Protein Alignment ash1 and kmt2ba

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_073787587.1
• Gene: kmt2ba / 560856
• ZFINID: ZDB-GENE-060503-376
• Length: 2945
• Species: Danio rerio
• Alignment Length: 1921
• Identity: 371/1921 - (19%)
• Similarity: 599/1921 - (31%)
• Gaps: 701/1921 - (36%)

  Fly    39 SKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKK 103
            |||..|..|..||....:||...:..::.:|.:...:...:.......:...|.|......|.||
Zfish  1289 SKSFCSGWQDVVQEVLRNGLEKIMGGLKNSLNISHLRLCAQCEACPDFEVVKGRSGCCLHPVEKK 1353

  Fly   104 VKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASK 168
            ::         :|:..|.|             |..||.:.:.|.:.|....||        .|.:
Zfish  1354 LE---------NGLYTSLK-------------SFHEDVVKVMVERLRREEYLL--------EAQR 1388

  Fly   169 PTLDIGI---------------------SSSDNELPN--LVQAAIKRVESDTEDTTVEGSFRKAA 210
            ||....:                     ||:..|.|.  |.:|.|        ..:.|.|:.:..
Zfish  1389 PTSQAKLYYIKLVEQVFSWFNSQDPKTWSSNVQEFPRGMLPEAII--------PPSNEHSYAQWL 1445

  Fly   211 KDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVP 275
            ||::....||        |.|   |.:|:|..:|     ::.:|.|      :.|..|
Zfish  1446 KDQHPGSPQS--------KDQ---QKINSKPLDE-----RQCSLCQ------QHGDAK------- 1481

  Fly   276 APGNSGPAI----NESADSGVISTTSTTQSTTPS-----------PKMQNENAVPTGSLPIASSS 325
             |.::|..:    ||.|.......::..|.|..:           ..|:.|....||:......:
Zfish  1482 -PNDAGRLLYIGQNEWAHVNCCIWSAEVQETNGALLHVHSAVARGRFMRCERCGQTGATVGCCLT 1545

  Fly   326 KPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSM 390
            ..:.:..::..|  |:..|.         |::||..|...           ||: :|.|..
Zfish  1546 SCQSNYHFMCAR--ASNCVF---------QHDKKVYCYKH-----------REL-INSKIE---- 1583

  Fly   391 SVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQR----------------SSHNHNSGYKSDA 439
                 .|.|..        ..:..|| |:..:..:|                |.|..|.|..::.
Zfish  1584 -----QGNGFE--------VVRRVYV-DFDGISLRRKFLTGLEPESVNVMIGSLHVKNLGVLTEL 1634

  Fly   440 SCK-----------SRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDT 493
            |..           ||:...:...||    .|.|.....|...|    .|.|..|.::....:.|
Zfish  1635 SANSGKLYPVGYQCSRWYWSTVDPRR----RCRYTCKVSEVRPS----TRCRTPSFMVDQGENHT 1691

  Fly   494 V-------EDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRG 551
            :       .|:|         |..||..:        ..||.::.||          |.|..|.|
Zfish  1692 IVHSPKAQNDED---------GTDSESFS--------PGLPLSTPSK----------TKQDSGSG 1729

  Fly   552 G---------------SLSATNPDNFISK-----MMNQRKETPAPSKSSCKIKSRRSSAASMCSS 596
            |               |....:|.|.:|.     .::...||    :.|.:..|.||..||....
Zfish  1730 GRTPGYPHSRRPAGGMSRPLPSPGNALSTSHHILTISDLDET----RRSTRRHSTRSRNASPPPV 1790

  Fly   597 YVSGVSRMRR----RHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLL 657
            .:||...:|.    ..|..|||...|      .|...|.:.||.:.|.|.:...|:.||    ::
Zfish  1791 ILSGPMALRSGGSINPRSLSFSPPVS------PLGATENLMSTTSPRRRGRPPSLSPSS----II 1845

  Fly   658 ADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSG 722
            :..:..||.|.:||.|...|::   .:..|.:|..  ....|..:.:.||......|:|.|
Zfish  1846 SGPSPPQAALRSPSSALPSTVH---HSPRLQQPFT--TSPHKTDKVVQDFLSEPEEAAGAP---- 1901

  Fly   723 SSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFA---NGKL---------- 774
                                      .||..|.||:|...|..:||.|   |.||
Zfish  1902 --------------------------VLKSDHDLLSPHFDPDTDVAVASVLNAKLEFDEALLNEN 1940

  Fly   775 ------------NAEAWAAAAAAAKSTASTKSQAQFN---------------------ARSVKSA 806
                        ..|..|....|.:...|:.::.|..                     |:..::.
Zfish  1941 VALDCDPQGAEGELEEEACKYNAGRKDLSSIAEMQMETDDEVADHYLNFSRTVVVCEPAKDTQTG 2005

  Fly   807 LTPKKRHLLEQPTSVS---GA--------------------GS---SASNSPLRIVVDN--NSIS 843
            ||     :|....|:|   ||                    ||   |....||:|...|  .::.
Zfish  2006 LT-----VLPNSGSISQLDGADNDSESDTGEANADDNTQEVGSSFLSQDTEPLKITGQNKGTTLG 2065

  Fly   844 GGKLL--DI-SPSSLCSLKQQRRGG-------AAKQKVSAAKDLVQLQSPAGS------------ 886
            .|:|:  :| :|.:..|:.:..:..       ..:|:||:.:|...|...|||
Zfish  2066 DGQLVCTEIANPHTADSVDENAKPETQNIEQVCEEQEVSSLEDNANLLVDAGSDSSNQQEMSFTD 2130

