Protein Alignment Deaf1 and Deaf1

DIOPT Version :10

• Sequence 1: NP_524169.1
• Gene: Deaf1 / 40164
• FlyBaseID: FBgn0013799
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_058570.1
• Gene: Deaf1 / 54006
• MGIID: 1858496
• Length: 566
• Species: Mus musculus
• Alignment Length: 605
• Identity: 165/605 - (27%)
• Similarity: 254/605 - (41%)
• Gaps: 139/605 - (22%)

  Fly    18 AALAEDVVKEEVILESSSHHHHHHHHQLDTKVRMVTSSSNDNSGSGGASGGT-------SGAGGG 75
            ||.|.:...||.:|............:.:.:.|.||:.:...:.||....||       ..|...
Mouse    29 AAAAAESEAEEPVLSRDEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAA 93

  Fly    76 NGGGGVVSVPVSLPIGSMITGTTFNVITPDQLPPHFKPMLCVDNNGYLSGSTVS------MGNDL 134
            .....|.:|.|: .:||    :..||.|..           |.|...:||..:|      :|:.|
Mouse    94 AAFAEVTTVTVA-NVGS----SADNVFTTS-----------VANAASISGHVLSGRTALQIGDSL 142

  Fly   135 KT-----IVIQQQQTQPGGGGGGANNAGTNTTATNTIGLNHDGS----GSNNSHDSLATLEHAAG 190
            .|     ||:.                 |:.:...|.||....:    |..:....||.
Mouse   143 NTEKATLIVVH-----------------TDGSIVETTGLKGPAAPLTPGPQSPPTPLAP------ 184

  Fly   191 GASGVGGGGGGTGGGSSGWSENPSTQHNEVFQIRCKTTCAELYRSKLGSGGRGRCVKYKDKWHTP 255
                    |...||....|  :||...:|: .:||:.....||:|:|||||||||:|..:.|::|
Mouse   185 --------GQEKGGTKYNW--DPSVYDSEL-PVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSP 238

  Fly   256 SEFEHVCGRGSSKDWKRSIKYGGKSLQSLIDEGTLTPHATNCSCTVCCDDEAGESASGPVRLFTP 320
            :|||.:.||.|||||||||:|.|:.||.||.:|.|.|||.:|:|..||||   .:.|||||||.|
Mouse   239 TEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDD---MTLSGPVRLFVP 300

  Fly   321 YKRRKRNQTDLDMESGPKRKRNTHH-------SNNNNSNTNNNNTSGSGA-----NNCVDVTAAV 373
            |||||:..   ::.:.|.:|.:..:       :....:.|.:...:.|||     .:.|:.||.:
Mouse   301 YKRRKKEN---ELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVI 362

  Fly   374 AAATASVVDENNMF----LSEENI-----TSKDEP-WAALNDS----------LDTSTELVDQSQ 418
            :.:.|    :.::|    :.|..:     ....|| :....||          |.||...:..:.
Mouse   363 SESPA----QGDVFAGATVQEAGVQPPCRVGHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTS 423

  Fly   419 MGNTYERETFVVNINDGSSIAVLDTSQ--SMKNIEHVYCTMVKATNDFKRMLNDMKQSFERRIEV 481
            :.......:........:.::.|:.|:  |...:|.:..:::......|.:....||:
Mouse   424 LPALAVPPSTPTKAVSPTVVSGLEMSEHRSWLYLEEMVNSLLNTAQQLKTLFEQAKQA------- 481

  Fly   482 LQKERDAAVSAMRVQVHADIDDPNISGSLHGNEIISAKKCANCNREALAECSLCRKTPYCSEFCQ 546
             ...|:|||:..|:||..:..:               :.|.||.|||::||:.|.|..|||.|||
Mouse   482 -SSCREAAVTQARMQVDTERKE---------------QSCVNCGREAMSECTGCHKVNYCSTFCQ 530

  Fly   547 RKDWNAHQVECTRNPQTTTQ 566
            ||||..||..|.::...|.|
Mouse   531 RKDWKDHQHVCGQSASVTVQ 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Deaf1	NP_524169.1	SAND	219..291	CDD:128554	39/71 (55%)
		zf-MYND	521..557	CDD:460312	22/35 (63%)
Deaf1	NP_058570.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..62		3/28 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..191		5/31 (16%)
		SAND	202..274	CDD:128554	27/71 (38%)
		Nuclear localization signal. /evidence=ECO:0000255	300..306		3/5 (60%)
		Interaction with LMO4	404..479		12/92 (13%)
		zf-MYND	505..541	CDD:460312	9/35 (26%)