYEFDKWAPSVVKVSYKGSP----------------AA 852

  Fly   834 RGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA 898
            |.:.:..||:.  |||||:|:||.|..|...|..:.|..::|||.||:|::..|..::||::.:|
Zfish   853 RRAFLPILRSG--KFNVLVTTYEYIIKDKQVLAKLRWKYMIVDEGHRMKNHHCKLTQVLNTHYLA 915

  Fly   899 -YKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQ----------GEFADVSKEEQ---VKRL 949
             .::|||||||||.|.||:.|||||....|.....|:          ||..|:::||.   ::||
Zfish   916 PRRVLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRL 980

  Fly   950 HEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK------FILTKNYEALNSKSGGGS 1008
            |::|.|.:|||||.:|...:|.|.|::::.::||:|:..|:      .:||...|. :.|..||:
Zfish   981 HKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEK-DKKGKGGT 1044

  Fly  1009 CSLINIMMDLKKCCNHPYLFPSAAE---EATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNH 1070
            .:|:|.:|.|:|.|||||:|....|   |.....||:.:.:.|.:|:||..||.::|.:|:|.||
Zfish  1045 KTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGSDLYRASGKFELLDRILPKLRATNH 1109

  Fly  1071 RVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLG 1135
            :||:|.|||.::.|:||:.....:||.|:||......|...:..||.|..|.|:|||||||||||
Zfish  1110 KVLLFCQMTTLMTIMEDYFAYRNFKYLRLDGTTKAEDRGMLLKNFNDPSHQYFIFLLSTRAGGLG 1174

  Fly  1136 INLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHL 1200
            :||.:||||||:|||||||.|:||..|||||||.|:|.:.|..|.|||||::...||.|:.:...
Zfish  1175 LNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQK 1239

  Fly  1201 VVRPGMGGKGANFTKQE--LDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESW 1263
            |::.||..:.::..::.  |..||.      .:|.|:||....||:.|.:::.|:.   ||.:.:
Zfish  1240 VIQAGMFDQKSSSHERRAFLQAILE------HEEQDEEEDEVPDDETVNQMIARSE---EEFDHF 1295

  Fly  1264 ANEYLSSFKVASYATKE-----EEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGK 1323
            ....|...:..:...|.     ||:|..|.|:|.|||         :.|...|:.:|   :..|:
Zfish  1296 MRMDLDRRREEARNPKRRPRLMEEDELPTWIMKDDAE---------VERLTCEEEEE---KMFGR 1348

  Fly  1324 GKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRL 1388
            |.|.||:|:|:|        :..:..|            ..:.|:|..|:.:::...::..::|.
Zfish  1349 GSRQRKEVDYSD--------SLTEKQW------------LKAIEEGTLDEIEEEVRHKKTTRKRK 1393

  Fly  1389 ERRD-DRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNF 1452
            ..|| |.|.|...:..|.:.:......:|:|.        |.||.:..:..  ...|..|.::..
Zfish  1394 RDRDLDLPGPATPSSSGRSRDKDDDGKKQKKR--------GRPPAEKLSPN--PPSLTKKMKKTV 1448

  Fly  1453 KAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPEL 1517
            .|.:..                     ::|..||  |:.:.:....||::.|      ||   ||
Zfish  1449 DAVIKY---------------------KDGNGRQ--LSEVFIQLPSRKELPE------YY---EL 1481

  Fly  1518 ILKPC------EPVRS-------ALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPAS 1569
            |.||.      |.:||       .|::||..|.......|::.|....:|:.
Zfish  1482 IRKPVDFRKIKERIRSHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIV------------- 1533

  Fly  1570 EKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGD--VKQENPVEEAAGDTKPSDAEVKTEV 1632
                            ..:..:.|:|:.|.||::..||  .::|:.|:|.: :::....:||.::
Zfish  1534 ----------------LQSVFTSVRQKIEKEEEESEGDDSEEEEDDVDEGS-ESESRSVKVKIKL 1581

  Fly  1633 AKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPK 1697
            ::.:..|..|.     ..:|....:          |..|:.|||.:     ||.|.|..::.|.:
Zfish  1582 SRKDKAERGKG-----RRRTGRSSR----------PKPVVSDDDSE-----EDQEEEHSASGSEE 1626

  Fly  1698 D 1698
            |
Zfish  1627 D 1627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	8/52 (15%)
		TNG2	<282..422	CDD:227367	20/139 (14%)
		PHD1_CHD_II	380..422	CDD:277006	1/41 (2%)
		PHD2_CHD_II	440..482	CDD:277007	10/44 (23%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	4/69 (6%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	7/53 (13%)
		PLN03142	720..>1234	CDD:215601	219/538 (41%)
		DUF1087	<1292..1334	CDD:461922	12/41 (29%)
		CHDII_SANT-like	1380..1517	CDD:461920	24/137 (18%)
		CHDCT2	1757..1902	CDD:462358
smarca4a	NP_853634.1	Med15	<65..>360	CDD:312941
		QLQ	198..231	CDD:462622
		Smc	<382..>624	CDD:440809	55/371 (15%)
		HSA	478..550	CDD:214727	20/162 (12%)
		BRK	629..672	CDD:462196	8/42 (19%)
		DEXHc_SMARCA4	743..993	CDD:350820	108/314 (34%)
		PLN03142	762..>1244	CDD:215601	211/500 (42%)
		SnAC	1301..1368	CDD:464219	22/98 (22%)
		Bromo_SNF2L2	1440..1545	CDD:99947	29/165 (18%)