Protein Alignment ash1 and kmt2ca

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_005162602.2
• Gene: kmt2ca / 560793
• ZFINID: ZDB-GENE-080520-3
• Length: 4958
• Species: Danio rerio
• Alignment Length: 2140
• Identity: 378/2140 - (17%)
• Similarity: 603/2140 - (28%)
• Gaps: 894/2140 - (41%)

  Fly     5 QNETAAAKVLETQRAQESGSENEETDSITDQSSQSK--SIKSATQFSVQRS-------------- 53
            |.:....:.:..||:.:....|.:.|:|||...::|  ::|...:..||.|
Zfish  3091 QQQQRDMQAMIRQRSSDPFFPNIDFDAITDPIMKAKMVALKGINKVMVQNSMGMPPMVMNRMQQV 3155

  Fly    54 ------DT----------DGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSK 102
                  ||          || ::.....|||        ||........:::....|...:...:
Zfish  3156 PASHAPDTPAFSQPFFGPDG-KLPPQIARPT--------PPNFGPGFVNESQKKQYEEWLQETQQ 3211

  Fly   103 KVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSAS 167
            .:::::|.|....|..:     ||||:                          |||..:.|:.|.
Zfish  3212 LLQMQQKFLEDQIGAHR-----KSKKA--------------------------LSAKQRTAKKAG 3245

  Fly   168 KPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQM 232
            :            |.|          |.|.|..            ||:.:.|| ::|..:|:.:.
Zfish  3246 R------------EFP----------EEDAEQL------------KNVTEQQS-VVQKQLEQIRK 3275

  Fly   233 LGQTVNAKLAEE-KVAKAKEETLVQTAV--PRK----RRGRPKKVVPTVPA-------------- 276
             .|..:|:|.|| :|.:.:::..:||.:  |.|    .:|:|..::|..|.
Zfish  3276 -QQKEHAELIEEYRVKQQQQQQRLQTGMMGPMKTMPVMQGQPPGMMPVGPPMAQPMMGSMLPMQH 3339

  Fly   277 ----------------PGNSGPAINESADSG------------VISTTSTTQSTTPSP-----KM 308
                            ||.:||.      ||            :.:.....|:..|:|     |.
Zfish  3340 PHFGKPSRMPSMPGWHPGTTGPI------SGPRMPPHLPPQMALPNPAQPLQAQPPAPIAPGGKP 3398

  Fly   309 QNENAVPTGSLPIASSSKPKIDMAYLDKRMYA---TERVLYPPPRSKRRQNNKKTACSSSNKEEL 370
            .....|..|:...||||.|.:  .:.|...::   .||        :||:..::       ::|.
Zfish  3399 GQSGTVAGGNGGGASSSAPHV--KFDDNNPFSEGFQER--------ERRERLRE-------QQEK 3446

  Fly   371 QLDPLWREIDVNK---KFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSD-------------- 418
            |...|.:|::..:   :..|...|:|........:      ||....|.||
Zfish  3447 QRVQLMQEVERQRALQRLELEQQSLGLGPDNNGDS------LAQMPFYNSDLSQEFMQTPRPQQQ 3505

  Fly   419 --------------------YGSVRHQRSSH---------------------------------- 429
                                .||...|...|
Zfish  3506 QQQLGPLFPQQGNVPCDFVGQGSAFMQGGEHRPIPGNGSFGPEMGPNFQPKNPMMPGFSAGRPRP 3570

  Fly   430 ---------NHNSGYKSDASCKSR-----------------YST----KSCMSRRSRAKSCGYRS 464
                     :|..|..|.....|.                 ||.    :....:|||.|.   |.
Zfish  3571 PGFGGTRMPHHGGGEPSSFGMNSTTPLPPNFPGSGQSLIQLYSNIIPEEKGKKKRSRKKK---RD 3632

