Protein Alignment Mi-2 and chd7

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_002936158.2
• Gene: chd7 / 100379668
• XenbaseID: XB-GENE-877230
• Length: 2969
• Species: Xenopus tropicalis
• Alignment Length: 2213
• Identity: 555/2213 - (25%)
• Similarity: 844/2213 - (38%)
• Gaps: 754/2213 - (34%)

  Fly   148 SLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSG--GSAGQAR 210
            ||...:.|:    |.:|.:.|:            |.|:  :.|.||..:....|.|  |..|:..
 Frog   572 SLMNTEDFL----PSMQSQTPQ------------KKRK--KKNNHIATDKTVGGFGLEGFPGENS 618

  Fly   211 SVTGD-EPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLK 274
            .:..| .|:..:..:....::|.:..|...::|.:|.:..|:|:..:..:.||.:..:.|....|
 Frog   619 DLLIDGAPDGKKKKKPKVKKEPKEPKEPKAKKEPKEPKAPKQPKPPKEPKEKKVKTTTPKPKASK 683

  Fly   275 IKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSAD-EKEAPVSSKADNSAPAAQDDGS 338
                      .:..:.||.|::::.   :..::..:..:..| :|..|.||.   ..|..::|.|
 Frog   684 ----------KTSNKSDAEGSAQKK---KVNKVKPEGVEPLDLDKTPPPSSP---PPPPEEEDDS 732

  Fly   339 GAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLV 403
            |   |:|          ::.::..|.|.:.|.
 Frog   733 G---VQK----------RRSSRQVKRKRYTED--------------------------------- 751

  Fly   404 CLEPEL-DEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNP 467
             ||.:: ||.|:        :|||.                          || ||       |.
 Frog   752 -LEFKISDEEPD--------DADGR--------------------------DS-PS-------NT 773

  Fly   468 PLDTIPDG-DWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNM 531
            ....:.|| |...|         ..|||::.|..::..:.|...         .:.|:::|:.|.
 Frog   774 SQSELQDGLDAEGP---------VVEKIMSCRLTKKQLESGEEV---------EIEEFYVKYKNY 820

  Fly   532 SYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTR-YKRIQRHKDKVGMKANDD 595
            ||.||.|....:|                            |.|.| .::|:|.|.|.|.  |..
 Frog   821 SYLHCHWATLEEL----------------------------EKDKRIQQKIKRFKAKQGQ--NKF 855

  Fly   596 AEVLEERFYKNGVKPEWLIVQRVINHRTARD--GSTM--YLVKWRELPYDKSTWEEEGDDIQGLR 656
            ...:|:..:    .|:::.|.|:::..|:.|  |..:  |||||..|||:.||||        |:
 Frog   856 LSEIEDDLF----NPDYVEVDRILDVATSTDENGEPVCHYLVKWCSLPYEDSTWE--------LK 908

  Fly   657 QAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQP 721
            |.:|                   ::|.....||:..:.|...|       |:|..|..||.|...
 Frog   909 QDLD-------------------QAKIEEFEKLQSREPETERV-------ERPPADDWKKSESSR 947

  Fly   722 AFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVA 786
            .:....  .|..||:||:|||.::|....:.|||||||||||||::||||.:|.:| ..|||||.
 Frog   948 EYKNNN--SLREYQLEGVNWLLFNWYNKRNCILADEMGLGKTIQSITFLYEIYLKG-IHGPFLVI 1009

  Fly   787 VPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEE---GAIRGSKVSRLRTTQYKF 848
            .||||:.||||||..|. :...:.|.|.:.||..|:..|:.|::   ..|:|:         |||
 Frog  1010 APLSTIPNWEREFRTWT-ELNVVVYHGSQASRKTIQLYEMYFKDPQGKIIKGA---------YKF 1064

  Fly   849 NVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLE 913
            :.::|::|:|..|...|.:|.|..:|:|||||||:...|....|....:.:|:|||||||||.:|
 Frog  1065 HAIITTFEMILTDCPELRNIHWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVE 1129

  Fly   914 ELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVR 978
            |||.|||||..|:|.....|..||.|:..||||::|..:|.|.||||||.||.||:..|.|.|:.
 Frog  1130 ELFSLLNFLEPDRFPSESNFMQEFGDLKTEEQVQKLQGILKPMMLRRLKEDVEKNLAPKEETIIE 1194

