Protein Alignment SREBP and SREBP

DIOPT Version :10

• Sequence 1: NP_524166.2
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: XP_311076.6
• Gene: SREBP / 1272195
• VectorBaseID: AGAMI1_006028
• Length: 1234
• Species: Anopheles gambiae
• Alignment Length: 1271
• Identity: 498/1271 - (39%)
• Similarity: 671/1271 - (52%)
• Gaps: 230/1271 - (18%)

  Fly    18 DLFKAEDVFEPFDADLHSDMLDII-LNDM----DLAPTQMYNM----LLD------------EPR 61
            |.|....:|.| :.....|.|||. :|||    |:|  :||.|    ||:            |..
Mosquito     9 DPFHQPGLFFP-NTGFKEDELDIADMNDMSDIVDIA--EMYQMNEEKLLNMMGEDFLSTLSWEGT 70

  Fly    62 THTQQTQSVDQQPQSVEQQPHVKSEHSSPVHIKEELHQQQQQSPL-------LVYKPDPLIATSY 119
            .......:......|......:.|...:.|.||||...|::.|.:       .:::|.|..:|..
Mosquito    71 IGDTSAAAAAASGSSSSASMAIPSPSGAGVTIKEECVGQKEPSAVPPSSPSDTLFQPIPKSSTPL 135

  Fly   120 NCPQQQPTGLLKAA---QPT--AT---------------IHHMDAQRMPPNT-----AVYPPSLG 159
            ..|:|:...:|..|   |||  ||               :|...|..:...|     |...|::.
Mosquito   136 QSPKQEEKQVLLCAPQLQPTPAATSLPTLAPQPHDHGQQLHLQPASHLVAGTRSVILAPSRPTMA 200

  Fly   160 SSFVYQSMSP-PTSPVESANQNVNVMQPVAAT----PAPASAPLPQQSYPQ-------PFI---- 208
            ...|  :.:| .||..::|....|...||..|    .|||.|| |||...|       |.|
Mosquito   201 GQAV--ATTPTTTSTTQTALLLQNARTPVTQTYQKKIAPAPAP-PQQQQQQQQTANLLPGIANVR 262

  Fly   209 TYNSKAG-----------MTSDEAMYFLLQPT-----------VAS--PTPS------------- 236
            ..|..||           .|.|:...||...|           :||  |.||
Mosquito   263 VQNLVAGGQPLMQQVFTLQTVDKQSVFLPANTPVIYANANVHSIASTAPVPSTVTVKTSPNLHTL 327

  Fly   237 -------------PPVAPPPTSTGSRASKVRVAPLAPSPAAMEVQGKVPINRVQ----PKVKEVK 284
                         |.|...||...:.|:    |..|||..:.:.|.||.:.|:|    |||||||
Mosquito   328 VNTLSGPILAAGIPVVLDAPTQVTAAAA----AAAAPSQQSADGQPKVQLTRLQPAGVPKVKEVK 388

  Fly   285 RSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQR 349
            ||||||||||||||||..|.||||:|||..|||||||:|||:||.||.||:||:.||.|....:.
Mosquito   389 RSAHNAIERRYRTSINSCIVELKNIVVGVDAKLNKSAILRKAIDHIRHLQKQNNQLKQENMTYKM 453

  Fly   350 ELMARDGSKVKDLLQLGTRPGRASKKRRESSQTFTTD---AGLTPPRSDESDPSLSPMHSDISLP 411
            .| |.....:||||     .|:..:::.........|   ..:||||||||:||.||.|||.|:.
Mosquito   454 RL-ADQKHSLKDLL-----VGQQQQQQHHHPHHMVDDLMIGPITPPRSDESNPSSSPAHSDSSML 512

  Fly   412 PSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILAVNPFKTFLQ--RGHYD 474
            .||:.||.:..|:|.....::.::  |.:.||::::||.:||||.|:|.||||.:.|.  .|..|
Mosquito   513 GSPFPGSGSLSSNGGDDLLDDEML--SGLGGMSSNARLTICMFMLAVLVVNPFGSLLSLAGGRPD 575

