Protein Alignment Shal and KCNK17

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_113648.2
• Gene: KCNK17 / 89822
• HGNCID: 14465
• Length: 332
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 52/220 - (23%)
• Similarity: 89/220 - (40%)
• Gaps: 58/220 - (26%)

  Fly   244 YLLRLFAAPD----RCKFVRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLR------VFRVF 298
            |..|..|||:    .|....:|:.::..:|    |:.||       :|.|.||.      ..|.|
Human     2 YRPRARAAPEGRVRGCAVPSTVLLLLAYLA----YLALG-------TGVFWTLEGRAAQDSSRSF 55

  Fly   299 RIFKFSRHSQGLRILGYTLKSCASE--LGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAF 361
            :..|:.      .:..:|   |...  |..|:..:..|....|:::    .|........:..:|
Human    56 QRDKWE------LLQNFT---CLDRPALDSLIRDVVQAYKNGASLL----SNTTSMGRWELVGSF 107

  Fly   362 WYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQR 426
            ::::.|:||:|||::.|.|:|.::.....:|.|:     |:.::|.|  |:.|..|:.....|.|
Human   108 FFSVSTITTIGYGNLSPNTMAARLFCIFFALVGI-----PLNLVVLN--RLGHLMQQGVNHWASR 165

  Fly   427 ---------KARLARIRIAKASSGA 442
                     |||..      |.|||
Human   166 LGGTWQDPDKARWL------AGSGA 184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:459842	41/182 (23%)
		DUF3399	471..535	CDD:463381
KCNK17	NP_113648.2	Ion_trans_2	81..157	CDD:462301	20/86 (23%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	116..121		3/4 (75%)
		Ion_trans_2	<206..268	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	221..226
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312