Protein Alignment Rab8 and RAB25

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_065120.2
• Gene: RAB25 / 57111
• HGNCID: 18238
• Length: 213
• Species: Homo sapiens
• Alignment Length: 174
• Identity: 77/174 - (44%)
• Similarity: 120/174 - (68%)
• Gaps: 0/174 - (0%)

  Fly     5 YDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQER 69
            |:::||::|||:||||||.:|.||:.:.|:....:|||::|..||:.|....:|.|||||||.||
Human     9 YNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLER 73

  Fly    70 FRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKE 134
            :|.||:||||||:|.:||:|:|:.:::..::.|::.:.::|.|.:..||:|||.:|:..|:|..|
Human    74 YRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTE 138

  Fly   135 RGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRME 178
            .....|...|:.|:||||..|.|||.||.|:..:|.||..|:.:
Human   139 EARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQ 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	73/165 (44%)
RAB25	NP_065120.2	Rab11_like	11..174	CDD:206660	72/162 (44%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	35..49		4/13 (31%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	67..84		12/16 (75%)