Protein Alignment Rab8 and RAB28

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_001017979.1
• Gene: RAB28 / 9364
• HGNCID: 9768
• Length: 221
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 64/214 - (29%)
• Similarity: 104/214 - (48%)
• Gaps: 10/214 - (4%)

  Fly     3 KTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIEL-DNKKIKLQIWDTAG 66
            ::.|...|::::||...|||.:...|:::.|...:..|||:||.:|.|.| .|..:.|||||..|
Human     7 ESQDRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQIWDIGG 71

  Fly    67 QERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNW---IRNIEENASADVEKMLLGNKCELTDK 128
            |.....:...|..||.|::||||||..:||||:::|   ::.:.|.:.......|:|||.:|...
Human    72 QTIGGKMLDKYIYGAQGVLLVYDITNYQSFENLEDWYTVVKKVSEESETQPLVALVGNKIDLEHM 136

  Fly   129 RQVSKERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDI------KAKTEKRMEANNPPKGGH 187
            |.:..|:..:...|.|......|||...:|...|..:|::|      ||:.|:...........:
Human   137 RTIKPEKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVNY 201

  Fly   188 QLKPMDSRTKDSWLSRCSL 206
            ..:||.........|.|::
Human   202 NQEPMSRTVNPPRSSMCAV 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	58/175 (33%)
RAB28	NP_001017979.1	Rab28	13..221	CDD:206694	63/208 (30%)
		Switch I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753, ECO:0000269|PubMed:19026641, ECO:0007744|PDB:3E5H	35..49		4/13 (31%)
		Switch II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753, ECO:0000269|PubMed:19026641, ECO:0007744|PDB:3E5H	68..85		4/16 (25%)