Protein Alignment Mi-2 and LOC1273471

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_312449.5
• Gene: LOC1273471 / 1273471
• VectorBaseID: AGAMI1_011781
• Length: 1503
• Species: Anopheles gambiae
• Alignment Length: 1858
• Identity: 366/1858 - (19%)
• Similarity: 609/1858 - (32%)
• Gaps: 724/1858 - (38%)

  Fly    28 SNDSDAPLKPNQNDEDDDYD------PEDS--------------RRKKKGKKRKTRKGEEKGRKK 72
            |.::.||::.|.:...|:.|      |.|.              |....||..:..||||:.:..
Mosquito    84 SGEAAAPVEKNNSPAPDEQDAARVDSPTDDTVKTIRLVSLDKLLRPSLVGKVPEEGKGEEEKQPH 148

  Fly    73 KKR--------KKN--------ESEEDS--DFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESAS 119
            :.|        |||        :|||:|  .:|     ::..||       |.|..|.||..:||
Mosquito   149 ESRRSSSNRAGKKNISIIELSDDSEEESLQQYV-----IDKSST-------KSENDAGKEGVAAS 201

  Fly   120 SGMPSVEDVCSAFSV-----------CNVEIEYSEEELQ--------SLTTYKAFMHHVRPILQK 165
            ...||.....|..|.           .:..:..:.:||.        .|:|.|| .|.::.|...
Mosquito   202 PPPPSSASKVSGKSAKKATSGEGRAKSSTLLPLATKELSIVVTPLPADLSTIKA-THGLKEIRDH 265

  Fly   166 ENPKIA--APKLVML-------VAAKWREFCESNPHIQQEGGA-----AGSGGSAGQARSVTGDE 216
            .|..|.  .|....|       .|||.::.  ::|..:|:..|     |.:|.::.|.|
Mosquito   266 RNNVIETFVPNSSRLSNRTRKNKAAKRKKM--ASPEEEQQSDAVALENADTGSNSKQHR------ 322

  Fly   217 PEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKR 281
              :...:..|.||...|:.|.:...|.:.:....:.|.|          ....:|..|...|..|
Mosquito   323 --QEDDNGGSGNENQSDVEEGSKRNESDSDAPITRGRNK----------SKTSIPKEKKNTLITR 375

  Fly   282 KR---DSSDEEQD--------ASGASERD----SDLEFER---MLQKSDDSADEKEAPVSSKADN 328
            ||   ..||||||        |:|.:::|    ||.||.:   ...:|..:|:..:...:.....
Mosquito   376 KRRAVSDSDEEQDTGKPSTPVANGNTDKDSESGSDFEFAKRNTATSRSQRAAERSKRGRAGATKA 440

  Fly   329 SAPAAQDDGSGAPVVRKKAKTKIGNKF---KKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEI 390
            :||:|.:..:.....::|      |.|   ||:.::::......||||:
Mosquito   441 AAPSADEASNDEEADKEK------NDFQTRKKRTRIRRNSTSSSGEDGK---------------- 483

  Fly   391 ILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDS 455
                                                                             
Mosquito   484 ----------------------------------------------------------------- 483

  Fly   456 CPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSR 520
                                          |::.:.::..|.:  :.|:.:|.|.:||.||
Mosquito   484 ------------------------------PVSKRKKRKQTKK--KNSDSEGDSPNKGRKN---- 512

  Fly   521 VREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHK 585
                                           ||...:|.|:||..|..|. :|.:.:.:..:|.|
Mosquito   513 -------------------------------IRKLLKKSDLEETTKNAEQ-EERERKQRIAERQK 545

  Fly   586 DKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGD 650
                         |..:.|..  |||
Mosquito   546 -------------LYNQVYDE--KPE--------------------------------------- 556

  Fly   651 DIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKK 715
                            ..||.:               :|.::.||:         .::|..::.:
Mosquito   557 ----------------EACTLD---------------QLVLDFDEE---------TKEPLLEVDR 581

  Fly   716 KYEDQPAFLEGTGMQLHPYQIEGINWL---------RYSWGQGIDTILADEMGLGKTIQTVTFLY 771
            |..          .||.|:|..||.::         :.:..:|...|||..||||||:|.||..:
Mosquito   582 KLV----------KQLKPHQANGIKFMFDACFESLEQMNQSKGSGCILAHCMGLGKTLQVVTLAH 636

  Fly   772 SLYKEGHCRG--PFLVAVPLSTLVNWEREFELWAP--------DFYCITYIGDKDSRAVIRENEL 826
            :|.......|  ..||..||||::||..||.:|..        :.|.|:...|.    |.|.|:|
Mosquito   637 TLLASADLTGVERILVVCPLSTVLNWANEFHMWMKHVKKGTEVEVYEISKYKDN----VTRANKL 697

  Fly   827 S--FEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWA--VLVVDEAHRLKSNQSK 887
            .  ..||.:........|...   |...|.......::.....||..  ::|.||.|.||:.::.
Mosquito   698 MEWHNEGGVMIMGYDMFRNLA---NPTATRIRKKVRESLQTSLIDPGPELIVCDEGHLLKNEKTS 759

