DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha1 and ankar

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001035135.2	Gene:	ankar / 368636	ZFINID:	ZDB-GENE-030616-533	Length:	1400	Species:	Danio rerio

Alignment Length:	506	Identity:	110/506 - (21%)
Similarity:	211/506 - (41%)	Gaps:	67/506 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QQLFKRRNVVLE---PATSSTSAGVESNTDNEQQAADMHMADSSTGG--QNEEAAGSGA------ 90
            |.|.::...:||   ||...:|..:.|.|....:|.|..:   |||.  :.|::.|:..
Zfish   619 QVLCRKDPTLLEMKTPAEYGSSPLLLSATSGSVEALDFLL---STGANWREEDSKGNNCVHLAAL 680

  Fly    91 --QPSVINEEMIQMLFSGR-------ENEQLEATQKFRKLLS------RDPNPPIEEVIQKGIVP 140
              ...|: :.:||:...|.       |..|:|..::..|.|.      .:.....|:::..|.||
Zfish   681 YFHTDVL-KHLIQLNLDGLPVWKILVEMLQIEDFKRMEKTLGCLEALCVNTESFSEDILDAGGVP 744

  Fly   141 QFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAVWALG 205
            ..|:.| .|....:|..|...|.::.. .||..:.::..|||||.|.|||....::..:....|.
Zfish   745 VLVSLL-CSDRQVVQCMATAVLCHMTE-NSQVCEELVHHGAVPILIKLLSVHQPELDSRCAVILA 807

  Fly   206 NIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISH--GLP 268
            ::|..|...:..:...|.:..::::|: ||...::.|.|..:..|| .:||....| ::|  |:|
Zfish   808 DLAAHSKQHQSLIADLGGVALVVNLLT-SDLQDVLVNGVRCIRTLC-VRSPHNQTA-VAHAGGVP 869

  Fly   269 ILARLLKYTDADVL-SDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAVG 332
            .|.::|. .|:|.| .:.|.|:..||.|..:....:.:||....||:.|.|.:.:|...|..|:.
Zfish   870 HLIQILA-VDSDTLQEEACLALAELSRGHRENQALICEAGAVGALVQALRHRKISVKVKAASALE 933

  Fly   333 NIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQLM 397
            ::.:.:....|..|..:|...:..||......::::....:..:|..:..|.:.:.....:..::
Zfish   934 SLASHNSAIQQCFLRQSAPKYLLQLLTVFQLDVREQGAIALWALAGQSLNQQKLMAEQMGYSVIL 998

  Fly   398 VIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMC-----------DFLTVVDS--- 448
            .::.:...|.:.....|:...:......|..:..:.| |||:.           ..|:|:::
Zfish   999 DLLLSPSDKIQYVGCRAVIALSRDSRIHQNGFCRENG-VPPLVRLLRGSRTGQKTLLSVIEALGC 1062

  Fly   449 DIVQVALNALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDI 499
            ..:.|||...:|..|...:.|..|.             .:|.|:||::::|
Zfish  1063 LCIGVALTTNKNSQKTVYREQAIPT-------------LLELLKAHKSQEI 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	110/506 (22%)
		IBB	3..116	CDD:280005	23/98 (23%)
		ARM	131..252	CDD:237987	31/120 (26%)
		armadillo repeat	133..165	CDD:293788	9/31 (29%)
		armadillo repeat	173..209	CDD:293788	10/35 (29%)
		armadillo repeat	215..250	CDD:293788	6/34 (18%)
		ARM	264..378	CDD:237987	27/116 (23%)
		armadillo repeat	267..292	CDD:293788	8/25 (32%)
		armadillo repeat	300..336	CDD:293788	9/35 (26%)
		armadillo repeat	342..376	CDD:293788	5/33 (15%)
		ARM	356..461	CDD:237987	16/118 (14%)
		armadillo repeat	384..421	CDD:293788	2/36 (6%)
		armadillo repeat	427..461	CDD:293788	9/47 (19%)
		Arm_3	473..517	CDD:292804	5/27 (19%)
ankar	NP_001035135.2	ANK	489..621	CDD:238125	1/1 (100%)
		Ank_2	489..599	CDD:289560
		ANK repeat	520..550	CDD:293786
		ANK	569..691	CDD:238125	17/75 (23%)
		ANK repeat	569..599	CDD:293786
		Ank_2	574..663	CDD:289560	14/46 (30%)
		ANK repeat	601..630	CDD:293786	2/10 (20%)
		ANK repeat	632..662	CDD:293786	9/32 (28%)
		Ank_4	638..691	CDD:290365	11/56 (20%)
		armadillo repeat	702..726	CDD:293788	5/23 (22%)
		ARM	735..852	CDD:237987	30/119 (25%)
		armadillo repeat	736..768	CDD:293788	9/32 (28%)
		armadillo repeat	784..809	CDD:293788	8/24 (33%)
		ARM	819..937	CDD:237987	33/121 (27%)
		armadillo repeat	826..851	CDD:293788	5/25 (20%)
		armadillo repeat	868..893	CDD:293788	8/25 (32%)
		armadillo repeat	901..937	CDD:293788	9/35 (26%)
		armadillo repeat	943..977	CDD:293788	5/33 (15%)
		ARM	987..1109	CDD:237987	21/128 (16%)
		HEAT repeat	990..1019	CDD:293787	2/28 (7%)
		armadillo repeat	1025..1071	CDD:293788	10/46 (22%)
		armadillo repeat	1077..1108	CDD:293788	8/37 (22%)
		armadillo repeat	1165..1202	CDD:293788
		armadillo repeat	1210..1243	CDD:293788
		ARM	1212..1310	CDD:237987
		armadillo repeat	1249..1283	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910