DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha1 and KPNA4

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_002259.1	Gene:	KPNA4 / 3840	HGNCID:	6397	Length:	521	Species:	Homo sapiens

Alignment Length:	544	Identity:	251/544 - (46%)
Similarity:	343/544 - (63%)	Gaps:	42/544 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAADM 71
            :.:||...|...|||:|.||.::||||||::.|.|||||..|....      :|:.|.:.:..:.
Human    13 KNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICE------DSDIDGDYRVQNT 71

  Fly    72 HMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQK 136
            .:                       |.::|...|..:..||.|.|..|||||.|.||||:::|:.
Human    72 SL-----------------------EAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKS 113

  Fly   137 GIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAV 201
            ||:|..|..|....|.:|||||||.|||||||||:||:.|:::.|||:|:.||.|||.:|.||||
Human   114 GILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAV 178

  Fly   202 WALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISHG 266
            ||||||.||.|.|||:::..|:::|||..:|.|..||.:||..|.:.||||.|.||.....|...
Human   179 WALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEI 243

  Fly   267 LPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAV 331
            ||.|..|:.:||.::|.||.||:.||:|..|::||.|||:|:...||.||.|.:..|.|||||||
Human   244 LPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAV 308

  Fly   332 GNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQL 396
            ||||||.|:||||:|..:||:....||....|.|.||:.|.:|||.|||::|:||:|:||:.|.:
Human   309 GNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMI 373

  Fly   397 MVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALENI 461
            :.::...:|.|:|||||||:|.|.||..:|:.||:|...:||.|:.|||.|:.:|||.|:.|.||
Human   374 IHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNI 438

  Fly   462 LK-AGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNE--EEDSRVAPV 523
            || |.::.:|..|    .|||||||:|||.||.|||.|||..::.||:|:|.::  :||..:.|.
Human   439 LKMAEDEAETIGN----LIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPE 499

  Fly   524 A---GTQQFEFDPD-NMPSTGFNF 543
            |   ||  |.|:.. |:|:.||.|
Human   500 AIQGGT--FGFNSSANVPTEGFQF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	250/542 (46%)
		IBB	3..116	CDD:280005	30/108 (28%)
		ARM	131..252	CDD:237987	65/120 (54%)
		armadillo repeat	133..165	CDD:293788	16/31 (52%)
		armadillo repeat	173..209	CDD:293788	22/35 (63%)
		armadillo repeat	215..250	CDD:293788	13/34 (38%)
		ARM	264..378	CDD:237987	58/113 (51%)
		armadillo repeat	267..292	CDD:293788	11/24 (46%)
		armadillo repeat	300..336	CDD:293788	22/35 (63%)
		armadillo repeat	342..376	CDD:293788	14/33 (42%)
		ARM	356..461	CDD:237987	49/104 (47%)
		armadillo repeat	384..421	CDD:293788	17/36 (47%)
		armadillo repeat	427..461	CDD:293788	15/33 (45%)
		Arm_3	473..517	CDD:292804	23/45 (51%)
KPNA4	NP_002259.1	SRP1	11..513	CDD:227396	246/534 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	43..52		5/8 (63%)
		ARM 1, truncated	66..106		14/62 (23%)
		armadillo repeat	73..98	CDD:293788	8/47 (17%)
		ARM 2	107..149		24/41 (59%)
		armadillo repeat	109..142	CDD:293788	16/32 (50%)
		NLS binding site (major). /evidence=ECO:0000250	137..229		52/91 (57%)
		armadillo repeat	150..186	CDD:293788	22/35 (63%)
		armadillo repeat	192..227	CDD:293788	13/34 (38%)
		ARM 4	195..233		16/37 (43%)
		ARM 5	234..278		17/43 (40%)
		armadillo repeat	244..269	CDD:293788	11/24 (46%)
		ARM 6	279..318		24/38 (63%)
		armadillo repeat	279..311	CDD:293788	18/31 (58%)
		NLS binding site (minor). /evidence=ECO:0000250	306..394		46/87 (53%)
		armadillo repeat	319..355	CDD:293788	16/35 (46%)
		ARM 8	361..400		18/38 (47%)
		armadillo repeat	361..395	CDD:293788	15/33 (45%)
		ARM 9	401..443		20/41 (49%)
		armadillo repeat	404..438	CDD:293788	15/33 (45%)
		ARM 10, atypical	447..485		23/41 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2158
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.860