Protein Alignment SREBP and SREBF1

DIOPT Version :10

• Sequence 1: NP_524166.2
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_001005291.1
• Gene: SREBF1 / 6720
• HGNCID: 11289
• Length: 1177
• Species: Homo sapiens
• Alignment Length: 1223
• Identity: 391/1223 - (31%)
• Similarity: 541/1223 - (44%)
• Gaps: 214/1223 - (17%)

  Fly     7 NLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDIILN-DMDLAPTQMYNMLLDEPRT-----HTQ 65
            |.:||| ....|....:..||        |||.:|.| |.|      :..|.|.|..     .|.
Human    41 NGLDAP-RAGADRGAMDCTFE--------DMLQLINNQDSD------FPGLFDPPYAGSGAGGTD 90

  Fly    66 QTQSVDQQPQSVEQQPHVKSEH-----SSPVHIKEELHQQQQQSPLLVYKPDPLIATSY-NCPQQ 124
            ........|.|:...|...|..     |.|         |...|||...:|.|.....| :.|..
Human    91 PASPDTSSPGSLSPPPATLSSSLEAFLSGP---------QAAPSPLSPPQPAPTPLKMYPSMPAF 146

  Fly   125 QP-TGLLKAAQPTATIHHMDAQRMP----PNT--AVYPPSLGSSFVYQSMSPPTSPVESANQNVN 182
            .| .|:.:.:.|.:.:.....|.:|    |.:  |..||...|:.|....||| ....:.:...|
Human   147 SPGPGIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPP-GGFSTGSPPGN 210

  Fly   183 VMQPVAATPAPASAPLP--------QQSYPQPFITYNS-------KAGMTSD-EAMYFLLQP--- 228
            ..||:...|..:...:|        |...||..:|..:       ...:||. :.:..||||
Human   211 TQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLLQPHFI 275

  Fly   229 ---------------TVASPTPSPPVAPPPTSTGSRASKVRVAP-LAPSPAAMEVQGKVPINRV- 276
                           ||.:...||.|:.....||...:.|.... ||..|..::.: |:||||:
Human   276 KADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAE-KLPINRLA 339

  Fly   277 -------QPKVKEVKRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRDLQ 334
                   ..:.:..||:||||||:|||:||||||.|||:||||.:|||||||||||:||.||.||
Human   340 AGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQ 404

  Fly   335 RQNHDLKAELQRLQRELMARDGSKVKDLLQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDP 399
            ..|..||.|  .|...........:|||:. ....|..:....|..:|...|. ||||.||...|
Human   405 HSNQKLKQE--NLSLRTAVHKSKSLKDLVS-ACGSGGNTDVLMEGVKTEVEDT-LTPPPSDAGSP 465

  Fly   400 SLSPMHSDISLPPSPYGGSTASCSSGSSSSNE-----------EPLVVPS-SMRGMATHSRLGLC 452
            ..|   |.:||      ||..|.|.||.|.:|           :|...|| ..|||...|||.||
Human   466 FQS---SPLSL------GSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLALC 521

  Fly   453 MFMFAILAVNPFKTFLQRGHYDSNDDLGDM--SGQRRILSYDV-EGEGFAVWQQSSWIWLLNFTL 514
            ..:|..|:.||..:.|......|..|...:  |..|.:|..:. :|.|:|.|.....:||||..|
Human   522 TLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGWAQWLLPPVVWLLNGLL 586

  Fly   515 MLGCLVKLLVYGDPQLDAQTDA---YCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRL 576
            :|..||.|.|||:|.....:..   :.:||::||...::|..:||.......|...|..||.|.|
Human   587 VLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHL 651

  Fly   577 ECYLQTTWQFLRFLFHRLWLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGS 641
            :......|..:|.|..|||:||.|:.|:|||..:.|.|..|.||||:.||::::|:||...|..:
Human   652 DLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLHQLHTMGKHT 716

  Fly   642 RGDMNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECG 706
            .|.:....:||.|.|:||.|.:.::......|:|..|||:|.|.|:.|..| .|:::|.|||.|
Human   717 GGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALHFL-TRFFLSSARQAC- 779

  Fly   707 LTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLLF 771
            |.::......::|.....|:|:.....::. ||...|  ..::...||.||.|.|.:.:|||||.
Human   780 LAQSGSVPPAMQWLCHPVGHRFFVDGDWSV-LSTPWE--SLYSLAGNPVDPLAQVTQLFREHLLE 841

  Fly   772 KAIQCLVGAGHKSGGLPTSSVSGEAEQLQQQQHSGTIVSNVLKYTSLLK---------------D 821
            :|:.|:.......|     |..|:.|           .|:.|.|..||.               .
Human   842 RALNCVTQPNPSPG-----SADGDKE-----------FSDALGYLQLLNSCSDAAGAPAYSFSIS 890

  Fly   822 TLWADEDERDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPK-ALHAV 885
            :..|.....|....|||.:....:|||..::..||:|...::.:|..||:  ....||: |||:.
Human   891 SSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQE--SERPLPRAALHSF 953

  Fly   886 LRAKMILLKNNGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETR 950
            ..|:.:|    |.|..:|....:.| |:::|..||:.|.....:.:  |....||..||.||..|
Human   954 KAARALL----GCAKAESGPASLTI-CEKASGYLQDSLATTPASSS--IDKAVQLFLCDLLLVVR 1011

  Fly   951 TALWELEHMNMEDDGFYQVPGEV----------------LEKFQTDLNSLRNIVENIPNAQSRIY 999
            |:||..:          |.|...                |..||.||:|||.:.::...|..|::
Human  1012 TSLWRQQ----------QPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRPAMRRVF 1066

  Fly  1000 LYEAVCRLMAGASPCPTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGG----------ERERAS 1054
            |:||..||||||||..|.||||||||.|...     |.|        ||          .||.|.
Human  1067 LHEATARLMAGASPTRTHQLLDRSLRRRAGP-----GGK--------GGAVAELEPRPTRREHAE 1118

  Fly  1055 AMYVACKYLPPALLSSPGERAGMLAEAAKTLEKVGDKRKLKECYQLMKSLGNG 1107
            |:.:|..||||..||:||:|.|||||||:||||:||:|.|.:|.|::..||.|
Human  1119 ALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGG 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_524166.2	PAT1	<55..>229	CDD:401645	47/225 (21%)
		bHLHzip_SREBP	279..351	CDD:381400	46/71 (65%)
SREBF1	NP_001005291.1	Herpes_BLLF1	<79..350	CDD:282904	61/281 (22%)
		Atrophin-1	<117..>240	CDD:460830	30/132 (23%)
		bHLHzip_SREBP1	349..423	CDD:381491	46/75 (61%)