Protein Alignment Mi-2 and rad-54.B

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001255913.1
• Gene: rad-54.B / 190999
• WormBaseID: WBGene00013792
• Length: 833
• Species: Caenorhabditis elegans
• Alignment Length: 683
• Identity: 198/683 - (28%)
• Similarity: 300/683 - (43%)
• Gaps: 139/683 - (20%)

  Fly   731 LHPYQIEGINW----LRYSWGQ---GIDTILADEMGLGKTIQTVTFLYSLYK--------EGHCR 780
            |.|:|..||.:    ||...|:   |...||||:|||||::||:...::|.|        ...|
 Worm   206 LRPHQKSGIQFIFDRLRRGSGKNGGGGGAILADDMGLGKSLQTMAATWALLKGSKTAQQLANSC- 269

  Fly   781 GPFLVAVPLSTLVNWEREFELW-----APDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSR 840
               |:.||.|.:.||:.||:.|     .|              |||          |:..:.::.
 Worm   270 ---LIIVPSSLVNNWKAEFDKWWRLMRFP--------------AVI----------ALTANDITT 307

  Fly   841 LRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTG 905
            .::|......|:.||:|.......|..|.:.|:|.||.|:||:...|..:.|.|..|..:|:|||
 Worm   308 YQSTIKLMPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTG 372

  Fly   906 TPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDV-LKNM 969
            ||:||:.||.:.||:|:....|..:..|:...:|  :.||   |:|::...||||...|| ||::
 Worm   373 TPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSD--RPEQ---LNELIDECMLRRTAADVDLKHL 432

  Fly   970 PSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEE 1034
            |.|.|:|:....|.:||..:..|.  :|..      |.:.|||.....|   .|||.|......|
 Worm   433 PEKHEYILFCAASPIQKHVHSEIC--DYMT------GDALSLIFFARQL---ANHPKLLLDNLRE 486

  Fly  1035 AT------------TAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILED 1087
            .|            .|..|.:......|.:|||..|..|:|..:......:|.|...:.||:::.
 Worm   487 KTEKSKAHKHSPLLLAFDGAHMPRGGVKESGKLTALVDMIKCFRLLQECTVIVSNYIETLDMIQQ 551

  Fly  1088 FLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWN 1152
            ..|...:|..|:||......||:.:..||.......:|||||:|||:|:||..|..::::|||||
 Worm   552 LCEYLNFKVLRLDGKTQVPDRQKLVRTFNDHRDPSNIFLLSTKAGGVGLNLIGASRLVLFDSDWN 616

  Fly  1153 PHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQE 1217
            |.||.||.:|..|.||.....|||.:|..::||::.|...:|..|..::....:|...|.||.::
 Worm   617 PANDQQAMARIWRDGQVRPCHIYRLITTGTIEEKMLQRQIKKTGLGCVIDAIEVGDTIATFTDED 681

  Fly  1218 LDDILRF-------GTEDLF---------------KEDDKEEAIHYDDKAVAELLDRTNRGIEEK 1260
            |.||..|       .|.||.               :|||.::.:..|    ||.:|::.: |::.
 Worm   682 LKDIFTFTGSATECNTHDLCECPCDGCGMLENEMDEEDDGDDVVEND----AEKIDKSGK-IDKI 741

  Fly  1261 ESWANEYLSSFKVASYATKEEEEEEETEIIKQDA----ENSDPAYWVKLLR-----------HHY 1310
            :|..:|         .|..||.|.:.|:.:.:|:    |.:.||.....||           .|:
 Worm   742 DSDDDE---------EADDEELEADVTDEVVEDSQEPPEATKPAVAAAGLRTIASLAELSRWRHF 797

  Fly  1311 EQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADT 1343
            .....|.....           .|:.|:...||
 Worm   798 SPRHADTWHHF-----------MTNAGLSQVDT 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309
		PLN03142	720..>1234	CDD:215601	172/557 (31%)
		DUF1087	<1292..1334	CDD:461922	8/56 (14%)
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
rad-54.B	NP_001255913.1	HepA	<206..661	CDD:440319	159/498 (32%)