  Fly   887 ---YPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKE----VGQRVVET- 943
               ...|.|::.|       .|....|.::  ||.||...|.....:||...    |..|||::
Zfish  2131 GLNATTPVVYKGS-------DLIATQEEIL--AESESSAGSQEVFLDDTSGNFICTVDGRVVDSP 2186

  Fly   944 -------------LLHKTGGNLLLKRKRKKINRTG--------------FPTVRRKKRKVSVE-- 979
                         .::|.  |::|.|....:.:..              .|::..|:|.|:::
Zfish  2187 KNTADPEGSRDSVPINKE--NVVLNRALSPVEKPAAAVKSSATRTFHVVAPSMPAKRRFVTIQPG 2249

  Fly   980 --------------------------QQTTAVIDEHEPEFDPDDE--------PLQSLRETRSSN 1010
                                      ...|..:..|..:|.|...        |.::|:..|.:.
Zfish  2250 SQPKTFQMAMPVATSIPISVPINVVSTSPTFSVAPHGTQFTPSPVVINGFGAIPKEALKGRRIAI 2314

  Fly  1011 NVNV--QAAP------------------------NPPLDCERVPQAGEARETFVAR--------- 1040
            .:..  |:.|                        ||..:..::|.|.....|.:::
Zfish  2315 RIATPKQSLPHCVPGTPPTPQVLLVNRAGQILVKNPQNNTYQIPSANSPSYTQISQIARIIHGSN 2379

  Fly  1041 -TNQKAPRLSVVALERLQ---RPQTPAR----GRPRGRKPKNREQAEAAPQPPPKSE-----PEI 1092
             ..:..|:::|:.:.:||   ...:|||    ....|..|..:......||..|..:     |
Zfish  2380 VLQRPVPKVTVMPVPQLQACLSRTSPARIISYSSNSGAAPPTQVLIRRIPQSFPGGQLSGVSP-- 2442

  Fly  1093 RPAKKRG-------RQPKQPVLEE-----------PPPTP-------PPQQKKN---KMEPNIRL 1129
             |.:|.|       ::..|.::::           ...:|       .|:.||:   :.:|||.
Zfish  2443 -PLEKAGSISEGGQKELAQVIIDKAMASHREVANATTASPSLLGKRLSPESKKSSTLRTQPNIL- 2505

  Fly  1130 PDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQE-------------- 1180
                   .|...::|:||..::......|:.|      .:.:....|.||:
Zfish  2506 -------ANSRSQVRIKRVSSVTERIGVKRCK------TDFLDQMAPSSQDDHSRSNRVRIKAPS 2557

  Fly  1181 -----EIDAEAEAKRLDSIPTEHDPLPASE---SHNPGPQD-------------------YASCS 1218
                 :.|...:.|..||...||:.:...|   :|....||                   ||..|
Zfish  2558 VKEVLDFDGSFDPKNDDSKVAEHERITPKEPIATHANDSQDGGKSHILSSKLGDSSDWAPYAGWS 2622

  Fly  1219 ESSEDKASTTSLRKLSKVKKTYLVAGLFSNH--------------------------YKQSLMPP 1257
             |.|:..|.....|.:.:.:.:|:..:.|..                          .:...:|
Zfish  2623 -SDEESPSPGKQEKCASLYQPHLIFQITSEDGFSVEADSMDVAWKAVMDGVQEARIGCRMEQLP- 2685

  Fly  1258 PAKVNKKPG-------------LEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKL 1309
               .|...|             |.||:..|||      |:|:..|.. ..|:|        ..:|
Zfish  2686 ---FNSINGARVLGVLHDAVLFLLEQLQGASL------CQKHRFRFH-QHEIP--------EEEL 2732

  Fly  1310 PTRNVVPSWNYRKIRTNVYAESVRPNLAGF---DH---PTCNCKNQGEKSCLDNCLNRMVYTECS 1368
            |..   |:   ...|..||......::..|   .|   |.....:..|...:.....|...||
Zfish  2733 PEN---PN---GCARAEVYVRKSTFDMFNFLASQHRQLPESRPCDDDEDDIMLKSSRRATSTE-- 2789

  Fly  1369 PSNCPAGEKCRN-QKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVV-------T 1425
               .|...:.|: :|..:.||  ||.|  :|..|.|:..|..|..|..::||.|.|:       .
Zfish  2790 ---LPVAMRFRHLEKTSKEAV--GVYR--SAIHGRGLFCKRNIEAGEMVIEYAGNVIRAVLTDKR 2847

  Fly  1426 EKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLF 1490
            ||.:..:....|:       ..:|...|:|....|:..||:||||:|||..:..:|.|...:|:|
Zfish  2848 EKYYDSKGIGCYM-------FRIDDFDVVDATMHGNAARFINHSCDPNCYSRVINVEGQKHIVIF 2905

  Fly  1491 AKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            |.|.|..||||||||.|.:.:......|.|...:||
Zfish  2906 ALRKIYRGEELTYDYKFPIEDADNKLHCNCGARRCR 2941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	67/416 (16%)
		AWS	1340..1388	CDD:197795	9/51 (18%)
		SET_ASH1L	1391..1531	CDD:380951	49/143 (34%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
kmt2ba	XP_073787587.1	None