Protein Alignment Mi-2 and chd2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_002933353.2
• Gene: chd2 / 100497210
• XenbaseID: XB-GENE-950755
• Length: 1809
• Species: Xenopus tropicalis
• Alignment Length: 2010
• Identity: 550/2010 - (27%)
• Similarity: 855/2010 - (42%)
• Gaps: 547/2010 - (27%)

  Fly    59 KRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMP 123
            :.:.:.|||.|........:.:.|:|:...:..|....|.|:...::..|..::.|...:
 Frog     3 RNEDKPGEEDGSAHSNASSHSASEESNHSVYGSESASQSESEHVTEQGSESNSSSESSES----- 62

  Fly   124 SVEDVCSAFSVCNVEIEYSEEELQSL--TTYKAFMHHVRPILQKENPKIAAPKLVMLVAAK--WR 184
                             :||.:.:|.  .|:.|...      .||.|   .||...|...|  |.
 Frog    63 -----------------HSESDCESTGSKTHDALAE------SKEKP---LPKKERLADVKKMWE 101

  Fly   185 EFCE------SNPHIQQEGGAAGSGGSAGQARSVTGD-EPEEP--RSSRSSRNEKPDDIYEEAVE 240
            |:.:      ||...|:.        |....::.:.| |.|.|  ||.||:| :|..:|..:..:
 Frog   102 EYPDVYGVRRSNRSRQEP--------SRFNIKAESSDSESESPRRRSMRSTR-KKEKNIVSDDED 157

  Fly   241 EEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIK--LLGKRKRDSSDEEQDASGASERDSDLE 303
            ||....|.:.:..:.||.|.:: :|...|..|.|:|  |.||:::.:|.||:|
 Frog   158 EEGSSAESDAEQTKFRSSRLQQ-KRKLAKSSTNKLKRSLRGKKRKQASSEEED------------ 209

  Fly   304 FERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKN-- 366
                  ..||..|:.|.|                                  |::.:.:..||
 Frog   210 ------DDDDDDDDDETP----------------------------------KRQTRRRAAKNVS 234

  Fly   367 FPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEE 431
            :.|.:|.|.:..|..|:.                                          |...|
 Frog   235 YKEDDDFETDSDDLIEMV------------------------------------------GEEAE 257

  Fly   432 EDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIIT 496
            |.:|.|:...:|                         ||:               ..||...|..
 Frog   258 ELEDSHETIEKV-------------------------LDS---------------RIGKKGAIGA 282

  Fly   497 WRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLD---VHHPLMIRSFQRK 558
            ......:.::|...|:.:..::.|.::|.|||...||.|..|..|..|.   |.....:.:|::|
 Frog   283 STTVYATEENGDPNSEFNPETDEREQQYLIKWKGWSYIHGTWESEDSLQQQKVKGLKKLENFKKK 347

  Fly   559 YDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRT 623
              .||..::...:...|..|...|:             |:..|      :..::.||:|||..:|
 Frog   348 --EEEIKQWLSKVSPEDVEYFSCQQ-------------ELASE------LNKQYQIVERVIAVKT 391

  Fly   624 ARDGS-----------------TMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVC-- 669
            ::..|                 ..||.||..|||.:.:||:.....:..:..||.:.     |
 Frog   392 SKSSSGHSDFPVHSRKTSSSNEPEYLCKWMGLPYSECSWEDGALVGKKFQHCIDSFN-----CRN 451

  Fly   670 TSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPT-TDLKKKYEDQPAFLEGTGMQLHP 733
            .|:||                       |||......::|. ..|||    ||:::.|.|::|..
 Frog   452 NSKTT-----------------------PVKDCKVLRQRPRFVTLKK----QPSYIGGEGLELRD 489

  Fly   734 YQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWERE 798
            ||:||:|||.:||.:....||||||||||||||::||..|:......||||:.||||||.:|:||
 Frog   490 YQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHLHLLYGPFLLVVPLSTLTSWQRE 554

  Fly   799 FELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAA 863
            ||:||||...:.||||..||..|||.|...::            :.:.|||.|||:||::..|.|
 Frog   555 FEVWAPDINVVVYIGDLGSRNTIREYEWVHQQ------------SKKMKFNALLTTYEILLKDKA 607

  Fly   864 CLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFN 928
            .|.||:||.|.||||||||::.|..::.|..:....:||:|||||||:|:||:.||:|:..:||.
 Frog   608 VLSSINWAFLGVDEAHRLKNDDSLLYKTLIEFKSNARLLITGTPLQNSLKELWSLLHFIMPEKFE 672

  Fly   929 DLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFIL 993
            ..:.|:.:... .::...:.||::|.|.:|||:|.||.|::|:|.|.|:|||:..|||::|::||
 Frog   673 CWEDFEDQHGK-GRDNGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMCVMQKQYYRWIL 736

  Fly   994 TKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLL 1058
            |:||:||:..:.|.:...:||:|:|||||||.:|.   ..|.|.....|..:.||.:::||||||
 Frog   737 TRNYKALSKGTRGSTSGFLNIVMELKKCCNHCFLI---KPEETEKESRLDSLQSLIRSSGKLVLL 798

  Fly  1059 SKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQF 1123
            .|:|.:|:.:.:||||||||.:|||||.::|..:.|.::|:||.|.|.||::|:|.|||.|::.|
 Frog   799 DKLLTRLRERGNRVLIFSQMVRMLDILAEYLAIKHYPFQRLDGSIKGELRKQALDHFNAEGSEDF 863

  Fly  1124 VFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVT 1188
            .|||||||||||||||:||||:|:||||||.||:||.:|||||||..:|.|||.|||.:|||.:.
 Frog   864 CFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTRGTVEEDII 928

