Protein Alignment Mi-2 and chd8

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_012812626.1
• Gene: chd8 / 100192376
• XenbaseID: XB-GENE-966847
• Length: 2335
• Species: Xenopus tropicalis
• Alignment Length: 2117
• Identity: 554/2117 - (26%)
• Similarity: 833/2117 - (39%)
• Gaps: 619/2117 - (29%)

  Fly   112 AKEKESASSGMPSVEDVCSAFSVCN-------VEIEYSEEELQSLTTYKAFMHHVRPILQKENPK 169
            |...:..:.|: ||..|.:|..|.|       |:......|.:.|.:            ||:..|
 Frog   348 AGSSQGTAQGL-SVVKVLNASEVANLTASQTVVKTSTGGGESRKLDS------------QKKQEK 399

  Fly   170 IAAPKLVMLVAAKWREFCESN-PHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDD 233
              |.::|....|:.|...|.| |.:..|          .:..||   .||:...||..|.:|
 Frog   400 --ANRIVAEAIARARARGEQNIPRVLNE----------DELPSV---NPEDDDGSRRKRKKK--- 446

  Fly   234 IYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASER 298
                  :.|..:..:::|| :|..|.|....|..||..|:...:..||||:.|.:..||
 Frog   447 ------KGETSDRSKDEKP-KKVKGSGSLRSRSKGKPSTITPIVGKKRKRNPSSDNSDA------ 498

  Fly   299 DSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKK 363
                  |.|                  |..::||..:|.     |:|          ::.|:..|
 Frog   499 ------EIM------------------ASQASPAEDEDS-----VQK----------RRSNRQVK 524

  Fly   364 TKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGA 428
            .|.:.|                                                     :.|...
 Frog   525 RKKYTE-----------------------------------------------------DLDIKI 536

  Fly   429 AEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPL------ 487
            .::|||:|      |...|         |.......|..|: .:||.:      :.|.:
 Frog   537 TDDEDDEE------VDVTG---------PVKTEPVLLPEPM-PLPDSE------AVPSMQFFVEN 579

  Fly   488 -----TGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVH 547
                 ....:||::.|.|::....|...         .|.|||:|:.|.||.||||....||
 Frog   580 PSEEDAAIVDKILSMRLAKKELPTGEYV---------EVEEYFVKYKNYSYLHCEWATIEQL--- 632

  Fly   548 HPLMIRSFQRKYDMEEPPKFEESLDEADTR-YKRIQRHKDKVGMKAN---DDAEVLEERFYKNGV 608
                                     |.|.| :::::|.|.|:....:   :|    ||.|
 Frog   633 -------------------------ERDKRIHQKLKRFKTKMTQMQHFLQED----EESF----- 663

  Fly   609 KPEWLIVQRVI--NHRTARDGS---TMYLVKWRELPYDKSTWE--EEGDDIQGLRQAIDYYQDLR 666
            .|:::.|.|::  :|.|.:|..   ..|||||..|||:.||||  |:.||     ..|:.::.:
 Frog   664 NPDYVEVDRILDESHSTDKDNGEPVVYYLVKWCSLPYEDSTWELKEDVDD-----GKIEEFKRI- 722

  Fly   667 AVCTSETTQSRSKK-SKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQ 730
                 |..|...|: ::....|..|:|                    |.::|::        |.|
 Frog   723 -----EARQPNLKRVARPAATSWKKLE--------------------LSREYQN--------GNQ 754

  Fly   731 LHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNW 795
            |..||:||:|||.::|....:.|||||||||||||::|||..:|..| .||||||..||||:.||
 Frog   755 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSITFLQEVYNVG-IRGPFLVIAPLSTITNW 818

  Fly   796 EREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISM 860
            ||||..|. ....|.|.|...||.:|::.|:..::     || .||....|||:.|:|::|::..
 Frog   819 EREFGSWT-QMNTIVYHGSLASRQMIQQYEMYCKD-----SK-GRLIPGAYKFDALITTFEMVLS 876

