Protein Alignment Mi-2 and chd-1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_491994.2
• Gene: chd-1 / 172432
• WormBaseID: WBGene00010369
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1770
• Identity: 513/1770 - (28%)
• Similarity: 771/1770 - (43%)
• Gaps: 476/1770 - (26%)

  Fly   223 SRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSD 287
            |.|..:.:||:..:|.|.|||..|                                |....:.:|
 Worm     7 SSSGSDAEPDEKTDEPVREEENPE--------------------------------GNSTSEDND 39

  Fly   288 EEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIG 352
            |::.|:.:.|..||        :||||.|..|...||:.|..||..:::.:.......:...:..
 Worm    40 EKEKAADSPESSSD--------QSDDSDDASENSSSSEPDEPAPKKKNNNNRGMDAETRKLLENE 96

  Fly   353 NKFKKKNKLKKTKNFP-----EGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEP 412
            |.|::..:.|:..:.|     |.:..|.:..|..:..:...:.::..| .:|..:|
 Worm    97 NYFRRSKRSKRQDDSPSDNSEESQSSEDDWDDRRKPRRTVTKKVVKQT-KKAVSVV--------- 151

  Fly   413 PEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDW 477
                 .....:.:...||:..||:        .|..::|..|..|:.
 Worm   152 -----KRKSVKGNVNYAEKNSDDD--------IDDDDVLEWDEEPAV------------------ 185

  Fly   478 RCPRCSCPPLTGKAEKIITWRWAQRSNDDGPST-----SKGSKN----SNSRVREYFIKWHNMSY 533
              |......||...|::|.||..........:|     .||..|    .:...:::|:||...|:
 Worm   186 --PAEGPAILTETVERVIKWRHGVPGATGSATTCYNIADKGDPNDQIPGDKTEQQFFVKWTGWSH 248

  Fly   534 WHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEV 598
            .|..|..|..|.:.:...::..|                      ..:::.|:....|.:.|.|.
 Worm   249 LHNTWESENSLALMNAKGLKKVQ----------------------NYVKKQKEVEMWKRSADKEY 291

  Fly   599 LE----ERFYKNGVKPEWLIVQRVINHRTAR----DGS--TMYLVKWRELPYDKSTWEEEGDDIQ 653
            :|    |:.....:..|:..|:||:.|:|:|    |||  |.||:||..|||...|||:|  .:.
 Worm   292 IEFFECEQQMAEELCEEYKKVERVVAHQTSRDRAADGSMATEYLIKWSGLPYSDCTWEDE--KMV 354

  Fly   654 GLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYE 718
            ...|...||..:      |..:|.:|.|...||          ||              ..:|:|
 Worm   355 APEQIKAYYHRI------ENLKSPNKNSNVLRK----------RP--------------KFEKFE 389

  Fly   719 DQPAFLEGTGMQLH---PYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCR 780
            ..|.||:..|...|   .||:||:||:.|:|.:|..:|||||||||||||:::.|.||:......
 Worm   390 SMPDFLKTDGESTHKLRDYQLEGLNWMVYAWCKGNSSILADEMGLGKTIQSISLLASLFHRYDLA 454

  Fly   781 GPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQ 845
            ||:||.|||||:..|::||..|||:...:.|:||..||.:||:.|. |..|           |.:
 Worm   455 GPYLVVVPLSTMAAWQKEFAQWAPEMNLVVYMGDVVSRDMIRQYEW-FVGG-----------TKK 507

  Fly   846 YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQN 910
            .|.|.:||:||::..|.|.|.|||||.|:||||||||:::|..::.|..:...:|||:|||||||
 Worm   508 MKINAILTTYEILLKDKAFLSSIDWAALLVDEAHRLKNDESLLYKSLTQFRFNHKLLITGTPLQN 572

  Fly   911 NLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEF 975
            :|:||:.||:|:..:||:..:.|:....: |..:.:..||:.|.|.:|||:|.||.|::|.|:|.
 Worm   573 SLKELWALLHFIMPEKFDCWEEFETAHNE-SNHKGISALHKKLEPFLLRRVKKDVEKSLPPKTEQ 636

  Fly   976 IVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAG 1040
            |:||:::|.||:|||:||||||..|:....|.....:|::|:|||||||..|..........|.|
 Worm   637 ILRVDMTAHQKQFYKWILTKNYRELSKGVKGSINGFVNLVMELKKCCNHASLTRQYDHIYDDAQG 701

  Fly  1041 GLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITG 1105
            .|.:   |.|::|||:||.|:|.:||.:.|||||||||..|||||:::|:..::..:|:||.:..
 Worm   702 RLQQ---LLKSSGKLILLDKLLCRLKDKGHRVLIFSQMVMMLDILQEYLQLRRFPSQRLDGSMRA 763

  Fly  1106 TLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQAN 1170
            .||::|:|.:||||:..|.||||||||||||||||||||||:||||||.||:||.||||||||..
 Worm   764 DLRKQALDHYNAPGSTDFAFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAMSRAHRIGQTK 828

