Protein Alignment Rab8 and RAB11B

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_004209.2
• Gene: RAB11B / 9230
• HGNCID: 9761
• Length: 218
• Species: Homo sapiens
• Alignment Length: 187
• Identity: 85/187 - (45%)
• Similarity: 126/187 - (67%)
• Gaps: 3/187 - (1%)

  Fly     5 YDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQER 69
            ||||||::|||||||||:.:|.||:.:.||....||||::|..|:|::|.|.||.||||||||||
Human     8 YDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQER 72

  Fly    70 FRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKE 134
            :|.||:||||||:|.:|||||.:..::||::.|::.:.::|.:::..||:|||.:|...|.|..:
Human    73 YRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTD 137

  Fly   135 RGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPPKGGHQLKP 191
            .....|.:..:.|:||||..|.||||||..:.::|.....::..|:   :..|...|
Human   138 EARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIAD---RAAHDESP 191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	81/165 (49%)
RAB11B	NP_004209.2	Rab11_like	9..173	CDD:206660	80/163 (49%)
		Switch 1. /evidence=ECO:0000305|PubMed:16545962, ECO:0007744|PDB:2F9L, ECO:0007744|PDB:2F9M	36..47		6/10 (60%)
		Switch 2. /evidence=ECO:0000305|PubMed:16545962, ECO:0007744|PDB:2F9L, ECO:0007744|PDB:2F9M	67..86		15/18 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..218		2/8 (25%)