DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha1 and acan

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_017948155.2	Gene:	acan / 100491091	XenbaseID:	XB-GENE-921494	Length:	1683	Species:	Xenopus tropicalis

Alignment Length:	234	Identity:	57/234 - (24%)
Similarity:	85/234 - (36%)	Gaps:	74/234 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ATSSTS--AGVESNTDN-----EQQAADMHMADSSTGGQNEEAAGSGAQPSVINEEMI-----QM 102
            |||...  :|::|..|:     .....|..:.:..|.|.:.:.||.|  ||||.|  |     :.
Frog  1184 ATSGVEYVSGLQSGFDDLSGVPTVSHIDFTLKEPPTQGPDTQEAGEG--PSVILE--ISGISGES 1244

  Fly   103 LFSGRENEQLEA----TQKFRK--LLSRDPNPPIEEVIQKGIVPQ---FVTF---LRNSANATLQ 155
            |.||.....||:    |..|.:  |::.|    ..|.|.|..|.|   .|||   :..||:..:.
Frog  1245 LPSGTHEGSLESSGIYTSGFSQVTLVTDD----TVEAITKPAVSQELGGVTFAYPIETSASGDIS 1305

  Fly   156 FEAAWTLTNIASGTSQQTKVVIEAGAVP-----IFI----------DLLSSPHDDVQEQAVWA-- 203
            .||:.|     ..||.:.:..:|....|     .|:          ::..||.:..||..:..
Frog  1306 TEASAT-----HETSGKQETSLEGSTEPSSGQLTFLPPEISETSESEITHSPEEAQQETELVTSV 1365

  Fly   204 -LGNIAGD------SP-------------MCRDHLLGSG 222
             ||.:..:      ||             .|.|...|:|
Frog  1366 ELGEVTDEPTIEAASPSSLIATESEGIIGSCADQPCGAG 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	57/234 (24%)
		IBB	3..116	CDD:280005	23/81 (28%)
		ARM	131..252	CDD:237987	30/135 (22%)
		armadillo repeat	133..165	CDD:293788	12/37 (32%)
		armadillo repeat	173..209	CDD:293788	9/53 (17%)
		armadillo repeat	215..250	CDD:293788	3/8 (38%)
		ARM	264..378	CDD:237987
		armadillo repeat	267..292	CDD:293788
		armadillo repeat	300..336	CDD:293788
		armadillo repeat	342..376	CDD:293788
		ARM	356..461	CDD:237987
		armadillo repeat	384..421	CDD:293788
		armadillo repeat	427..461	CDD:293788
		Arm_3	473..517	CDD:292804
acan	XP_017948155.2	Ig	33..155	CDD:416386
		Ig strand A	33..36	CDD:409353
		Ig strand A'	39..41	CDD:409353
		Ig strand B	45..53	CDD:409353
		Ig strand C	72..78	CDD:409353
		Ig strand C'	83..86	CDD:409353
		Ig strand D	104..109	CDD:409353
		Ig strand E	115..121	CDD:409353
		Ig strand F	129..136	CDD:409353
		Ig strand G	146..155	CDD:409353
		Link_domain_CSPGs_modules_1_3	153..247	CDD:239594
		Link_domain_CSPGs_modules_2_4	254..350	CDD:239597
		Link_domain_CSPGs_modules_1_3	483..577	CDD:239594
		Link_domain_CSPGs_modules_2_4	584..679	CDD:239597
		PRK15319	<891..>1398	CDD:185219	54/226 (24%)
		EGF	1396..1424	CDD:394967	4/9 (44%)
		EGF_CA	1429..1465	CDD:238011
		CLECT_CSPGs	1471..1594	CDD:153058
		CCP	1598..1655	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000