DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rab8 and RAB7A

DIOPT Version :10

Sequence 1:NP_524172.1 Gene:Rab8 / 40168 FlyBaseID:FBgn0262518 Length:207 Species:Drosophila melanogaster
Sequence 2:NP_004628.4 Gene:RAB7A / 7879 HGNCID:9788 Length:207 Species:Homo sapiens


Alignment Length:401 Identity:69/401 - (17%)
Similarity:124/401 - (30%) Gaps:149/401 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEIALMNLLLLLLQI---------QDNWPSVLFAMAGGVGLSIG--NLATQYSLAFVGLSVTEVT 54
            ::|.|.|....:..|         .:::|:::..:...:.:::.  |||...|..|....|..:.
Human  1080 IKITLFNYFSTMFSIIIYTIVQFYGEDFPALIHILIKTILMALPSYNLAMSISKYFDDYEVKRLC 1144

  Fly    55 AASITVV--------VGTTVNYFLDNGLNRADILFSGVGCFMVAVCLGSAVHSSNSADI------ 105
            |.....:        :...|..|.::|:.:..|..:.:|...:.:.|.....||:..:.      
Human  1145 AREFRSIYMDCSEPFIQNNVYGFGEHGIGKFLITLATMGLVFLLLLLSLESVSSSLKNFVFRNVL 1209

  Fly   106 -----KAKLGKLSGDCETVTPEECQRLFGVEEEEEEEKEMENVKEGSAAFLIALENKRAIKVLGK 165
                 |.:.|:                .||..:..:|.|.|:::          :.||.:     
Human  1210 FYFYNKIRKGR----------------HGVHSKSTKEDEDEDIR----------KEKRKV----- 1243

  Fly   166 SMVVGLGITFFAGLSFSLFSPLFNLATNDQWHTLKQGVPKLIVYTAFFYFSLSCFVIAVALNISF 230
                              |:.|..|          |..|.::......||  .|.|:....|||.
Human  1244 ------------------FTLLLRL----------QNTPLVLNEVTKIYF--KCPVVKAVKNISL 1278

  Fly   231 LYKPVLDSPRSSFREYLSDWNGRGWALAAGLLCG---FGNGLQFMGGQAA-----------GYA- 280
            :.       |.|....|...||.|......:|.|   ..:|:.|:.|.:.           ||. 
Human  1279 VV-------RKSECFGLLGLNGAGKTTTFKMLTGEETITSGIAFIDGNSVTKNPRKIRSRIGYCP 1336

  Fly   281 ASDAV-------QALPLVSTFWGI----------------------------YLFGEYRRSSTRT 310
            .|::|       ::|.:.:..||:                            |..|..||.|| .
Human  1337 QSESVLNHMTGRESLIMYARLWGVPEQDINEYVEAFLHSVHLEPIADQIIYTYSAGSKRRLST-A 1400

  Fly   311 YALLVGMLVMF 321
            .||:....|:|
Human  1401 IALMGKSSVVF 1411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rab8NP_524172.1 Rab8_Rab10_Rab13_like 6..172 CDD:206659 27/195 (14%)
RAB7ANP_004628.4 Rab7 9..179 CDD:206655
Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN 28..41
Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN 67..82
Blue background indicates that the domain is not in the aligned region.

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