  Fly   861 DAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRD 925
            |...|..|:|..:::|||||||:...|....|....:.:|:|||||||||.:||||.||:||...
 Frog   877 DCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPT 941

  Fly   926 KFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK 990
            :|:....|..:|.|:..||||::|..:|.|.||||||.||.||:..|.|.|:.|||:.:|||:|:
 Frog   942 QFSSEAEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYR 1006

  Fly   991 FILTKNYEAL-NSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAE-------EATTAAGGLYEINS 1047
            .||.||:..| ...|...:.:|:|.||:|:||||||||...|.|       |||......:.:.:
 Frog  1007 AILEKNFSFLTKGASQSNTPNLLNTMMELRKCCNHPYLITGAEEKIISEFREATPVVPPDFHVQA 1071

  Fly  1048 LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAI 1112
            :.:::|||||:.|:|.:|:|..|:|||||||.:.||||||:|...:|.||||||.:.|.:||.||
 Frog  1072 MVRSSGKLVLIDKLLPKLRAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNMRQAAI 1136

  Fly  1113 DRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRF 1177
            |||:.|.:.:|||||.||||||||||..|||.||:||||||.||:||.:|.|||||:..|.|||.
 Frog  1137 DRFSRPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKIYRL 1201

  Fly  1178 VTRNSVEERVTQVAKRKMMLTHLVVRPGMG------GKGANFTKQELDDILRFGTEDLFKEDDKE 1236
            :||||.|..:...|..|:.|...|::...|      |....|||:|::|:||.|......::|.|
 Frog  1202 ITRNSYEREMFDKASLKLGLDKAVLQSMSGRDNHLSGPIQQFTKKEIEDLLRKGAYAAIMDEDDE 1266

  Fly  1237 EAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAY 1301
            .:...::.....||.||.....|.|...    |:|..||:...|.         :.|....||.:
 Frog  1267 GSKFCEEDIDQILLRRTTTITIESEGKG----STFSKASFVASEN---------RTDISLDDPNF 1318

  Fly  1302 WVKLLRHHYEQHQEDVGRSLGKGK--------RVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYN 1358
            |.|..:      :.|:...|...|        |:|||             ||..:|..|:..|:
 Frog  1319 WQKWAK------KADLDLDLLSSKNTLVIDTPRIRKQ-------------TRHFTNKDDDMVEF- 1363

  Fly  1359 SEYSAGSDEDGGDDD------FDDQNGAERKAKRRLERRDDRPLPPLLARVGGN-IEVL------ 1410
                  ||.:..|||      .|.::|..|....|:|:.       ||....|. .::|
 Frog  1364 ------SDLESDDDDRPKARRQDRKHGYGRTDCFRVEKH-------LLVYGWGRWRDILTHGRFK 1415

  Fly  1411 -GFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAET- 1473
             |.|.|..:....||:.|.:              |..:.:.|.|:    |:..|..| |:|.:|
 Frog  1416 RGMNERDVEKICRAILVYCL--------------LHYRGDENIKS----FIWDLITP-AENGKTK 1461

  Fly  1474 -------FADGVPR--------------------------------EGLSR--QH----VLTRIG 1493
                   .:..|||                                ||..:  :|    ||.|:.
 Frog  1462 QLQNHSGLSIPVPRGRKGKKVKSQSSFDIHKADWIHKYNPDTLFQDEGYKKHLKHQCNKVLLRVR 1526

  Fly  1494 VMSLIRKKV---QEFEHINGYYS------MPEL---------------------ILKPCEPVRSA 1528
            ::..:|::|   |..:.::|..:      .|::                     :.|......:.
 Frog  1527 MLYFLRQEVIGNQAMKVLSGVEARQIDIWFPQVDQVEVPSRWWDREADKSLLIGVFKHGYEKYNT 1591

  Fly  1529 LKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKD-------KDSEKEKDK- 1585
            ::.|.|.......|| .|:.|..:.......|..|.........||.:       ||.|.|.|.
 Frog  1592 MRADPALCFLEKVGG-PDEQAIAAEHHAQDFSELPDGGDFDRDIEDPEYKPLHAQKDPEDEIDSL 1655

