Protein Alignment SREBP and sre2

DIOPT Version :10

• Sequence 1: NP_524166.2
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_595229.1
• Gene: sre2 / 2541044
• PomBaseID: SPBC354.05C
• Length: 793
• Species: Schizosaccharomyces pombe
• Alignment Length: 595
• Identity: 138/595 - (23%)
• Similarity: 204/595 - (34%)
• Gaps: 195/595 - (32%)

  Fly    16 SMDLFKAEDVFEPFDADLHSDMLD---IILNDMD------LAPTQMYNMLLDEPRTHTQQTQSV- 70
            |||   |...|     :|:.|:.|   :..|.:|      |.|.:. |....:.:.|::|..|.
pombe    87 SMD---ASTAF-----NLNQDVADKPMLARNSIDSSINTELGPLES-NHWFTQAQDHSRQYSSSW 142

  Fly    71 --------------DQQPQSVEQQPHVKSEHSSPV--HIKEELHQQQQQSPLLVYKPDPLIATSY 119
                          |....|:...||:...|....  |..|.|  |..|.|:...|...|..|..
pombe   143 DPSIDPFEVKNSLHDSTDLSITHHPHLPINHQGNTWKHANESL--QSNQGPVPNTKFVGLETTQT 205

  Fly   120 NCPQQQPTG---LLKAAQPTATIHHMDAQ----RMPPNTAVYPPSLGSSFVYQSMSPPTSPVESA 177
            :..||....   .::.|..|..:.....|    ....|.::.|.||..:|...:..|..:.::|.
pombe   206 DSYQQSSVNSVVKIEEADATYALREESGQFNTFTGAENPSISPHSLNPNFPQYTEKPALTLLQSP 270

  Fly   178 NQNVNV-MQPVAATPAPASAPLPQQSYPQPFITYNSKAGMTSDEAMYF-LLQPTVASPTPSP--- 237
            .||.|. ......:.:.:|.....:..|.|.     |..|:||:|:.| ..|.:...|..:|
pombe   271 KQNSNYDTSNFQNSVSDSSMQFTNEGMPSPV-----KGIMSSDDAVAFNFSQYSTVYPQNAPENG 330

  Fly   238 -----------PVAPPPTSTGSRASKVRVA--------------PL-APSPAAMEVQGKV----- 271
                       .|:.|..|..|:.|...:|              |. :||.::..|:|.|
pombe   331 NEFETPNKLKRTVSSPCASISSKRSYGDIAQDCSYISSKTNGGGPSDSPSSSSTSVRGSVNDSNS 395

  Fly   272 PI----------NRVQP---KVKE------VKRSAHNAIERRYRTSINDKI-------------- 303
            ||          |.|:|   ..:|      .||||||.||:|||:::||||
pombe   396 PISSSATFAIQSNGVEPVGLSTQEQNLSPLSKRSAHNMIEKRYRSNLNDKIAELRDAVPTLRSGY 460

  Fly   304 -----NELKNLVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDGSKVKDLL 363
                 :|||...|....||||:.:|.|:.:.|:.||.:|..|..|.:.||:.|     |:...::
pombe   461 NSTTADELKGTYVPLSRKLNKATILSKATEYIKSLQSKNKKLIEENKILQKRL-----SEYTSVI 520

  Fly   364 QL-----------------GTRPG--------RASKKRRESSQTFTTDA----GLTPPRSDESDP 399
            |.                 |..||        :.|.....|.|.:..||    ...|..|....|
pombe   521 QASLTAPSQPASLSLLGPPGNTPGHRNVPPILKRSSIGTPSQQAYFPDAPHNCHSVPQNSSYPRP 585

  Fly   400 SL----SPMHSDISLP---------------------------------PSPYGGSTASCSSGSS 427
            .:    ||:.|..::|                                 |..||||..| |:..|
pombe   586 PMQVNRSPIDSMQTIPHANFNEMHNAYSSRYPLKYSKSCNAVSHTSMMHPQEYGGSLPS-STVPS 649

  Fly   428 SSNEEPLVVP 437
            ..|:..||.|
pombe   650 DYNQPQLVSP 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_524166.2	PAT1	<55..>229	CDD:401645	42/199 (21%)
		bHLHzip_SREBP	279..351	CDD:381400	34/96 (35%)
sre2	NP_595229.1	bHLHzip_scHMS1_like	425..517	CDD:381405	35/96 (36%)