  Fly  1171 KVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV-RPGMGGK-----------GANFTKQELDDILR 1223
            .|.|||.||:.||||.:.:.||||::|.|||: |....||           ...|.||||..||:
 Worm   829 TVNIYRLVTKGSVEEEIVERAKRKLVLDHLVIQRMDTTGKTVLSKNATASGSVPFDKQELSAILK 893

  Fly  1224 FGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKES-----WANEYLSSFKVASYATKEEEE 1283
            ||..:||||.:.||.....|      :||...|.|.:|:     ..||.|||||.|::|..||::
 Worm   894 FGAVELFKEKEGEEQEPEVD------IDRILMGAETREAEEEVMKENELLSSFKYANFAIDEEKD 952

  Fly  1284 -----EEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADT 1343
                 :|...||.::..|       ::|.   |:..:::. .:....|.|||   ....||
 Worm   953 IAAATDEWAAIIPEEDRN-------RILE---EERMKELA-EMNLAPRQRKQ---PIPQVV---- 999

  Fly  1344 TRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIE 1408
                                 .|:||.||:.:|..|.::|.|                .||
 Worm  1000 ---------------------EDDDGDDDEEEDDTGKKKKKK----------------AVG---- 1023

  Fly  1409 VLGFNARQRKSFLNAIMRYGMP-------PQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEP 1466
              .|...:.|.|:.:..::.||       .|||        :|...|....|..|. .:...|:.
 Worm  1024 --NFTIPEIKRFIKSFRKFSMPLNRLEEIAQDA--------ELEEHSTDEMKKLVE-SLSEACKK 1077

  Fly  1467 GAD-------NAETFADGVPREGLSRQ---HVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKP 1521
            .||       |.:..|....::.:.|:   |...       :..|..|..|..         |||
 Worm  1078 AADEFDSNEKNGDAGAAESEKKDIERKFKFHTCD-------VNLKQIERSHAE---------LKP 1126

  Fly  1522 CEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPAS-EKGEDKD----KDSEK 1581
            ...:.                    ||..|..|..|       ||.|. :||.|.|    .||..
 Worm  1127 LHEIL--------------------KSEETKTSFKP-------PANAKLQKGWDVDWSRPDDSAL 1164

  Fly  1582 ---------------EKDKT--SAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVK 1629
                           :.|.|  .|:|..:|     ::.|||                :..:.:|:
 Worm  1165 LLGVWKYGYGSWEAIKMDPTLGLADKIFIK-----DKTKKP----------------QGKNLQVR 1208

  Fly  1630 TE-VAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPP------TTVIDDDDDDVMIVKEDGE 1687
            .: :.|...|::.|        .||:||:::..|..|:.|      |..:..:.:.    |:..:
 Worm  1209 VDYLLKLMSKDKVK--------TTEKKERKRKADDVPVGPEKKKRHTNNVPQEGEK----KKKEK 1261

  Fly  1688 LEKPSASSPKDQKAVAAATSAATGATGKGA-EDS-----LEVLK-----RKFMFNIADGGFTELH 1741
            .|:.::||.|||.|:.:...:..|    || |||     ||.:|     .|:|..:.:.
 Worm  1262 KEEKNSSSLKDQLALLSIDKSLYG----GALEDSSAKPFLECVKLCMPVHKYMKKLKEA------ 1316

  Fly  1742 TLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKG-NF 1805
                  ::|.....|.:...|..|.:|            ::::     .:|.:..|.::.|. |:
 Worm  1317 ------QEAKNQADEAKYLTRLGDSFL------------ENLE-----TLIKKKPKTNIRKWYNY 1358

  Fly  1806 LEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQD--PSHPAMSLNARFAEVECLAESHQHLSK 1868
            |.|   ||. :|.|.|...:.:.      |.::..|  .:|               ...|.|.||
 Worm  1359 LWI---FLC-KFTLREPGEMADR------YRSITSDKHKNH---------------HHHHHHKSK 1398

  Fly  1869 ESLAGNKPANAVLHK 1883
            |    .||..|..||
 Worm  1399 E----EKPKEAKDHK 1409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367	27/144 (19%)
		PHD1_CHD_II	380..422	CDD:277006	3/41 (7%)
		PHD2_CHD_II	440..482	CDD:277007	5/41 (12%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	18/78 (23%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	25/59 (42%)
		PLN03142	720..>1234	CDD:215601	257/528 (49%)
		DUF1087	<1292..1334	CDD:461922	7/41 (17%)
		CHDII_SANT-like	1380..1517	CDD:461920	26/153 (17%)
		CHDCT2	1757..1902	CDD:462358	27/130 (21%)
chd-1	NP_491994.2	CD1_tandem_CHD1-2_like	194..275	CDD:349313	18/102 (18%)
		CD2_tandem	308..363	CDD:349306	23/56 (41%)
		PLN03142	404..1245	CDD:215601	352/1004 (35%)
		DUF4208	1298..1367	CDD:464035	17/101 (17%)