Protein Alignment Mi-2 and smarca2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_073805988.1
• Gene: smarca2 / 334032
• ZFINID: ZDB-GENE-030131-5964
• Length: 1578
• Species: Danio rerio
• Alignment Length: 1292
• Identity: 366/1292 - (28%)
• Similarity: 575/1292 - (44%)
• Gaps: 301/1292 - (23%)

  Fly   487 LTGKAEK----IITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVH 547
            ::||.:|    |.||.         .:|.:..|....|:.:             |.:..:..:..
Zfish   472 ISGKIQKLSKAIATWH---------TNTEREQKKETERIEK-------------ERMRRLMAEDE 514

  Fly   548 HPLMIRSFQRK-----YDMEEPPKFEESLDEADTRYKRIQRHKDK--------------VGMKA- 592
            ........|:|     |.:::..::..:|.|....:|..|..|:|              .||.|
Zfish   515 EGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVYEHKAAQAAKEKKKKRKKKKKEAGDAEGMGAI 579

  Fly   593 NDDAEVLEERFYKNGVKPEWLIVQRVINHRTAR--DGS----TMYLVKWREL--PYD---KSTWE 646
            ..|.|.::|    |....|  :..:||...|.:  .|:    :..|..|.|:  .|:   :|..|
Zfish   580 GPDGEPIDE----NSQMSE--LPVKVIQTETGKVLQGTDAPKSSQLEAWLEMNPGYEVAPRSDSE 638

  Fly   647 EEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVED---DE--DRPVKHYTPPP 706
            |.|.|.:        .:|      .|...||::..:|      ||.|   ||  :...||..
Zfish   639 ESGSDFE--------EED------DEEVVSRAESEEK------KVIDPNSDEVSETAAKHII--- 680

  Fly   707 EKPTTDLKKKYEDQP-------------AFLEGTGMQ--------LHPYQIEGINWLRYSWGQGI 750
            |....|:..:|..|.             |.:|....|        |..|||:|:.|:...:...:
Zfish   681 ESAKQDVDDEYSSQAGQTSSQSYYGVAHAVIERVDKQSTFLINGTLKQYQIQGLEWMVSLYNNNL 745

  Fly   751 DTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDK 815
            :.||||||||||||||:..:..|.:.....||:|:.||||||.||..|.:.|||....|.|.|..
Zfish   746 NGILADEMGLGKTIQTIGLITYLMEHKRLNGPYLIIVPLSTLSNWVYELDKWAPSIVKIAYKGTP 810

  Fly   816 DSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHR 880
                            ::|.|.|.:||:.  |||||:|:||.|..|...|..|.|..::|||.||
Zfish   811 ----------------SMRRSLVPQLRSG--KFNVLITTYEYIIKDKHILAKIRWKYMIVDEGHR 857

  Fly   881 LKSNQSKFFRILNSYTIA-YKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQ---------- 934
            :|::..|..::||::.:| .:||||||||||.|.||:.|||||....|.....|:
Zfish   858 MKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 922

  Fly   935 GEFADVSKEEQ---VKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK------ 990
            ||..|:::||.   ::|||::|.|.:|||||.:|...:|.|.|::::.::||:||..|:
Zfish   923 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSAIQKVLYRHMQGKG 987

  Fly   991 FILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAG---GLYEINSLTKAA 1052
            .:||...|. :.|..||:.:|:|.:|.|||.|||||:|....|......|   |:.....|.:|:
Zfish   988 ILLTDGSEK-DKKGKGGAKTLMNTIMQLKKICNHPYMFQHIEESFAEHLGFPNGIISGPDLYRAS 1051

  Fly  1053 GKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNA 1117
            ||..||.::|.:|||.|||||:|.|||.::.||||:.....:.|.|:||......|...:.:||.
Zfish  1052 GKFELLDRILPKLKATNHRVLLFCQMTSLMTILEDYFGYRNFLYLRLDGTTKSEDRAMLLKKFNE 1116

  Fly  1118 PGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNS 1182
            .|:|.|:|||||||||||:||..||||:|:|||||||.|:||..|||||||.|:|.:.|..|.||
Zfish  1117 EGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNS 1181

  Fly  1183 VEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQE--LDDILRFGTEDLFKEDDKEEAIHYDDKA 1245
            |||::...||.|:.:...|::.||..:.::..::.  |..||.      .:|.:.||....||:.
Zfish  1182 VEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILE------HEEQNMEEDEVPDDET 1240

  Fly  1246 VAELLDRTNRGIEEKESWANEYLSSFKVASYATKE-----EEEEEETEIIKQDAENSDPAYWVKL 1305
            :.:::.|..   :|.|.:....|...:..:...|.     ||:|..:.|:|.|||         :
Zfish  1241 LNQMIARNE---DEFELFMRMDLDRRREDARNPKRKPRLMEEDELPSWILKDDAE---------V 1293

  Fly  1306 LRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGG 1370
            .|...|:.:|.:   .|:|.|.|:.|:|:|        ...:..|            ..:.|||.
Zfish  1294 ERLTCEEEEEKI---FGRGSRHRRDVDYSD--------ALTEKQW------------LRAIEDGN 1335

  Fly  1371 DDDFDDQNGAERKAKRRL----ERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPP 1431
            .::.:::...:|:.:||.    .||:|                 |..|::|:         |.||
Zfish  1336 LEEIEEEIRLKRRKRRRHVDKDVRRED-----------------GDKAKKRR---------GRPP 1374

  Fly  1432 QDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMS 1496
            .:..:..      ..|..:...|.|...:.:                 |:...||  |:.:.|..
Zfish  1375 AEKLSPN------PPKLTKQMNAIVDTVINY-----------------RDISGRQ--LSEVFVQL 1414

  Fly  1497 LIRKKVQEFEHINGYYSMPELILKPC------EPVRSALKQDVAALEAPP------------TGG 1543
            ..||::.|      ||   |||.||.      |.|||...:.|:.||...            .|.
Zfish  1415 PSRKELPE------YY---ELIRKPVDFKKIKERVRSHKYRSVSDLEKDVMLLCHNAQTYNLEGS 1470

  Fly  1544 NVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAE-KSEVKQEQEAEEDKKPGD 1607
            .:.:.:....||..:.....:...:.::.:|.|::.|.|::..|.: |.::.:..|..:||
Zfish  1471 QIYEDSIVLQSVFKSARQKIAREESDDESDDDDEEDESEEESKSVKVKIKLSKRDERGQDK---- 1531

  Fly  1608 VKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKK 1664
                       |..:||..:.|..|:..:..|:.:| ..|.:..::::.:..:.:::
Zfish  1532 -----------GKKRPSRGKAKPVVSDDDSDEDQED-NFKRKMSSQKEARAMMSEEE 1576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	10/73 (14%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	14/64 (22%)
		PLN03142	720..>1234	CDD:215601	223/559 (40%)
		DUF1087	<1292..1334	CDD:461922	11/41 (27%)
		CHDII_SANT-like	1380..1517	CDD:461920	25/140 (18%)
		CHDCT2	1757..1902	CDD:462358
smarca2	XP_073805988.1	None