DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha1 and Armc3

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_017455917.1	Gene:	Armc3 / 100361506	RGDID:	2319961	Length:	868	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	100/484 - (20%)
Similarity:	193/484 - (39%)	Gaps:	85/484 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 EEMIQMLFSGRENE----QLEATQKFRKLLSRDPNPPIEEVIQKGIVPQFVTFLRNSANATLQFE 157
            |.:.:....|.||:    :|.|.:...|||:.:     ::::::..:..|.....||....|..|
  Rat    47 EAIYKFALKGEENKATLLELGAVEPLTKLLTHE-----DKIVRRNAMMIFGILASNSDVKKLLRE 106

  Fly   158 AAWTLTNIASGTSQQTKVVIE--------------AGAVPIF--------IDLLSSPHDDVQEQA 200
            .. .::::.:..|.:.:|||.              .|.|.||        |.|||||..||::.:
  Rat   107 LE-VMSSVIAQLSPEEEVVIHEFASLCLANMSVEYTGKVQIFEHGGLEPLIRLLSSPDPDVKKNS 170

  Fly   201 VWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISH 265
            :..:.|:..|. .||..|.....:.|:|.:|.:...|..:. |:.||..:...|...... |.:.
  Rat   171 IECIYNLVQDF-QCRTTLQELNAIPPILELLKSEYPIIQLL-ALKTLGVITCDKEARTTL-KDNQ 232

  Fly   266 GLPILARLLKYTDADVLSDTCWAI--GYLSDGPNDKIQAVIDAGVCRRLVELLLHP-----QQNV 323
            ||..|.::|:..:.:.|.....|:  ..|.|  .|.:..:..:|..::::....:.     |:|.
  Rat   233 GLDHLTKILETKELNDLHVEALAVIANCLED--MDTMVLMQQSGSLKKVLSFAENSTIPDIQKNA 295

  Fly   324 STAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALI 388
            :.|..:|     ..|.:..:|........|:..||.|.::..|..:...||  |.......:...
  Rat   296 AKAITKA-----AYDPENRKVFHEQEVEKCLVTLLGSDSDGTKIAASQAIS--AMCENLSCKEFF 353

  Fly   389 NANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFL---------- 443
            |....||::.::::...:.|:.||.|:.|.|:| :....:...:...:.|:.:.|
  Rat   354 NTQGIPQIVQLLKSDNEEVREAAALALANLTTS-SPANANAAAEADAIDPLINILSSKRDGAVAN 417

  Fly   444 --TVVDSDIVQVALNAL---ENILKA--GEKFQTR---PNPYAITI-------------EECGGL 485
              ||:.:..:|..|.|:   ..|::|  |....|.   .:..|:|:             :.||||
  Rat   418 AATVLTNMAIQEPLRAIIQNHEIMRALLGPLHSTNTVVQSTAALTVAATACDVESRNELKNCGGL 482

  Fly   486 DKIEYLQAHENRDIYHKSFYIIEQYFGNE 514
            :.:..|...:|.::...:.:.|....|:|
  Rat   483 EPLIELLHSKNDEVRRHASWAIMVCAGDE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	100/484 (21%)
		IBB	3..116	CDD:280005	6/22 (27%)
		ARM	131..252	CDD:237987	33/142 (23%)
		armadillo repeat	133..165	CDD:293788	5/31 (16%)
		armadillo repeat	173..209	CDD:293788	16/57 (28%)
		armadillo repeat	215..250	CDD:293788	9/34 (26%)
		ARM	264..378	CDD:237987	23/120 (19%)
		armadillo repeat	267..292	CDD:293788	5/26 (19%)
		armadillo repeat	300..336	CDD:293788	5/40 (13%)
		armadillo repeat	342..376	CDD:293788	8/33 (24%)
		ARM	356..461	CDD:237987	24/119 (20%)
		armadillo repeat	384..421	CDD:293788	9/36 (25%)
		armadillo repeat	427..461	CDD:293788	7/48 (15%)
		Arm_3	473..517	CDD:292804	11/55 (20%)
Armc3	XP_017455917.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910