DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and KCNQ5

DIOPT Version :10

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_001153605.1 Gene:KCNQ5 / 56479 HGNCID:6299 Length:951 Species:Homo sapiens


Alignment Length:339 Identity:81/339 - (23%)
Similarity:143/339 - (42%) Gaps:65/339 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 LMDDKLSENGDQNLQQLTNMRQ---KMWRAFENP-------HTSTSALVFYYVTGFFIAVSVMAN 202
            |:...||....|:.::....|:   .::...|.|       |    |.||..|.|..|     .:
Human    89 LLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYH----AFVFLLVFGCLI-----LS 144

  Fly   203 VVETVPCGHRPGRAGTLPCGERYKIVFFC---LDTACVMIFTAEYLLRLFAA---------PDRC 255
            |..|:|              |..|:...|   |:...:::|..|:::|:::|         ..|.
Human   145 VFSTIP--------------EHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRL 195

  Fly   256 KFVRSVMSIIDVVAIMP--YYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLK 318
            :|.|....:||.:.::.  ..:......|...:.|..:||..::.|:.:..|.....::||..:.
Human   196 RFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVY 260

  Fly   319 SCASEL------GFLVFSLAMAIIIFATVMFY-AEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDM 376
            :.:.||      ||||       :||::.:.| .||:.| ..|::...|.|:..:|:||:||||.
Human   261 AHSKELITAWYIGFLV-------LIFSSFLVYLVEKDAN-KEFSTYADALWWGTITLTTIGYGDK 317

  Fly   377 VPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSG 441
            .|.|..|:::....:|.|:...|||..::.|.|: :..|.|...|...:|:...|.:......|.
Human   318 TPLTWLGRLLSAGFALLGISFFALPAGILGSGFA-LKVQEQHRQKHFEKRRNPAANLIQCVWRSY 381

  Fly   442 AAFVSKKKAAEARW 455
            ||  .:|..:.|.|
Human   382 AA--DEKSVSIATW 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727
Ion_trans 188..415 CDD:459842 59/247 (24%)
DUF3399 471..535 CDD:463381
KCNQ5NP_001153605.1 Ion_trans 126..358 CDD:459842 64/263 (24%)
Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937 370..378 1/7 (14%)
KCNQ_channel 466..653 CDD:460954
Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937 540..547
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..697
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 895..938
Blue background indicates that the domain is not in the aligned region.

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