Protein Alignment Papss and PAPSS1

DIOPT Version :10

• Sequence 1: NP_730460.1
• Gene: Papss / 40167
• FlyBaseID: FBgn0020389
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_005434.4
• Gene: PAPSS1 / 9061
• HGNCID: 8603
• Length: 624
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 391/617 - (63%)
• Similarity: 480/617 - (77%)
• Gaps: 17/617 - (2%)

  Fly    44 LQVATNVTEQKHHVTRETRGKNLGLCRGFRGCTVWLTGLSGAGKTSIAFELEAYLVSRGIPAYGL 108
            :|.|||||.|.|||:|..||:.:|...||||||||||||||||||:::..||.|||..|||.|.|
Human    22 MQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTL 86

  Fly   109 DGDNIRTGLNKNLGFTPADREENIRRVGEVAKLFADSGVVAICSFVSPFADDREMARKIHKDAGL 173
            ||||||.||||||||:|.|||||:||:.||||||||:|:|.|.||:||:..||..||:||:.|.|
Human    87 DGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASL 151

  Fly   174 KFYEIFVDTPLDVCETRDVKGLYKKAREGVIKGFTGITQEYERPQMPELVVNTHGYTVRESTQKL 238
            .|:|:|||.||.|||.|||||||||||.|.|||||||..|||:|:.||||:.|....|.:..|::
Human   152 PFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQV 216

  Fly   239 VTLLEQEGIIPRSLRDVDL---LPELYPSESIATEALRHEAESLQAIEISTVELQWVQVLAEGWA 300
            |.||::..|:|     ||.   :.|||..|: .....:.:||:|.|::|:.|::|||||||||||
Human   217 VELLQERDIVP-----VDASYEVKELYVPEN-KLHLAKTDAETLPALKINKVDMQWVQVLAEGWA 275

  Fly   301 YPLRGFMREDEYLQTLHFNTLQSGMDGSYRENHSVPIVLSATQADKDRLDGCSSLTLKYQGKAVA 365
            .||.|||||.||||.|||:.|   :||.. .|.||||||:||..||:|||||::..|.|:|:.||
Human   276 TPLNGFMREREYLQCLHFDCL---LDGGV-INLSVPIVLTATHEDKERLDGCTAFALMYEGRRVA 336

  Fly   366 ILRRPEFYFQRKEERLARQFGTSNPNHPYSKQVYESGDYLVGGDLAVIERIRWEDGLDQYRLTPN 430
            |||.|||:..|||||.|||:||:..||||.|.|.|.||:|:||||.|::|:.|.||||||||||.
Human   337 ILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDGLDQYRLTPT 401

  Fly   431 ELRRRFKELNADAIFAFQLRNPIHNGHALLMQDTRRQLLERGFKQPVLLLHPLGGWTKDDDVPLD 495
            ||:::||::||||:||||||||:|||||||||||.:||||||:::|||||||||||||||||||.
Human   402 ELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLM 466

  Fly   496 VRMKQHQAVLDAGVLRREDTVLAIFPSPMMYAGPTEVQWHAKARMNAGANFYIVGRDPAGMPHPA 560
            .|||||.|||:.|||..|.||:||||||||||||||||||.:|||.||||||||||||||||||
Human   467 WRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHP- 530

  Fly   561 KETYPDGNLYDATHGARVLKMAQGLDSMEILPFRVAAYDKSASRMAFFEPKRKDEFEFISGTKMR 625
             ||..|  ||:.:|||:||.||.||.::||:|||||||:|...||.:::.:..::|||||||:||
Human   531 -ETGKD--LYEPSHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMR 592

  Fly   626 TLAKTGASPPDGFMEPEAWRILATYYQNLPQS 657
            .||:.|..||:|||.|:||.:|..||::|.::
Human   593 KLAREGQKPPEGFMAPKAWTVLTEYYKSLEKA 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Papss	NP_730460.1	CysC	55..249	CDD:440295	124/193 (64%)
		ATPS	279..650	CDD:173895	248/370 (67%)
PAPSS1	NP_005434.4	Adenylyl-sulfate kinase. /evidence=ECO:0000305|PubMed:15755455, ECO:0000305|PubMed:17276460, ECO:0000305|PubMed:17540769	1..225		130/202 (64%)
		CysC	33..227	CDD:440295	124/193 (64%)
		Sulfate adenylyltransferase. /evidence=ECO:0000305|PubMed:15755455	234..624		257/398 (65%)
		ATPS	254..617	CDD:173895	248/370 (67%)