Protein Alignment Kap-alpha1 and Kpna6

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001015029.2
• Gene: Kpna6 / 362607
• RGDID: 1306570
• Length: 541
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 342/544 - (62%)
• Similarity: 407/544 - (74%)
• Gaps: 37/544 - (6%)

  Fly     9 YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAA-DMH 72
            |||.||:..||||||||.||||||.||||||||||||.|               .||:.|. |..
  Rat    22 YKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVEL---------------INEEAAMFDSL 71

  Fly    73 MAD---SSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVI 134
            :.|   |||.|:           |||..||::||||...:.||..|||||||||::|:|||:|||
  Rat    72 LMDSYVSSTTGE-----------SVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 125

  Fly   135 Q-KGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQE 198
            . .|:|.:||.||:.|.|.||||||||.|||||||||||||:|||||||||||:||:|..:||||
  Rat   126 NTPGVVDRFVEFLKRSENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQE 190

  Fly   199 QAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKI 263
            |||||||||||||.:|||::|...||.|||.:|:.|.|:||.|||||.||||||||:||.:|||:
  Rat   191 QAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV 255

  Fly   264 SHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAAL 328
            |..||:|:|||..:|:|:|:|.|||:.|||||||:|||||||:||||||||||:|....|::.||
  Rat   256 SPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPAL 320

  Fly   329 RAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIF 393
            |||||||||||.||||||..:||.|:.|||.|:.|:|:||:|||||||.||||.||||:|:||||
  Rat   321 RAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIF 385

  Fly   394 PQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNAL 458
            |.|:.|:|.|||:||||||||||||||.||.|||.|||.:||:.|:||.|||:||.|||||||.|
  Rat   386 PVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGL 450

  Fly   459 ENILKAGEKFQTRP----NPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDSR 519
            ||||:.||:...|.    |||...|||..||||||:||:|||::||.|:|.:||.|||.|::||.
  Rat   451 ENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSS 515

  Fly   520 VAPVAG--TQQFEFDPDNMPSTGF 541
            :||...  .|||.|.....|..||
  Rat   516 LAPQVDETQQQFIFQQPEAPMEGF 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	342/544 (63%)
		armadillo repeat	133..165	CDD:293788	20/32 (63%)
		armadillo repeat	173..209	CDD:293788	29/35 (83%)
		armadillo repeat	215..250	CDD:293788	20/34 (59%)
		armadillo repeat	267..292	CDD:293788	13/24 (54%)
		armadillo repeat	300..336	CDD:293788	26/35 (74%)
		armadillo repeat	342..376	CDD:293788	21/33 (64%)
		armadillo repeat	384..421	CDD:293788	28/36 (78%)
		armadillo repeat	427..461	CDD:293788	23/33 (70%)
Kpna6	NP_001015029.2	SRP1	41..530	CDD:227396	324/514 (63%)
		armadillo repeat	131..157	CDD:293788	17/25 (68%)
		armadillo repeat	165..201	CDD:293788	29/35 (83%)
		armadillo repeat	207..242	CDD:293788	20/34 (59%)
		armadillo repeat	259..284	CDD:293788	13/24 (54%)
		armadillo repeat	292..328	CDD:293788	26/35 (74%)
		armadillo repeat	334..368	CDD:293788	21/33 (64%)
		armadillo repeat	376..412	CDD:293788	27/35 (77%)
		armadillo repeat	419..453	CDD:293788	23/33 (70%)