  Fly   888 FFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAF---------QGEFADVSKE 943
            ..:.:|..:...:::|||||:|||::|.:.::.|:..........:         .|::.|.:..
Mosquito   760 LSQAVNRISTMRRIVLTGTPIQNNMKEYYCMVQFVKPKLLGTYTEYMNRFVNPITNGQYTDSTPY 824

  Fly   944 E-QVKR-----LHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNS 1002
            : |:.|     ||::|...:.||....:...:|.|.||:|.::|:.:|...||:.:    |.:..
Mosquito   825 DIQLMRKRAHVLHKLLDGCVQRRDYAVLAPFLPPKLEFVVSIKLTPLQSTLYKYYM----ENMAG 885

  Fly  1003 KSGGG------SCSLINIMMDLKKCCNHP--------------------------------YLFP 1029
            |....      |..|.|...:|::...||                                ::..
Mosquito   886 KRNDDDPTLKRSSMLFNDFQNLQRIWTHPRVLRYNSDRYEIKQQRKRDLDSENESEGSMKDFIDD 950

  Fly  1030 SAAEEATTAA---------------------------------------------GG-------- 1041
            ....|:|.|:                                             ||
Mosquito   951 EDTAESTPASSDSESDVQSVHDDSSRDAKSSGDSTSNKRKATVGTRSTRNNPNFNGGDDDDVIMQ 1015

  Fly  1042 --------------LYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFL--- 1089
                          ..|:::| :.:||||:|.::||:.:|...::|:|||....||::|.||
Mosquito  1016 KPENPTEWWMQMCPETELDNL-EHSGKLVVLMEILKECEAIGDKLLVFSQSLYSLDVIEHFLSLL 1079

  Fly  1090 -------EGEQ--------------YKYERIDGGITGTLRQEAIDRFN-APGAQQFVFLLSTRAG 1132
                   |.|:              ..|.|:||..:...|.:|...|| ....:..:||:|||||
Mosquito  1080 DENLQKDEDERDEQLSKYPGSWSLGLDYFRLDGSTSIDNRNDACKVFNDESNTRARLFLISTRAG 1144

  Fly  1133 GLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMML 1197
            ||||||..|:.|:|:|..|||.:|||:..|.:|.||:....||||:...::||::.:....|..:
Mosquito  1145 GLGINLVAANRVVIFDVSWNPSHDIQSIFRVYRFGQSKPCYIYRFIAMGTMEEKIYERQVTKQAI 1209

  Fly  1198 THLVVRPGMGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYD--------------DKAVAE 1248
            :..|:           .:|::|        ..:||:|.:|...|:              |:..||
Mosquito  1210 SKRVI-----------DEQQID--------RHYKENDLQELYRYEVETSEPRPTPNVPKDRLFAE 1255

  Fly  1249 LLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQH 1313
            ||.|.:..|             :|...:.:..|.:||||.     .|....|.|        |:.
Mosquito  1256 LLKRFDPLI-------------YKYHEHDSLLENKEEETL-----NEEERKAAW--------EEF 1294

  Fly  1314 QEDVGR----------SLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDED 1368
            :::..|          .||.|....:.||    |.|.:.||
Mosquito  1295 EQEKNRPPMPAYGTSGMLGIGGMGGRGVN----GPVTSSTT------------------------ 1331

  Fly  1369 GGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQD 1433
                 |..:|....|. ..|:.|:|.|.               ||    .:.:||::.|.|
Mosquito  1332 -----FGFRNDVLLKL-LHLKAREDNPT---------------FN----DATINAMIPYLM---- 1367

  Fly  1434 AFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLI 1498
                |.|.:.:|......:|:...|:              :...||.:.:::|:.:.....|
Mosquito  1368 ----QQLSQQMRDGELTMYKSLWELY--------------YKLEVPPQQMNQQYTMAYSNTM--- 1411

  Fly  1499 RKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAP 1563
                   :...|...|.:::  |.:|:... :|.:|.  :..|||.|.......|....||...|
Mosquito  1412 -------QPGGGGMVMGQMV--PQQPLMGQ-QQPMAG--SVVTGGPVVNMQYQMNPFPTATMPQP 1464

  Fly  1564 SPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEE 1601
            ..:.....|.....|.: ..:.|.|.:..:..:.|..|
Mosquito  1465 GISGMQTTGTAAGNDDD-VVEVTPANRGPIVIDPEVVE 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	15/69 (22%)
		TNG2	<282..422	CDD:227367	29/160 (18%)
		PHD1_CHD_II	380..422	CDD:277006	0/41 (0%)
		PHD2_CHD_II	440..482	CDD:277007	0/41 (0%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	10/69 (14%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	2/53 (4%)
		PLN03142	720..>1234	CDD:215601	162/681 (24%)
		DUF1087	<1292..1334	CDD:461922	10/51 (20%)
		CHDII_SANT-like	1380..1517	CDD:461920	22/136 (16%)
		CHDCT2	1757..1902	CDD:462358
LOC1273471	XP_312449.5	None