  Fly   465 DCKESGKSGLRMRRKRRASMLLKSSADDT----------VEDQDILQ-------LAGLSLGQ--- 509
            |..:|.|:.........|.  |.....||          :.|||..:       :.||...:
Zfish  3633 DDADSVKTPSTPHSDITAP--LTPCVSDTSSTPTRSVAIMGDQDTSEFSNPLGSMTGLPSSELEI 3695

  Fly   510 --------------SSEESNEYISKPSLKSLPTTSASKKYG-----------------EINRYVT 543
                          |||..:..:....|:.|.::...|..|                 |:|..::
Zfish  3696 SLSGSTPLRRQTSVSSEAEHGLLHDIKLEKLESSVCQKAEGEAPVGHSAEETGIIKTEEVNEIIS 3760

  Fly   544 TGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRH 608
            ..:........:...|.|.:.|.:.:.|.||.|           .||..|              |
Zfish  3761 HNRTSQSPAQSTKGEPGNELLKHLLKNKNTPPP-----------PSAPLM--------------H 3800

  Fly   609 RRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPA 673
            :..    |:||..:.:.|.:         |:..::.|.....||....|.|   |:.:|  |...
Zfish  3801 QMS----NESLRSEDEGLND---------SKGYLRQDSTDSMSGINSRLTD---LEPSL--PEQC 3847

  Fly   674 QQLTLNGGGPASTLSKPLKRGLKKRK---------------------------LSEPL--VDFAM 709
            ::...|...|.:.:.||..|..|::|                           |.|||  |:||.
Zfish  3848 KKKQRNKRTPKNGVDKPPSRWKKRKKDEDERQAIYTNTDTLMTQLKQQLSMLPLMEPLIGVNFAH 3912

  Fly   710 LSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYL---------LTPGERPPA 765
            .      .|.|||..||..:.......::.....|.:...:.|::.|         |.|...|.|
Zfish  3913 F------PPYGSGQLNGENRLSGSFGSASLDGVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPVA 3971

  Fly   766 EVAFANGKLNAEAWA--AAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSA 828
            .....||...||..|  |....:||....:..|.|.|..          .||         |.:.
Zfish  3972 RQKLLNGFATAEELARKAEVMVSKSLGQKQLTASFKAED----------DLL---------GHTI 4017

  Fly   829 SNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVF 893
            :..|             |.:|: |:||.:.....     ::.:...:..:...:| .|:.|....
Zfish  4018 TQGP-------------KTVDV-PASLPTPPHNN-----QEDLRGQEHCIDRDTP-DSFVPSSSP 4062

  Fly   894 EPSVELEI-QIP-LSKLNESVITKAEVESPLLSALDIK--EDTKKEVGQRVVETLLHKTGGNL-- 952
            |..|.:|| :.| ||::.|...:.|  .||::..||.|  |..:.||.............|.|
Zfish  4063 ESVVGMEISRYPDLSRVKEEPPSPA--VSPVIPILDCKGSEARRWEVKTEPPSNFFASQFGQLST 4125

  Fly   953 LLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAA 1017
            .|:.....::.|..|..     .::::...:|               |.::.......|..|..:
Zfish  4126 CLRTDLVPVSITLNPVA-----AMNIQGVVSA---------------LANMLCVSIPGNYEVTRS 4170

  Fly  1018 PNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALE----RLQRPQTP---------------- 1062
            |.|           |.|.:....:..|.|..:.:..:    ||.||..|
Zfish  4171 PGP-----------EHRSSIDMLSGLKVPHPTSLFHQQPGMRLHRPPLPHQTFSDGTAMVRRDYG 4224

  Fly  1063 -ARGRPRGRKPK-------------NREQAEAAPQ------------------------------ 1083
             ..|...|.||:             .|:..:..|.
Zfish  4225 QMHGSSLGSKPQWCSHCRVVVLGNGVRKSTKELPMNKLGHGGAVESLVFCSNNCLVLYSASMQSK 4289

