Protein Alignment Rab8 and RAB10

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_057215.3
• Gene: RAB10 / 10890
• HGNCID: 9759
• Length: 200
• Species: Homo sapiens
• Alignment Length: 205
• Identity: 141/205 - (68%)
• Similarity: 162/205 - (79%)
• Gaps: 12/205 - (5%)

  Fly     3 KTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQ 67
            ||||.||||||||||||||||:|||||:|||||||||||||||||:|:||..|||||||||||||
Human     4 KTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQ 68

  Fly    68 ERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVS 132
            |||.||||:|||||||||||||||..||||||..|:|||:|:|:.|||:|||||||::.|||.|.
Human    69 ERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVP 133

  Fly   133 KERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKT---EKRMEANNPPKGGHQLKPMDS 194
            |.:|||:|.|:||:|.||||||:||:|:||||||.||..||   |...|..:...||
Human   134 KGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDISSGG-------- 190

  Fly   195 RTKDSWLSRC 204
             ....|.|:|
Human   191 -GVTGWKSKC 199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	129/165 (78%)
RAB10	NP_057215.3	Rab8_Rab10_Rab13_like	7..173	CDD:206659	129/165 (78%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	32..46		13/13 (100%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	64..81		14/16 (88%)