DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and LON2

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_568675.1	Gene:	LON2 / 834750	AraportID:	AT5G47040	Length:	888	Species:	Arabidopsis thaliana

Alignment Length:	980	Identity:	324/980 - (33%)
Similarity:	495/980 - (50%)	Gaps:	181/980 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 TVAVPDVWPHVPLLAMRKNPLFPRFMKIVEVSNPIIMDLLRRKV--KLNQPYVGVFLKKTDGEEE 146
            ||.:|.   .:.:|..|...|.|..:..:..::...:.|:.:::  |..:..:|:...:.|.|..
plant     4 TVELPS---RLAILPFRNKVLLPGAIIRIRCTSHSSVTLVEQELWQKEEKGLIGILPVRDDAEGS 65

  Fly   147 LITNLNDVYNLGTFAQIQELQDLGDK-LRMVVVAHRRIRITGQVVEDVPPPKPVKMTTLHYPLFN 210
                     ::||........|.|:: |:.:|
plant    66 ---------SIGTMINPGAGSDSGERSLKFLV--------------------------------- 88

  Fly   211 IKLQIPAEDQSTDQADAAPIKSRSDPARKPRGRIPRSRTGKSRESAAAEELIQNQTLEPPLKSGK 275
                      .|..|..:..|.:.|.....||             .||..|..::.:|.|  ||:
plant    89 ----------GTTDAQKSDAKDQQDLQWHTRG-------------VAARALHLSRGVEKP--SGR 128

  Fly   276 VESSSLPKPPTEEKIVEPETGAKENVNQSAP----SAQPVLIVEVENVKQPIYKQTEEVKALTQE 336
            |           ..:|..|..::.||.:...    |...:..:|:...:....||..:..||:::
plant   129 V-----------TYVVVLEGLSRFNVQELGKRGPYSVARITSLEMTKAELEQVKQDPDFVALSRQ 182

  Fly   337 IIKTLRDIITMNPLYRESLQQMLHQNQRVVDN--------PIY-LCDLGASLSAGEPAELQKILE 392
            ...|..::::           :|.|.|:....        ||: |.|:..:.......|...:|:
plant   183 FKTTAMELVS-----------VLEQKQKTGGRTKVLLETVPIHKLADIFVASFEMSFEEQLSMLD 236

  Fly   393 ETDIPERLQLALTLLKKELELSRLQQKIGREVEEKVKQQHRKYILQEQLKVIKKELGIEKDDKDA 457
            ..|:..||..|..|:.:.|:..|:.:||.::||.::.:..::|:|::|::.||:|||...||:|.
plant   237 SVDLKVRLSKATELVDRHLQSIRVAEKITQKVEGQLSKSQKEYLLRQQMRAIKEELGDNDDDEDD 301

  Fly   458 IGEKYREKLKDKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTSLPWGVISTEN-LCL 521
            :....| |::...:|..|......||.:|..::.....:|.:|.||:.|..|||...|.|: |.|
plant   302 VAALER-KMQAAGMPSNIWKHAQRELRRLKKMQPQQPGYNSSRVYLELLADLPWDKASEEHELDL 365

  Fly   522 EKATETLNDDHYGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSIAKSIARALNREYF 586
            :.|.|.|:.||||:..:|:||:|::||..||...:|.:|||.|||||||||:|.|||.||.|::.
plant   366 KAAKERLDSDHYGLAKVKQRIIEYLAVRKLKPDARGPVLCFVGPPGVGKTSLASSIAAALGRKFV 430

  Fly   587 RFSVGGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIGKGYQGDPSSALLEL 651
            |.|:||:.|.|:|:||||||:|:|||:||..||:..:.||::|:||:||.|...:|||:|||||:
plant   431 RLSLGGVKDEADIRGHRRTYIGSMPGRLIDGLKRVGVCNPVMLLDEIDKTGSDVRGDPASALLEV 495

  Fly   652 LDPEQNANFLDHYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGYVAEEKIAIARQYLM 716
            ||||||.:|.||||:||.|||:|:|:.|||.:..||.||.|||||||:.||..|||:.||.::|:
plant   496 LDPEQNKSFNDHYLNVPYDLSKVVFVATANRVQPIPPPLLDRMELIELPGYTQEEKLKIAMRHLI 560

  Fly   717 PQAMKDCGLTDKHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFRVVKKEGEHFPVNAD 781
            |:.:...||:.:.:.|.|..:..:|:.|.||:|||:|::::..:.|..|..|.:.| :..|::.|
plant   561 PRVLDQHGLSSEFLKIPEAMVKNIIQRYTREAGVRSLERNLAALARAAAVMVAEHE-QSLPLSKD 624

  Fly   782 --NLT------------------------------TF----------------LGKQIF----SS 794
              .||                              ||                ||...|    ::
plant   625 VQKLTSPLLNGRMAEGGEVEMEVIPMGVNDHEIGGTFQSPSALVVDETMLEKILGPPRFDDSEAA 689

  Fly   795 DRMYATTPVGVVMGLAWTAMGGSSLYIETSRRHIRQGAKTDPNTVAGSLHITGNLGDVMKESAQI 859
            ||:   ...||.:||.||..||...::|.:..           ...|.:|:||.||||:|||||:
plant   690 DRV---ASAGVSVGLVWTTFGGEVQFVEATSM-----------VGKGEMHLTGQLGDVIKESAQL 740

  Fly   860 ALTVAR----NFLYSLEPNNLFLEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDI 920
            |||..|    :|..:|..:...|:...||:|.|.||.||||||||:|::||||||.:.|.||.|.
plant   741 ALTWVRARASDFKLALAGDMNVLDGRDIHIHFPAGAVPKDGPSAGVTLVTALVSLFSQKRVRADT 805

  Fly   921 AMTGEVSLKGKVLPVGGIKEKTIAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDV 985
            |||||::|:|.||||||||:|.:||.|.|:..:|||..|.||..|:|..:...|||..|...|||
plant   806 AMTGEMTLRGLVLPVGGIKDKILAAHRYGIKRVILPQRNSKDLVEVPAAVLSSLEVILAKRMEDV 870

  Fly   986 YKIAF 990
            .:.||
plant   871 LENAF 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740	9/56 (16%)
		lon	95..990	CDD:273258	319/967 (33%)
		P-loop_NTPase	530..>581	CDD:304359	29/50 (58%)
		AAA	560..702	CDD:278434	88/141 (62%)
		ChlI	778..991	CDD:304493	101/269 (38%)
LON2	NP_568675.1	lon	12..875	CDD:273258	319/967 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D528132at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720