Protein Alignment Rab8 and RAB40A

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_543155.2
• Gene: RAB40A / 142684
• HGNCID: 18283
• Length: 277
• Species: Homo sapiens
• Alignment Length: 203
• Identity: 78/203 - (38%)
• Similarity: 113/203 - (55%)
• Gaps: 24/203 - (11%)

  Fly     3 KTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQ 67
            :.||:|.|.||:||..|||:.||....:.|..:.:....|||:|..||.||.:::||::|||:||
Human     9 QAYDFLLKFLLVGDRDVGKSEILESLQDGAAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQ 73

  Fly    68 ERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVS 132
            .||.||..:|.|||.|::|||||....|||.:..||:.|||:|.. |.|:|:||:..|..||||.
Human    74 GRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPG-VPKILVGNRLHLAFKRQVP 137

  Fly   133 KERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPPKGGHQLKPMDSRTK 197
            :|:.:..|...|:.|.|.|...:.|:.|:|..||..:..:              |::
Human   138 REQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLR--------------HRM-------- 180

  Fly   198 DSWLSRCS 205
             :||.|.|
Human   181 -NWLGRPS 187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	72/165 (44%)
RAB40A	NP_543155.2	P-loop containing Nucleoside Triphosphate Hydrolases	9..277	CDD:476819	78/203 (38%)
		Switch-I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	41..49		0/7 (0%)
		Switch-II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	72..88		9/15 (60%)
		SOCS_Rab40	187..228	CDD:239711	1/1 (100%)