Protein Alignment SREBP and SREBF2

DIOPT Version :10

• Sequence 1: NP_524166.2
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Alignment Length: 1125
• Identity: 350/1125 - (31%)
• Similarity: 525/1125 - (46%)
• Gaps: 132/1125 - (11%)

  Fly    26 FEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQSVDQQPQSVEQQPHVKSEHSSP 90
            |.|..|...:..|.:.::...:..|.....:| :||...|      .|||:..||..|....:..
Human   100 FSPSAASPQAPTLQVKVSPTSVPTTPRATPIL-QPRPQPQ------PQPQTQLQQQTVMITPTFS 157

  Fly    91 VHIKEELHQQQQQSPLLVYKPDPLIATSYNCPQQQPTGLLKAA--QPTA---TIHHMDAQRMPPN 150
            ...:..:.||.     |:|:.   .|||:...|.|...|:.::  ||..   .:..:.|||:...
Human   158 TTPQTRIIQQP-----LIYQN---AATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQ 214

  Fly   151 TAVYPPSLGSSFVYQSMSPPTSPVESANQNVNVMQPVAATPAPASAPLPQ-QSYP---QPFITYN 211
            ||        :...|:::|.|            :|.|||         || |..|   ||.|...
Human   215 TA--------NGTLQTLAPAT------------VQTVAA---------PQVQQVPVLVQPQIIKT 250

  Fly   212 SKAGMTS-----DEAMYFLLQPTV-ASPTPSPPVA-PPPTSTGSRASKVRVAPLAPSPAAMEVQG 269
            ....:|:     ...|..:..|.: |..||....| ..||..||..:.:...|:      |..|.
Human   251 DSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPV------MMGQE 309

  Fly   270 KVPINRVQPKVKEV-------KRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSI 327
            ||||.:|...||::       :|:.||.||:|||:||||||.|||:||:|..||::||.||||:|
Human   310 KVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAI 374

  Fly   328 DKIRDLQRQNHDLKAELQRLQRELMARDGSKVKDLLQLGTR-PGRASKKRRESSQTFTTDAGLTP 391
            |.|:.||:.||.|:.|...|:   :|...:|:...:.||:. ......|..:.:|....   ::|
Human   375 DYIKYLQQVNHKLRQENMVLK---LANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLL---MSP 433

  Fly   392 PRSDE-SDPSLSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFM 455
            |.||. |....||...| |.|.||.        ...:...:||...|.:: ||...||:.||:..
Human   434 PASDSGSQAGFSPYSID-SEPGSPL--------LDDAKVKDEPDSPPVAL-GMVDRSRILLCVLT 488

  Fly   456 FAILAVNPFKTFLQRGHYDSNDDLGDMSGQRRILSYDVEGEGFAVWQQSS-WIWLLNFTLMLGCL 519
            |..|:.||..:.||.|....:|........|.:||::....|:..|...: .:||:|..::|...
Human   489 FLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVF 553

  Fly   520 VKLLVYGDPQL---DAQTDAYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQ 581
            |||||:|:|.:   ...:..:.:||::||...::|..:.|......||.:.|.:||.|||:....
Human   554 VKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACS 618

  Fly   582 TTWQFLRFLFHRL----W-LGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGS 641
            .:|..:|:...:|    | |.:|...|.....:.|....:|..|||:.||.::||:||.:||...
Human   619 LSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKLP 683

  Fly   642 RGD-MNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQEC 705
            .|. .:.:.|||.|.|:||.|...:.|...:.||:..|:.:|......|..| |.|::|||:..|
Human   684 AGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFL-ASYFLSRAQSLC 747

  Fly   706 GLTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLL 770
            | ...:.....|||.....|.::.....::.   .|..::..:...|||.||.|.|.:.:.::||
Human   748 G-PEHSAVPDSLRWLCHPLGQKFFMERSWSV---KSAAKESLYCAQRNPADPIAQVHQAFCKNLL 808

  Fly   771 FKAIQCLV--GAGHKSGGLPTSSVS-GEAEQLQQQQHSGT----IVSNVLKYTSLLKDTLWADED 828
            .:||:.||  .|..|:|.....|.. ..|.:..:..||..    ::|..|..:|:||..|..|..
Human   809 ERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDII 873

  Fly   829 ERDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAVLRAKMILL 893
            .|     ||...:..|:.||.|:|......:.:::::|..|:.  ....|.||:....||....|
Human   874 CR-----WWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEV--TESPLVKAIFHACRAMHASL 931

  Fly   894 KNNGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETRTALWELEH 958
            ....:....|...     |:.:|..|...|.|:..|....:..:.||||||.||..|||||:.:.
Human   932 PGKADGQQSSFCH-----CERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQA 991

  Fly   959 MNMEDDG-FYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLMAGASPCPTQQLLDR 1022
            ...:..| .|...|..|..||.||.|||.:..:...|..:::|:||..||||||||..|.|||:.
Human   992 SASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEH 1056

  Fly  1023 SLRSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGERAGMLAEAAKTLEK 1087
            |||.|...|:.. |..|...     |:||||:|:.:||::||.:.|||||:||.:|||||:||||
Human  1057 SLRRRTTQSTKH-GEVDAWP-----GQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEK 1115

  Fly  1088 VGDKRKLKECYQLMKSLGNG 1107
            |||:|...:|.|::..||.|
Human  1116 VGDRRSCNDCQQMIVKLGGG 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_524166.2	PAT1	<55..>229	CDD:401645	43/187 (23%)
		bHLHzip_SREBP	279..351	CDD:381400	40/78 (51%)
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000269|PubMed:35120642	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144		12/50 (24%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		92/275 (33%)
		bHLHzip_SREBP2	326..402	CDD:381492	39/78 (50%)
		Leucine-zipper	380..401		8/23 (35%)