Protein Alignment Mi-2 and btf-1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_496802.2
• Gene: btf-1 / 174965
• WormBaseID: WBGene00000274
• Length: 1649
• Species: Caenorhabditis elegans
• Alignment Length: 897
• Identity: 223/897 - (24%)
• Similarity: 362/897 - (40%)
• Gaps: 220/897 - (24%)

  Fly   494 IITWR--WAQRSNDDGPSTSKGSKNSNSRVREYFIK---WHNMS-----YWHCEWVPEV------ 542
            ||:.|  |. :..|||...|.|..::.||..|.|:.   ..|.|     |.|.:...:|
 Worm   855 IISMRRIWG-KETDDGFEESSGMISAESRNAELFLNILCQFNASQLAEFYCHFDLSEDVDLNTFL 918

  Fly   543 -QLDVHHPLMIRSFQRKYDM-----------EEPP---KFEESLDE------ADTR---YKR--- 580
             :|::|:.|..|...|..|.           |:|.   .|.::::.      .||.   |.|
 Worm   919 TRLELHNSLWNRVGSRLSDQSADKIFSLVPSEDPAIRYAFAKAIETFFKSSCGDTLSKCYNRLVV 983

  Fly   581 IQRHKDKVGMKANDDAEV-----LEERFYKNGVKPEW-LIVQRVI------NHRTARD--GSTMY 631
            :.:..|.|..:.: ..||     :.:..|.||    | .::..||      ...|.||  |....
 Worm   984 LSKDLDNVNSRLS-AVEVFLRLCMMDTRYLNG----WATLLAPVIFPLLADQCETVRDAAGEAFR 1043

  Fly   632 LVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSK-------KGRKSKL 689
                |.:|.  .|.|.....|:|:.|.:                 .:|||:       .|..|.|
 Worm  1044 ----RLIPV--ITLENPDFSIEGMSQEL-----------------LAKKSEYSNFINVLGSPSSL 1085

  Fly   690 KVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTIL 754
                            |.....|::..::        |.| |..||:|||.|:|:....|:..||
 Worm  1086 ----------------PRVIRADIRGGFD--------TSM-LREYQLEGITWIRFLRTYGLHGIL 1125

  Fly   755 ADEMGLGKTIQTV-TFLYSL----YKEGH-CRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIG 813
            ||:||||||:||: :...|:    ..|.| |.   |:..|.:.:.:|..|:..:.|
 Worm  1126 ADDMGLGKTLQTMCSIALSVDRDEMSEFHRCS---LIVCPRTLVDHWCLEWNRFFP--------- 1178

  Fly   814 DKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEA 878
                :.|.....|:...||         ......::.|.|:|   .||..      |..:|:||.
 Worm  1179 ----QRVPASKNLTRCHGA---------EICVIAYDELKTAY---MMDRV------WNYIVLDEG 1221

  Fly   879 HRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEF------ 937
            |.:::::.:.::..:......:|:|:|||:||:..:|:.|..:|........:.|:.:|
 Worm  1222 HVMRNSKLRAWKFASQLVGKSRLILSGTPVQNSPADLWSLFAWLMPGYLGSEKQFRSQFLKKIMK 1286

  Fly   938 --------ADV-SKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFIL 993
                    ||: :....:.:||:::.|.::|||||:|||.:|.|:......||:..||:.|:|::
 Worm  1287 CRLPKANEADLKAGSAAISQLHKLVLPFVMRRLKTEVLKELPEKNVQDYECELTEDQKEIYRFVV 1351

  Fly   994 TKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAA--GKLV 1056
            .:   ..:|:...|..||:. ::.|:|..:|..|    ..:.....|....|.|...||  ||:.
 Worm  1352 DR---CTSSQEDVGLSSLVT-LITLRKLTDHTKL----VHDTLAKIGAPQYILSKALAAKSGKME 1408

  Fly  1057 LLSKMLKQ-------------------LKAQNHRVLIFSQMTKMLDILEDFLE----GEQYKYER 1098
            .|.::|.:                   |.|..||.|||.|......::.|.|:    |....:..
 Worm  1409 ALKQLLIECEICKNPDEEVEQPEDLGGLVASGHRALIFCQWKTSAKLVSDALKSGEFGSVVSHLV 1473

  Fly  1099 IDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRA 1163
            :||.:....|.:.::|||...... |.:|:|..||:|:||..|||||..|.||||..|:||..||
 Worm  1474 LDGSVPAGDRMKMVNRFNEDKTID-VLILTTHVGGVGLNLTGADTVIFLDHDWNPMKDLQAIDRA 1537

  Fly  1164 HRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRF---- 1224
            ||:||...|.:||.:|:.:|||:|..:||.|:.....::    |....:....|..:::..
 Worm  1538 HRLGQTRNVNVYRLITQGTVEEKVMSLAKFKLNTAQALI----GADNTSMMTMETGELMNMFTLD 1598

  Fly  1225 GTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASY 1276
            |.|...|....|.|.....|:..     ....::....|.......|:|.|:
 Worm  1599 GDEAKKKPGGGEPAAKKSKKSTG-----APEEVDLASMWDESQYDDFQVDSF 1645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	22/79 (28%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	14/62 (23%)
		PLN03142	720..>1234	CDD:215601	156/563 (28%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
btf-1	NP_496802.2	DUF3535	<572..>792	CDD:463447
		HepA	<1102..1577	CDD:440319	149/521 (29%)