  Fly   979 VELSAMQKKFYKFILTKNYEALNSKSGGGSC---SLINIMMDLKKCCNHPYLFPSAAE------- 1033
            |||:.:|||:|:.||.||:..|:...|||..   :|:|.||:|:||||||||...|.|
 Frog  1195 VELTNIQKKYYRAILEKNFAFLSKGGGGGHANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFR 1259

  Fly  1034 EATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYER 1098
            |........:::.::|:|||||||:.|:|.:|||..|||||||||.:.||||||:|...:|.|||
 Frog  1260 ETHNCDPSDFQLQAMTQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYER 1324

  Fly  1099 IDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRA 1163
            |||.:.|.|||.|||||:.|.:.:|||||.||||||||||..|||.||:||||||.||:||.:|.
 Frog  1325 IDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARC 1389

  Fly  1164 HRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGA-----NFTKQELDDILR 1223
            |||||:..|.|||.:||||.|..:...|..|:.|...|::...|...|     ..:|:|::|:||
 Frog  1390 HRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDNATNGVQQLSKKEIEDLLR 1454

  Fly  1224 FGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIE-EKESWANEYLSSFKVAS------------ 1275
            .|...... |:::|...:.::.:.::|.|....|. |.|...:.:..:..|||
 Frog  1455 KGAYGALM-DEEDEGSKFCEEDIDQILSRRTHTITIESEGKGSTFAKASFVASGNRTDISLDDPN 1518

  Fly  1276 ----YATKEE-----------------------------EEEEETEIIKQDAENSD-PAY----- 1301
                :|.|.|                             :|:|..|....::::.| |:.
 Frog  1519 FWQKWAKKAELDLDVLNGRNTLVIDTPRVRKQTRLFSAVKEDELMEFSDLESDSEDKPSIKPRRP 1583

  Fly  1302 --------------------------WVKLLRH-------------------------HYEQHQE 1315
                                      |..:|.|                         ||...:.
 Frog  1584 QDKSLGYARSECFRVEKNLLVYGWGRWTDILSHGRFKRQLSEQDVETICRTILVYCLNHYRGDEN 1648

  Fly  1316 DVG--------------RSL-------------GKGKRVRKQ----------------------- 1330
            ..|              |:|             .|||:|:.|
 Frog  1649 IKGFIWDLITPTEDGQTRALVNHSGLSAPVPRGRKGKKVKSQNSQPVLKHADWLQSCNPDTLFQE 1713

  Fly  1331 --------------------VNYTDGGVV---------AADTTRDD------------SNWQDNG 1354
                                :.|....|:         .||::..|            ::|.||.
 Frog  1714 DSYKKHLKHHCNKVLLRVRMLYYLRQEVIGDQADKILEGADSSEVDVWIPEPFHAEVPTDWWDNE 1778

  Fly  1355 SE--------------YNS----------------------EYSAGSD--EDGGD---------- 1371
            ::              |||                      ....|:|  .||||
 Frog  1779 ADKSLLIGVFKHGYEKYNSIRADPALCFLERAGMPDAKAIAAEQRGTDMLADGGDGGDFDREDED 1843

  Fly  1372 -----------DDFDD------------------------------------------------Q 1377
                       ||.|:                                                |
 Frog  1844 PEYKPARLPFKDDIDEFANSPLEDKEEEMEPTGKSGEGSTELGHLYWPNTSSLTTRLRRLITAYQ 1908

  Fly  1378 NGAERK-----AKRRLERRDDRPLPPLLARVGGNIEVL-----GFNARQRKSFLNAIMRYGMPPQ 1432
            ...:|:     |:.:::||..||...:.|.......::     .:..|:...|...:..:|:...
 Frog  1909 RSYKRQQMRQDAQMKIDRRRRRPREEVRALEAEREAIITEKRQKWTRREEADFYRVVSTFGVIFD 1973

