|
Fly 3 SEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKGEE 67
||||:.| .|.|:|..|..| :|:||.|.|..::...|..||:|.:|..:
Mouse 15 SEEEDMD----------------ALLNNSLPPPHP-ENEEDPDEDLSEAETPKLKKKKKPKKPRD 62
Fly 68 KGRKKKKRKKNE-----------SEEDSDFVQHDEEVEYPSTSK-----RGRKRKEEKQAAKEKE 116
....|.||:|.| |.|..:||:.:|||...|.|: .|:|:|::....|||:
Mouse 63 PKIPKSKRQKKERLLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKK 127
Fly 117 SASSGMPSVED---------------VCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKE 166
|.|......|: :...:.:.:::..:|||:.::||.||||...|||::..:
Mouse 128 SKSKRKEEEEEEDEDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAK 192
Fly 167 NPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQA---RSVTGDEPEEPRSSRSSRN 228
|||||..|::|::.||||||..:||.....|.:..:..:|..| ..||..|...|
Mouse 193 NPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPP-------- 249
Fly 229 EKPDDIYEEAVEEEEEEEEEEKKPRRKRSG--RGKKGRRPS-GKVPTLKIKLLG---KRKRDSSD 287
|..: |..:.:.:.:|.:....|||..| |....::|. .||..|||||.| ||||.||:
Mouse 250 --PPPV-EVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSE 311
Fly 288 EEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIG 352
|.||:.| :|..:|.::|.:.:....::...| |||.:|.
Mouse 312 -----------DDDLDVE---------SDFDDASINSYSVSDGSTSRSSRS-----RKKLRTA-- 349
Fly 353 NKFKKKNKLKKTKNFPEGEDG-EHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGK 416
|.|||.:.:.| ..|| |.:|||||||||||||||||||||||||:|||:|::::.||||
Mouse 350 -KKKKKGEEEVT-----AVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGK 408
Fly 417 WSCPHCEADG-------------------GAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHT 462
|||||||.:| |...||:||.|.||||||||||||||||:|||:||.
Mouse 409 WSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDPEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHI 473
Fly 463 FCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQ--------RSNDDGPSTSKGSKNSNS 519
.||||||..||:|:|.||||:||.|.||.:||:.|:|.| |..|..|:|.........
Mouse 474 HCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGR 538
Fly 520 RVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRH 584
..|::|:||..||||||.||.|:||::|..:|.|::|||.||:|||..:...||..:|.::
Mouse 539 PERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRK---- 599
Fly 585 KDKVGMKANDDAEV--LEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEE 647
|.|.:. :|||||:.|:||||:::.|::||...:.|...||:|||:||||:::||.
Mouse 600 --------NKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWES 656
Fly 648 EGDDIQGLRQAIDY------YQDLRAVCTSETTQSRSKKSKKGRKSKL-KVEDDEDRPVKHYTPP 705
|..:|| || |.:.|.:...| ..:..||.:|.|| |:| .|
Mouse 657 EDVEIQ------DYDLFKQSYWNHRELMRGE----EGRPGKKLKKVKLRKLE-----------RP 700
Fly 706 PEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFL 770
||.||.|...|||.||.:|:.||..|||||:||:||||:||.||.|||||||||||||:||..||
Mouse 701 PETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFL 765
Fly 771 YSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIR- 834
||||||||.:|||||:.||||::|||||||:||||.|.:||:|||||||:|||||.|||:.|||
Mouse 766 YSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRG 830
Fly 835 GSKVSRL-RTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA 898
|.|.||: :....||:|||||||||::|.|.|||||||.|:||||||||:|||||||:||.|::.
Mouse 831 GKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQ 895
Fly 899 YKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKT 963
:|||||||||||||||||||||||:.::|::|:.|..||||::||:|:|:||:|||||||||||.
Mouse 896 HKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKA 960
Fly 964 DVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLF 1028
||.||||||:|.|||||||.||||:||:|||:|:||||::.||...||:|::|||||||||||||
Mouse 961 DVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLF 1025
Fly 1029 PSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQ 1093
|.||.||.....|:|:.::|.:|:|||:||.||||.||...||||||||||||||:||||||.|.
Mouse 1026 PVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEG 1090
Fly 1094 YKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQ 1158
||||||||||||.:||||||||||||||||.||||||||||||||||||||||||||||||||||
Mouse 1091 YKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQ 1155
Fly 1159 AFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILR 1223
||||||||||..||||||||||.|||||:|||||:||||||||||||:|.|..:.:||||||||:
Mouse 1156 AFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILK 1220
Fly 1224 FGTEDLFKE-------DDKE----EAIHYDDKAVAELLDRTNRGIEEKE-SWANEYLSSFKVASY 1276
||||:|||: |:|| ..|||||||:..||||.....|:.| ...||||||||||.|
Mouse 1221 FGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQY 1285
Fly 1277 ATKE----EEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGG 1337
..:| ||||.|.|||||: |:.||.||.|||||||||.|||:.|:||||||:||||||.||
Mouse 1286 VVREEEMGEEEEVEREIIKQE-ESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDG- 1348
Fly 1338 VVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRD-DRPLPPLLA 1401
:::|.:|||:.|:..|:||..|:| ||:|||:::.|.|:..|:..|.| |:|||||||
Mouse 1349 ------SQEDRDWQDDQSDNQSDYSVASEE--GDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLA 1405
Fly 1402 RVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEP 1466
|||||||||||||||||:||||||||||||||||.:||||||||||||:.|||||||||||||||
Mouse 1406 RVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEP 1470
Fly 1467 GADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQ 1531
|||.|||||||||||||||||||||||||||||||||||||:||.:||||| ..|....|.
Mouse 1471 GADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPEL-----AEVEENKKM 1530
Fly 1532 DVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQ- 1595
......:|.| .:.:|.....|.| |:|.|.:|.|...:::|.||::.|..|| |||.
Mouse 1531 SQPGSPSPKT-----PTPSTPGDTQPNT---PAPVPPAEDGIKIEENSLKEEESTEGEK-EVKST 1586
Fly 1596 --EQEAEEDKKPGDVKQENPV-----EEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTE 1653
|...|..:.|.......|. |:.....:|.:.|.|.| |.|.||.|::| .:||
Mouse 1587 APEATVECAQPPAPAPATAPATATAPEDDKAPAEPPEGEEKVE--KAEVKERTEEP-----METE 1644
Fly 1654 EK---EKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGK 1715
.| |.|||::|..:..|.::.:|.::....:|..::...:..:|||. :..|
Mouse 1645 AKGTTEVEKVEEKSAVDLTPIVVEDKEEKKEEEEKKDVMLQNGETPKDL------------SDEK 1697
Fly 1716 GAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAA-VPGREYEIWHRRHDYWLLAGIVTHGYGR 1779
..::| |::||||||||||||||:||.|||:|| |..:.||||||||||||||||:.|||.|
Mouse 1698 QKKNS----KQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYAR 1758
Fly 1780 WQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSH 1844
|||||||.|:||:|||||.::.:|||||||||||||||||||||||||||||||||||:::||||
Mouse 1759 WQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSH 1823
Fly 1845 PAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARI 1909
|:|:||.|||||||||||||||||||:||||||||||||||.||||||||||:||:|||||:|||
Mouse 1824 PSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARI 1888
Fly 1910 PPVAQRLQMSERSILSRLAATA 1931
||||.|||||||:||||||..|
Mouse 1889 PPVAVRLQMSERNILSRLANRA 1910
| 
