Protein Alignment Mi-2 and Smarcad1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_038963492.1
• Gene: Smarcad1 / 312398
• RGDID: 1309640
• Length: 1033
• Species: Rattus norvegicus
• Alignment Length: 1358
• Identity: 315/1358 - (23%)
• Similarity: 504/1358 - (37%)
• Gaps: 479/1358 - (35%)

  Fly     7 NDDNFQEEEEAQEDNAPAAELSNDSDAPLKP-NQNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGR 70
            |.|.|:.|:.::.:.||.|........|..| :.:.|:::.:.|.||
  Rat     5 NLDRFRFEKRSKIEEAPEAAPQPSQPGPSSPISLSAEEENAEGEVSR------------------ 51

  Fly    71 KKKKRKKNESEEDSDFVQHDEEVEYP----STSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSA 131
                    .:..|||..:..|:...|    :.||......:.::..:|....||....|...||:
  Rat    52 --------ANTPDSDVTEKTEDSSVPEPPDNESKASLSCFQNQRTIQEYIDLSSDSEDVSPNCSS 108

  Fly   132 ------FSVCNVEI--EYSEE----------------ELQSLTTYKAFMHHVRPILQKENPKIAA 172
                  ||...|.|  |.||:                ||:.|:..:.........|::..|:.:.
  Rat   109 TVQEKKFSKDTVIIVSEPSEDEESHDLPSATRRNDISELEDLSELEDLKDAKLQTLKELFPQRSD 173

  Fly   173 PKLVML----------VAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSR 227
            ..|:.|          :||...:|           |.||.|             |.:.:.|.||
  Rat   174 SDLLKLIDSTSTMDGAIAAALLKF-----------GDAGGG-------------PRKRKLSSSS- 213

  Fly   228 NEKPDDIYEEAVEEEEEEEEEE-KKPRRKRSGRGKKGRRPSG---KVPTLKIKLLGKRKRDSSDE 288
                     ||.||:|..:::. ||||..|.....:....|.   |..::.:||   :|...:.:
  Rat   214 ---------EAYEEDEANDDQSLKKPRGDRREESNESAEASSNWEKQESIVLKL---QKEFPNFD 266

  Fly   289 EQDASGASERDSDLEFERMLQKSDDS----ADEKEAPVSSKAD--NSAPAAQDDGSGAPVVRKKA 347
            :|:.     |:...|.|.|..::.:|    |::::...:|:::  |....|::........:.|.
  Rat   267 KQEL-----REVLKEHEWMYTEALESLKVFAEDQDVQCASQSEVTNGKEVARNQNYSKNAAKIKM 326

  Fly   348 KTKIG-------NKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCL 405
            |.||.       ||.:|||.....|..   ||.|::
  Rat   327 KQKISMKPQNGFNKKRKKNVFNPKKAV---EDSEYD----------------------------- 359

  Fly   406 EPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDG--GELLCCDSCPSAYHTFCLNPP 468
                            ..:|.|::.:||....:|   |.:||  |::|         | |..:..
  Rat   360 ----------------SGSDAGSSLDEDYSSCEE---VMEDGYKGKIL---------H-FLQDAS 395

  Fly   469 LDTIPDGDWRCPRCSCPPLTGKAEKIITWR----W----AQRSNDDGPSTSKGSKNSNSRVREYF 525
            :..:.    ..|:||    ..||:|||..|    |    .:.|..:|.|             |..
  Rat   396 IGELT----LIPKCS----QKKAQKIIELRPFNNWETLFTKMSKINGLS-------------EDL 439

  Fly   526 IKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGM 590
            |       |:|:
  Rat   440 I-------WNCK----------------------------------------------------- 444

  Fly   591 KANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGL 655
                  .|::||.          :|.|::|.
  Rat   445 ------TVIQERD----------VVIRLMNK---------------------------------- 459

  Fly   656 RQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQ 720
                  .:|:....|.:.|.      ..|......:|                           |
  Rat   460 ------CEDISNKLTKQVTM------LTGNGGGWNIE---------------------------Q 485

  Fly   721 PAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLV 785
            |:.| ...:.|.|||..|:|||......|::.|||||||||||||.:.||..|::||: :||.|:
  Rat   486 PSLL-NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLI 548

  Fly   786 AVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNV 850
            .||.||:.||.||..||.|....:.|.|.::.|..||.|                :......:||
  Rat   549 VVPASTIDNWLREVNLWCPTLNVLCYYGSQEERKQIRFN----------------IHNKYEDYNV 597

  Fly   851 LLTSYELI---SMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNL 912
            ::|:|...   |.|.:....:.....:.||.|.||:..|..::.|.:.....:|||||||:||||
  Rat   598 IVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNL 662

  Fly   913 EELFHLLNFL-----------------SRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRR 960
            .||..||||:                 |:.|..|.|:       :.::|::....:::.|.:|||
  Rat   663 LELMSLLNFVMPHMFSSSTSEIRRMFSSKTKPADEQS-------IYEKERIAHAKQIIKPFILRR 720

  Fly   961 LKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHP 1025
            :|.:|||.:|.|.:.|....:|..|::.|..:..:..:::|:..  .:..:.|:||.|:|..|||
  Rat   721 VKEEVLKLLPPKKDQIELCAMSEKQEQLYSGLFNRLKKSINNLE--KNTEMCNVMMQLRKMANHP 783

  Fly  1026 YLF-------------------PSAAE----------EATTAAGGLYEINSLTKA---------- 1051
            .|.                   |:..|          |..|.    :|::.|.|.
  Rat   784 LLHRQYYTAEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTD----FELHVLCKQYQHINSYQLD 844

  Fly  1052 ------AGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQE 1110
                  :||...|..:|.:||.:..||::|||.|.||||||..|:..|::|.|:||....:.|..
  Rat   845 MDLILDSGKFRTLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIH 909

  Fly  1111 AIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIY 1175
            .||.||. ....|||||||:||||||||.:|:.||::|.|.||:||.||..|.||:||..:|::.
  Rat   910 LIDEFNT-DMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVI 973

  Fly  1176 RFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKED 1233
            :.:::.::||.:.::.::|:.|                 :|::..:...|..||...|
  Rat   974 KLISQGTIEESMLKINQQKLKL-----------------EQDMTTVDEGGHSDLLDSD 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	14/80 (18%)
		TNG2	<282..422	CDD:227367	24/152 (16%)
		PHD1_CHD_II	380..422	CDD:277006	0/41 (0%)
		PHD2_CHD_II	440..482	CDD:277007	8/43 (19%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	14/77 (18%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	3/53 (6%)
		PLN03142	720..>1234	CDD:215601	186/579 (32%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
Smarcad1	XP_038963492.1	HepA	<484..995	CDD:440319	181/569 (32%)