  Fly  1189 QVAKRKMMLTHLVVR-----------PGMGGKGAN-FTKQELDDILRFGTEDLFKEDDKEEAIHY 1241
            :.||:||:|.|||::           ...|....| |.|.||..||:||..|||||.:.|| :..
 Frog   929 ERAKKKMVLDHLVIQRMDTTGRTVLDNNSGSSNCNPFNKDELAAILKFGAADLFKETEGEE-LEP 992

  Fly  1242 DDKAVAELL----DRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYW 1302
            .:..:.|:|    .|.|   |...|..:|.||.||||::||.|||.|   .::|::.|..|....
 Frog   993 QEMDIDEILRLAETREN---EPSSSATDELLSQFKVANFATMEEEPE---MVLKREQEWDDIIPE 1051

  Fly  1303 VKLLRHHYEQHQEDVG--------RSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNS 1359
            .:..:...|..|:::.        |||.|    :.|.|              ||. .|..|:..:
 Frog  1052 GQRKKVEEEARQKELQEIYMLPRIRSLNK----KPQAN--------------DSE-SDLESKQKA 1097

  Fly  1360 EYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAI 1424
            :.|:||:.|  .||.||....:|:.:.|..|:|             |:|  ||...:.:.|:.|.
 Frog  1098 QRSSGSESD--SDDSDDDKKPKRRGRPRSVRKD-------------NVE--GFTDAEIRRFIKAY 1145

  Fly  1425 MRYGMP-------PQDAFNSQWLVRDLRGKSERNFKAYVSL---FMRHLCEPGAD---------- 1469
            .::..|       .:||...:..|.||:...|....:..|.   |...|.|..||
 Frog  1146 KKFASPLERLECIARDAELVEKSVADLKRLGELLHNSCASAMQEFEEQLKENPADGKGPGKRRGP 1210

  Fly  1470 -------------------NAETFADGVPR--EGLSRQHVLTRIGVMSL-IRKKVQEFEHI---- 1508
                               :.|..:..:|.  |...:.:|::|:..... :...:::..|:
 Frog  1211 TIKISGVQVNVKAIIQHEEDFEVLSKSIPADPEEKKKFNVVSRVKAAHFDVEWAIEDDSHLLLGI 1275

  Fly  1509 --NGY------YSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSA-----TTSNSVTPATS 1560
              :||      .|.|||.|.     ...|..|.   |..|...::...|     .....:...|.
 Frog  1276 YEHGYGNWEHIKSDPELKLS-----EKILPVDT---EKKPQAKHLQTRADYLLKMLKKEMEKETG 1332

  Fly  1561 AAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVK---QEQEAEEDKKPGDVKQENPVEEAAGDTK 1622
            ||..|.....|...| |||.|.||:...:.|..:   ...|..|:|:.|..|..|..::...|.|
 Frog  1333 AAEEPKSKKRKPRAK-KDSGKTKDEHGNDISSPRHSDNNSEEGEEKEDGTEKNTNKKKQKKKDNK 1396

  Fly  1623 PSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKP----------------IPPTTV 1671
                  :.:..:|:.||..||   |::.| ::|||.|..:.||                ..|..:
 Frog  1397 ------ENKDKQTQKKEGDKD---KKKAK-DKKEKAKRGEAKPGGKNRKNQGPVHITAGSEPVPI 1451

  Fly  1672 IDDDDDDVMIVKEDGELEKPSASSPKD-----QKAVAAATSAATGATGKGAEDSLEVLKRKFMFN 1731
            .::::||         |::.:.|..|:     :||:....:|..|.:   .::.|| ..|..:..
 Frog  1452 GEEEEDD---------LDQETFSICKERMRPVKKALKQLDNADKGLS---VQEQLE-HTRTCLLK 1503

  Fly  1732 IADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPF 1796
            |.| ..:|...::.::|       ..::|  |.:.|:..
 Frog  1504 IGD-RISECLKMYSDQE-------HVKLW--RRNLWIFV-------------------------- 1532

  Fly  1797 KMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAE 1861
                  ..|.|...:.|.:.:|:..:....||:..:...::: :.|..|..|.::|
 Frog  1533 ------SKFTEFDARKLHKLYKMAHKKRSQEEEDHKKKDVSV-KKPFRPEQSGSSR--------- 1581

  Fly  1862 SHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSER 1921
             ..|:| :|...:.|...|:                           :||..|::...:|
 Frog  1582 -DPHVS-QSQGPHTPQKPVI---------------------------VPPHTQQVHSHQR 1612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	15/62 (24%)
		TNG2	<282..422	CDD:227367	17/141 (12%)
		PHD1_CHD_II	380..422	CDD:277006	1/41 (2%)
		PHD2_CHD_II	440..482	CDD:277007	3/41 (7%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	18/72 (25%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	18/70 (26%)
		PLN03142	720..>1234	CDD:215601	258/525 (49%)
		DUF1087	<1292..1334	CDD:461922	10/49 (20%)
		CHDII_SANT-like	1380..1517	CDD:461920	33/190 (17%)
		CHDCT2	1757..1902	CDD:462358	18/144 (13%)
chd2	XP_002933353.2	CD1_tandem_CHD1-2_like	264..346	CDD:349313	21/121 (17%)
		CD2_tandem_CHD1-2_like	379..450	CDD:349308	18/75 (24%)
		DEXHc_CHD2	467..703	CDD:350812	113/252 (45%)
		PLN03142	471..>1005	CDD:215601	265/554 (48%)
		CDH1_2_SANT_HL1	1132..1220	CDD:465731	17/87 (20%)
		DUF4208	1466..1548	CDD:464035	18/127 (14%)