Protein Alignment SREBP and Srebf2

DIOPT Version :10

• Sequence 1: NP_524166.2
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_150087.1
• Gene: Srebf2 / 20788
• MGIID: 107585
• Length: 1130
• Species: Mus musculus
• Alignment Length: 1123
• Identity: 344/1123 - (30%)
• Similarity: 525/1123 - (46%)
• Gaps: 132/1123 - (11%)

  Fly    26 FEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQSVDQQPQSVEQQPHVKSEHSSP 90
            |.|..|...:..|.:     .::||......:.:||...|.......|.|:|...|...:...:.
Mouse    93 FSPSAASPQAPALQV-----KVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTR 152

  Fly    91 VHIKEELHQQQQQSPLLVYKPDPLIATSYNCPQQQPTGLLKAAQPTATIHHMDAQRMPPNTAVYP 155
            : |::.|..|...:...|.:|.  :.:....||.||..:.:..|.      :.|||:...||
Mouse   153 I-IQQPLIYQNAATSFQVLQPQ--VQSLVTSPQVQPVTIQQQVQT------VQAQRVLTQTA--- 205

  Fly   156 PSLGSSFVYQSMSPPTSPVESANQNVNVMQPVAATPAPASAPLPQ-QSYP---QPFITYNSKAGM 216
                 :...|:::|.|            :|.|||         || |..|   ||.|.......:
Mouse   206 -----NGTLQTLAPAT------------VQTVAA---------PQVQQVPVLVQPQIIKTDSLVL 244

  Fly   217 TSDEAMYFLLQPTVASPTPSPPVAP-------PPTSTGSRASKVRVAPLAPSPAAMEVQGKVPIN 274
            |:.:.....:...|.:|..:...||       .||..||..:.:...|:      |..|.||||.
Mouse   245 TTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPV------MMGQEKVPIK 303

  Fly   275 RVQPKVKEV-------KRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRD 332
            :|...||::       :|:.||.||:|||:||||||.|||:||:|..||::||.||||:||.|:.
Mouse   304 QVPGGVKQLDPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKY 368

  Fly   333 LQRQNHDLKAELQRLQRELMARDGSKVKDLLQLGTR-PGRASKKRRESSQTFTTDAGLTPPRSDE 396
            ||:.||.|:.|...|:   :|...:|:...:.||:. ......|..:.:|....   ::||.||.
Mouse   369 LQQVNHKLRQENMVLK---LANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLL---MSPPASDS 427

  Fly   397 -SDPSLSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILA 460
             |....||...| |.|.||.        ...:...:||...|.:: ||...||:.||:..|..|:
Mouse   428 GSQAGFSPYSID-SEPGSPL--------LDDAKVKDEPDSPPVAL-GMVDRSRILLCVLTFLGLS 482

  Fly   461 VNPFKTFLQRG--HYDSNDDLGDMSGQ-RRILSYDVEGEGFAVWQ-QSSWIWLLNFTLMLGCLVK 521
            .||..:.||.|  |   |.|....||. |.:||.:....|:..|. .:..:||:|..::|...||
Mouse   483 FNPLTSLLQWGGAH---NTDQHPYSGSGRSVLSLESGAGGWFDWMVPTLLLWLVNGVIVLSVFVK 544

  Fly   522 LLVYGDPQL---DAQTDAYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQTT 583
            |||:|:|.:   ...:..:.:||::||...::|..:.|.|....||.:.|.:||.|||:.....:
Mouse   545 LLVHGEPVIRPHSRPSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLS 609

  Fly   584 WQFLRFLFHRL----WLGRVLSRRSGGLFSNAAS-RKQALASARELALLFNRLNQLQLTGNGSRG 643
            |..:|:...:|    ||.:.:.:|.....:.||. ..:|.:|||:.||.::||:||.:||....|
Mouse   610 WNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAG 674

  Fly   644 D-MNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECGL 707
            . .:.:.|||.|.|:||.|...:.|...|.||:..|:.:|......|..| |.|:::||:..||.
Mouse   675 SACSDVHMALCAVNLAECAEEKILPSTLIEIHLTAAMGLKTRCGGKLGFL-ASYFLNRAQSLCGP 738

  Fly   708 TRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLLFK 772
            ..:| ....|||.....|.::.....::.   .|..::..:...|:|.||.|.|.:.:.::||.:
Mouse   739 EHST-VPDSLRWLCHPLGQKFFMERSWSI---KSAAKESLYCAQRSPADPIAQVHQAFCKNLLER 799

  Fly   773 AIQCLV--GAGHKSGGLPTSSVS-GEAEQLQQQQHSGT----IVSNVLKYTSLLKDTLWADEDER 830
            |::.||  .|..|:|.....|.. ..|.:..:..||..    .|::....:|:|:..|..|...|
Mouse   800 AVESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGFVTSPFSSSSVLRSALGPDVICR 864

  Fly   831 DTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAVLRAKMILLKN 895
                 ||...:..|:.||.|:|......:..::::|..|:.  ....|.||:....||....|..
Mouse   865 -----WWTSAVTMAISWLQGDDAAVRSRFTEVERVPKALEV--TESPLVKAVFYTCRAMHASLSG 922

  Fly   896 NGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETRTALWELEHMN 960
            ..:....|...     |:.:|..|...|.|:..|....:..:.||.|||.||..|||||:.:...
Mouse   923 KADGQQNSFCH-----CERASGHLWSSLNVSGTTSDPSLNHVIQLFTCDLLLSLRTALWQKQASA 982

  Fly   961 MEDDG-FYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLMAGASPCPTQQLLDRSL 1024
            .:..| .|...|..|..||.||.|||.:..:...|..:::|:||..||||||||..|.|||:.||
Mouse   983 SQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSL 1047

  Fly  1025 RSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGERAGMLAEAAKTLEKVG 1089
            |.|...::.. |..|...     |:||||:|:.:||::||.:.|||||:||.:|||||:||||||
Mouse  1048 RRRPTQNTKH-GEVDTWP-----GQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVG 1106

  Fly  1090 DKRKLKECYQLMKSLGNG 1107
            |:|...:|.|::..||.|
Mouse  1107 DRRSCSDCQQMIVKLGGG 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_524166.2	PAT1	<55..>229	CDD:401645	37/177 (21%)
		bHLHzip_SREBP	279..351	CDD:381400	40/78 (51%)
Srebf2	NP_150087.1	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956, ECO:0000250|UniProtKB:Q12772	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..133		9/44 (20%)
		Interaction with LMNA. /evidence=ECO:0000269|PubMed:11929849	226..480		90/275 (33%)
		bHLHzip_SREBP2	315..391	CDD:381492	39/78 (50%)
		Leucine-zipper	369..390		8/23 (35%)