  Fly  1084 ---------PPPKSEPEIRPAKKRGR----------------QPKQPVLEEPPPTPPPQQKKNKM 1123
                     ||.:|..:..|.|...:                ||||    .||||
Zfish  4290 LLDGKPNFPPPSESGDKQNPTKVLHQYNNNISDLDVHCLAQLQPKQ----SPPPT---------- 4340

  Fly  1124 EPNIRLPDGIDPNTNFSCK-------IRLKRRKNL--EAGTQP-----KKEKPV--QPVTVEEIP 1172
             |.|..|..........||       ::||.|...  ..|.:|     |:.|.:  :..:|:.|.
Zfish  4341 -PIISFPSITSEMLRGDCKPDTLKVTVKLKPRPRAVHNGGDEPRYLSGKRWKALRWRRWSVQIIV 4404

  Fly  1173 PE----IPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASC---------------- 1217
            |:    :|| :|||||     .|..:.|...|       .|.|:|...|
Zfish  4405 PKGNYHLPV-EEEIDA-----LLKKLGTSLRP-------EPMPKDMRRCCFCHEEGDGLTDGPAR 4456

  Fly  1218 ------------------SESSEDKAST------------------------------------- 1227
                              :|..|.:|..
Zfish  4457 LLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLSVRCAYCQQTGATSGCHRLRCTNAY 4521

  Fly  1228 ----------------TSLRKLSKVKKTYLVAG-------------LFSNHYKQ----------- 1252
                            |.|..|.:.:.|.|:.|             :|...|.|
Zfish  4522 HFTCALKAQCTFFKDKTMLCHLHRPRGTSLIGGGLLGTEHELRCFAVFRRVYVQRDESRQIASII 4586

  Fly  1253 --------------------SLMPPP----------------------------------AKVNK 1263
                                .|:|..                                  ..:|:
Zfish  4587 QRGEREHTFRVGSLVLHAVGQLLPQQMLAFHSMTAIFPVGYEASRIYWSMRHGNRRCHYVCSINE 4651

  Fly  1264 KPGLEEQV------GPASLL----PPPPYCEKYL-----RRTEMDFELPYDIWW----------- 1302
            ..|..|.|      |...|:    .|....:|.|     ||.|..|...:.::.
Zfish  4652 NDGSPEFVIRVVEQGYDDLILTGSSPKGVWDKVLEPVAERRNETGFLRLFPVYLKGEDLFGLTVS 4716

  Fly  1303 AYTN--SKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMV-- 1363
            |.|.  ..||.......:.:|..|..:....:..|.:|       |.....|:|..  :.|.|
Zfish  4717 AVTRIVESLPGVEACERYTFRYGRNPLMQLPLAINPSG-------CARSEPKACTH--IKRFVLR 4772

  Fly  1364 -YTECSPSNC-------------PAGEKCRNQKIQRHAVAPGVERFMTAD------------KGW 1402
             :|..|.|..             |..:...:.|..::       |.|.|:            :|.
Zfish  4773 PHTLTSTSKALQSPGNPAEIGVPPYSKHFVHSKSAQY-------RRMNAEWKSNVYLARSRIQGL 4830

  Fly  1403 GVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY-LNDTHHYCLHLDGGLVIDGQRMGSDCRFV 1466
            |:.....|.|.|.::||:|.:: ..|...|...:| ..:...|...:|...|||....|...|::
Zfish  4831 GLYAARDIEKYTMVIEYIGTII-RSEVANRKEKMYEAQNRGVYMFRIDSEHVIDATITGGPARYI 4894

  Fly  1467 NHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            ||||.|||..:..::....::::.:.|.|:.||||.|||.|.|.:.....||.|....||
Zfish  4895 NHSCAPNCITEVVALERGHKIIISSNRRIQRGEELCYDYKFDLEDDQHKIPCHCGAVNCR 4954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	80/546 (15%)
		AWS	1340..1388	CDD:197795	10/63 (16%)
		SET_ASH1L	1391..1531	CDD:380951	44/149 (30%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
kmt2ca	XP_005162602.2	None