  Fly   475 SNDDLGDMSGQRRILSYDVEGEGFAVWQQSS---WIWLLNFTLMLGCLVKLLVYGDPQL----DA 532
            :.::||.   .||||:  ||...|  |.:.|   .:.|:|...:..|||::||||||.|    .|
Mosquito   576 APEELGT---TRRILA--VEEPYF--WSRLSSMLLVALVNLMFLAFCLVRMLVYGDPVLLPRSRA 633

  Fly   533 QTDAYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQTTWQFLRFLFHRLWLG 597
            .|| |.:|::::|..|.:|.:..:|.....||..||||||::|::....|.|||:|..||||::|
Mosquito   634 STD-YWKHKRQSDVEFRRGNADASYREAKLCLQSFGLSLPSTRVQRVSATAWQFVRMFFHRLYIG 697

  Fly   598 RVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGSRGDMNGIMMALFASNMAEVAH 662
            |.||||:||||.....|..||.||||||||::|||||.|..|  |.|.||:||:|.|.||||.|.
Mosquito   698 RWLSRRTGGLFKPEGDRMHALHSARELALLYHRLNQLHLVTN--RTDANGLMMSLCAVNMAETAA 760

  Fly   663 NLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECGLTRATEQT-QELRWAFTAYGY 726
            ::::..:||.|:::.|||:|||.|: |.|.:.|||:::|:|     .|::.| :..||.||.||:
Mosquito   761 SVISVDDTIEIYLLAALRVKRSYPR-LLQYYCRYYLAQAKQ-----LASDHTSRRFRWLFTPYGF 819

  Fly   727 RYCATHVFTYDLSDSGEQ-DG---FFTRLRNPCDPAAHVIKQYREHLLFKAIQCLVGAGHK---- 783
            |:..|..|.|     ||: ||   .||.|.|..||..:|:::||.:||.:|:|.|||:||:
Mosquito   820 RFLTTSRFRY-----GERMDGSTALFTTLCNSADPIEYVMREYRLNLLQQALQLLVGSGHERTVR 879

  Fly   784 -SGGLPTSSVSGEA--------EQLQQQQHSGT--------------IVSNVLKYTSLLKDTLWA 825
             .|..|.|...|.|        ::.::..|.|:              :..::|.:|.||:||...
Mosquito   880 DPGSGPGSPGKGSAAGPGPLTGKETKEDHHHGSKSSEAADLTATGSGVSGDILHFTELLQDTFGL 944

  Fly   826 DEDER-------------DTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDH 877
            ::...             |....||.::|..|..||||||.|||.|||:::.:|..:||.  .|.
Mosquito   945 EKPVPFDGCSVHGTDCCFDELAHWWCNLLRVAGFWLLGEDELAEALYGQVETLPAAMQQL--EDP 1007

  Fly   878 LPKALHAVLRAKMILLKNNGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLT 942
            |.:||.....||..|:....::.:.....     |:.||..|::.||.|.......:|||.|||.
Mosquito  1008 LARALLLAFHAKRGLITKTESSFETIFGH-----CNASSRFLEDSLTGNICKTPSRLKLLSQLLA 1067

  Fly   943 CDWLLETRTALWELEHMNMEDDGFYQ-VPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCR 1006
            ||||||.||||||:|.....:...:| |||::|..||.|||.||.:....||||||::|||||||
Mosquito  1068 CDWLLEARTALWEIEKDMRYNQQLHQTVPGQILAAFQADLNLLRMVTSKFPNAQSRVFLYEAVCR 1132

  Fly  1007 LMAGASPCPTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSP 1071
            |||||:|.|||||||||||.||:.||:.|| |||..|  :.|.||||:|:|||||:||...||||
Mosquito  1133 LMAGAAPGPTQQLLDRSLRQRNSRSSLICG-KDRSAQ--LAGGRERAAALYVACKHLPAPCLSSP 1194

  Fly  1072 GERAGMLAEAAKTLEKVGDKRKLKECYQLMKSLGNG 1107
            |||||||.||||||||:|||::|::|||||||||:|
Mosquito  1195 GERAGMLEEAAKTLEKIGDKKRLQQCYQLMKSLGSG 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_524166.2	PAT1	<55..>229	CDD:401645	57/248 (23%)
		bHLHzip_SREBP	279..351	CDD:381400	51/71 (72%)
SREBP	XP_311076.6	None