Protein Alignment Mi-2 and Smarca1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001258119.1
• Gene: Smarca1 / 317575
• RGDID: 1561046
• Length: 1062
• Species: Rattus norvegicus
• Alignment Length: 1182
• Identity: 340/1182 - (28%)
• Similarity: 513/1182 - (43%)
• Gaps: 268/1182 - (22%)

  Fly   558 KYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKAND-DAEVLEERFYKNGVKPEWLIVQRVINH 621
            |.:.|..|::||.:.....:..|.:|.  :..:|..: .|..::....|:...|        :|.
  Rat    73 KSEKEMDPEYEEKMVNIPLKADRAKRF--EFLLKQTELFAHFIQPSAQKSPTSP--------LNM 127

  Fly   622 RTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRK 686
            :.||             |..|.      ||.|.|....||                       |.
  Rat   128 KLAR-------------PRVKK------DDKQSLISVGDY-----------------------RH 150

  Fly   687 SKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGID 751
            .:.:.|:||:      .....:.|:::..::|..|::::|.  .|..|||.|:|||...:..|::
  Rat   151 RRTEQEEDEE------LLSESRKTSNVCVRFEVSPSYVKGG--PLRDYQIRGLNWLISLYENGVN 207

  Fly   752 TILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKD 816
            .|||||||||||:||:..|..|....:..||.:|.||.|||.||..||:.|.|....|.::||||
  Rat   208 GILADEMGLGKTLQTIALLGYLKHYRNFPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKD 272

  Fly   817 SRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRL 881
            .||....:|:...|                 ::|.:||||::..:.:......|..||:|||||:
  Rat   273 VRAAFIRDEMMPGE-----------------WDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRI 320

  Fly   882 KSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD---VSKE 943
            |:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|..   :..:
  Rat   321 KNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQ 385

  Fly   944 EQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGS 1008
            :.|:|||.:|.|.:|||:||||.|::|.|.|..:.:.||.||:::|..||.|:.:.|||......
  Rat   386 KLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDK 450

  Fly  1009 CSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINS-LTKAAGKLVLLSKMLKQLKAQNHRV 1072
            ..|:||:|.|:|||||||||..|      ..|..|..:. :...:||:|.|.|:|.::|.|..||
  Rat   451 MRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDEHIVSNSGKMVALDKLLARIKEQGSRV 509

  Fly  1073 LIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGIN 1137
            |||||||::||||||:.....|:|.|:||......|:|||:.||||.:.:|:|:|||||||||||
  Rat   510 LIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREEAIEAFNAPNSSKFIFMLSTRAGGLGIN 574

  Fly  1138 LATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV 1202
            ||:||.||:|||||||..|:||..|||||||...|.::|.:|.|:||||:.:.|:.|:.|..:|:
  Rat   575 LASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVI 639

  Fly  1203 RPG--MGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWAN 1265
            :.|  :..:.....|:|:..::|.|...:|...:.|    ..|:.:..:|:|.    |:|.:..|
  Rat   640 QQGRLIDQQSNKLAKEEMLQMIRHGATHVFACKESE----LTDEDIVTILERG----EKKTAEMN 696

  Fly  1266 EYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLG------KG 1324
            |.:           ::..|......:.|.|.|       |.:...|.::|.  :.||      ..
  Rat   697 ERM-----------QKMGESSLRNFRMDLEQS-------LYKFEGEDYREK--QKLGTVEWIEPP 741

  Fly  1325 KRVRKQVNY------------TDGGVVAADTTRDDSNWQD------------------------- 1352
            ||.|| .||            ::..|..|.......|.||
  Rat   742 KRERK-ANYAVDAYFREALRVSEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGY 805

  Fly  1353 ---NGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNA 1414
               ...|..:...|..:|....|      |||....:..|.:|     .||.:...|.....||
  Rat   806 KVPRNPELPNPAIAQREEQKKID------GAEPLTPQESEEKD-----KLLTQGFTNWTKRDFN- 858

  Fly  1415 RQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVP 1479
                .|:.|..:||....|.     :.|::.|||......|.::|.....|
  Rat   859 ----QFIKANEKYGRDDIDN-----VAREVEGKSPEEVMEYSAVFWERCNE-------------- 900

  Fly  1480 REGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGN 1544
                                  :|:.|.|.......|..::....::.||...:|..:||.....
  Rat   901 ----------------------LQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLR 943

  Fly  1545 VDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKD--------KTSAEKSEVKQE----- 1596
            :                        :.|..|.|:..:|:|        |...::..|.:|
  Rat   944 I------------------------QYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCV 984

  Fly  1597 QEAEEDKKPGDVKQENPVE-EAAGDT-----KPSDAEVKTEVAKTEPKEETKDP---EVKEEPKT 1652
            :.|.:.:....:|....:| :...:|     :..:.|::......:.|..||.|   :.|.|..|
  Rat   985 RNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMSQKRKAESAT 1049

  Fly  1653 EEKEKEKVDDKK 1664
            |...|:.|...|
  Rat  1050 ESSGKKDVKKVK 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	12/53 (23%)
		PLN03142	720..>1234	CDD:215601	225/519 (43%)
		DUF1087	<1292..1334	CDD:461922	14/59 (24%)
		CHDII_SANT-like	1380..1517	CDD:461920	24/136 (18%)
		CHDCT2	1757..1902	CDD:462358
Smarca1	NP_001258119.1	PLN03142	64..1061	CDD:215601	339/1180 (29%)