  Fly  1433 DA-----FNSQWLVRDLRGKSERNFKAYVSLFM---RHLCEPGADNAETFAD------GVPREGL 1483
            :|     :|.......|..||:.:.:.|.|.|:   |.:|..|....|...|      .:..|..
 Frog  1974 NAKQKFDWNQFRAYARLDKKSDESLEKYFSCFVAMCRRVCHMGTKPDEDICDLSMLIEPITEERA 2038

  Fly  1484 SRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEP-----------------VRSALKQ 1531
            ||  .|.||.::..||::|.....:|..       ||.|:|                 :..|.|.
 Frog  2039 SR--TLYRIELLRKIREQVLNHPQLNER-------LKLCQPSIDLPEWWDCGKHDRDLLVGAAKH 2094

  Fly  1532 DVAA-------------LEAPPTGGNVDKSATTSN------------SVTPATSAAPSPAPASEK 1571
            .|:.             |||..:......|:..||            ...|...:.|:|   .||
 Frog  2095 GVSRTDYHILNDPELSFLEAHRSFAQNKGSSQPSNLPILIPPGPGYSDTPPIMPSTPNP---DEK 2156

  Fly  1572 GE-DKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVK-TEVAK 1634
            |. :::..:||.:|....|::|||:||  .||.....:|||:.:|..     |...|:| ||...
 Frog  2157 GSGNEEAITEKVEDPVIKEEAEVKEEQ--AEDTAEKSIKQESDLEAI-----PVKDEIKMTEETP 2214

  Fly  1635 TEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQ 1699
            ..||      .:.|:...|:.||...|||..       :....:|.|..:|...::.|
 Frog  2215 VGPK------SISEKGSEEDDEKLDYDDKSE-------ESSQAEVGIASQDKNFDEES------- 2259

  Fly  1700 KAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTL---------WLNEE------- 1748
               .|:.|.|...|..|             |.:.||..:.||.|         |..:.
 Frog  2260 ---NASLSTARDETRDG-------------FYLEDGEQSGLHMLRERTFSFSFWPKDRVMINRLD 2308

  Fly  1749 ---KAAVPGREYEIW--HRRHDY---WLLAG-------------------IVTHG-YGRWQDIQN 1785
               :|.:.|:    |  :||..:   .||.|                   :|..| |...:||..
 Frog  2309 NICEAVLKGK----WPVNRRQMFDFPGLLPGYTPTAVDSPLQKRSFAELSMVAQGSYSGSEDISA 2369

  Fly  1786 DIRFAIINEPFKMDVG-------KGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPS 1843
            ..:   :::...:.:.       :...:|::.:..|:|..|:|..    .|||.:..  .|::..
 Frog  2370 SPQ---VSQETALSLSVPRQRRRRRRKVEVEAERAAKRRNLMEMV----AQLRGSQM--GAENGQ 2425

  Fly  1844 HPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSD-MKSDVSRLPATLA 1907
            ...:.|:....|......|...|:.:.|             ||.....:|| .|:.:.||.|.|:
 Frog  2426 EKVVDLSNASREATSSTSSFPSLTSQFL-------------LNNSSTPVSDAFKTQMERLQAGLS 2477

  Fly  1908 RIP 1910
            ..|
 Frog  2478 CTP 2480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	8/42 (19%)
		TNG2	<282..422	CDD:227367	22/141 (16%)
		PHD1_CHD_II	380..422	CDD:277006	5/42 (12%)
		PHD2_CHD_II	440..482	CDD:277007	9/42 (21%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	14/69 (20%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	21/57 (37%)
		PLN03142	720..>1234	CDD:215601	252/531 (47%)
		DUF1087	<1292..1334	CDD:461922	15/168 (9%)
		CHDII_SANT-like	1380..1517	CDD:461920	33/160 (21%)
		CHDCT2	1757..1902	CDD:462358	30/177 (17%)
chd7	XP_002936158.2	PAT1	<30..>183	CDD:401645
		Med15	110..>545	CDD:312941
		CD1_tandem_CHD5-9_like	783..848	CDD:349315	21/110 (19%)
		CD2_tandem_CHD5-9_like	866..923	CDD:349310	23/83 (28%)
		PLN03142	955..>1482	CDD:215601	255/538 (47%)
		BRK	2550..2591	CDD:462196
		BRK	2628..2671	CDD:462196