  Fly  1586 ------------------------------------TSAEKSEVKQEQEAEEDKKPGDVKQENPV 1614
                                                .:|.:...|:||...|.::.||.:::..
 Frog  1656 MMDEEISVVDGEEATAMPSGMLWPPGSALTARLRRLITAYQRSYKREQLKLEAEERGDKRRKRC- 1719

  Fly  1615 EEAAGDTKPSDAEVKTEVAKTEPKEETKDPE------------VKEEPKTEEKEKEKVDDKKPIP 1667
             |||...|        |:|:.|.::.....|            |:.:|.|:      :.|.:...
 Frog  1720 -EAAFKLK--------EIARREKQQRWTRREACDFFRVLSSFGVEYDPDTQ------LYDWQRFR 1769

  Fly  1668 PTTVIDDDDDD---------VMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEV 1723
            ....:|...|:         |.:.::...|...:...|.|........|....:......|.|..
 Frog  1770 GLARLDKKTDESLLKYFHGFVAMCRQVCRLPPAAGDEPPDPSLFIEPISEERASRALFRLDLLRR 1834

  Fly  1724 LKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHR--RHDYWLLAGIVTHGYGRWQ-DIQN 1785
            ::.:.:          .|.|.:.......|..|...|..  |||..||.|...:|..|.. .|..
 Frog  1835 VREQVL----------CHPLLIPRLSLCRPDPELPEWWESGRHDNELLQGAARYGLSRTDLTILQ 1889

  Fly  1786 DIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLR-----RAAYLNLAQDPSHP 1845
            |..|              :||..:..:.        |:..|....|     .|..:...:.|||.
 Frog  1890 DHAF--------------SFLRCQISYF--------QSRGISGHSRPSTPTTAPSVPTERQPSHL 1932

  Fly  1846 AMSLNARFA-------EVECLAESHQHLSKESLAGN-----KPANAVLHKVLNQLEELLSDMKSD 1898
            | ||::..:       ...|.:.||...|::|...:     ||...:.|..|...|..||
 Frog  1933 A-SLSSSVSCSPAPRRSSSCSSSSHSSNSEDSSDESNGVKVKPNAGLSHARLYDEESRLS----- 1991

  Fly  1899 VSRLPATLARIPPVAQRLQM-------SERSILSRL-----AATAGNASNAAQLMAQFPAGFQGT 1951
            ::..||.|.....:...|:.       .:|.::.|:     |...|..|:..:| :..|:....:
 Frog  1992 LTASPADLTTEDSIQTALETPHSTDWPKDRVLICRIEQVCSAVLTGKWSSPRRL-SDPPSDSPDS 2055

  Fly  1952 TLPAFTSGPAGNFANFRP-----QFSVPGQLSNNSGV 1983
            ..|........:|...||     :|::  |:.:..|:
 Frog  2056 LPPTPEQQSPAHFTQIRPAPDPKEFTI--QIKSEEGL 2090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	11/53 (21%)
		TNG2	<282..422	CDD:227367	17/139 (12%)
		PHD1_CHD_II	380..422	CDD:277006	0/41 (0%)
		PHD2_CHD_II	440..482	CDD:277007	7/41 (17%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	19/80 (24%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	22/60 (37%)
		PLN03142	720..>1234	CDD:215601	248/527 (47%)
		DUF1087	<1292..1334	CDD:461922	12/49 (24%)
		CHDII_SANT-like	1380..1517	CDD:461920	36/199 (18%)
		CHDCT2	1757..1902	CDD:462358	36/164 (22%)
chd8	XP_012812626.1	Med15	35..>363	CDD:312941	4/15 (27%)
		CD1_tandem_CHD5-9_like	582..647	CDD:349315	23/101 (23%)
		CD2_tandem_CHD5-9_like	665..723	CDD:349310	22/68 (32%)
		PLN03142	754..>1357	CDD:215601	275/642 (43%)
		DEXHc_CHD8	755..976	CDD:350818	105/228 (46%)
		BRK	2122..2165	CDD:462196